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| Status |
Public on Sep 06, 2018 |
| Title |
Gene expression profiles from corpus callosum brain tissue obtained from cuprizone-treated mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Mouse cuprizone (CPZ ) model of experimental de- and remyelination was applied to mimic demyelination pathology of multiple sclerosis. The aim of the study was to profile whole genome expression to identify differentially expressed genes during the demyelinisation and after discontinuation of cuprizon treatment, during rapid remyelinisation in affected areas of mouse corpus callosum. Control mice were kept on a normal diet.
The following groups representing de- and remyelinisation pathology in corpus callosum of CPZ-treated mice were compared: Partial demyelination: 2weeks CPZ (dem_2w); Complete demyelination: 4weeks CPZ (dem_4w); Remyelination: 4weeks CPZ + UNTREATED (rem); and UNTREATED control (C). The experiments were performed using 3-4 animals per groups.
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| Overall design |
Nellie,A,Martin
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| Contributor(s) |
Nawrocki A, Molnar V, Elkjaer ML, Thygesen EK, Palkovits M, Acs P, Sejbaek T, Nielsen HH, Hegedus Z, Sellebjerg FT, Barbosa EV, Alcaraz N, Gallyas F, Svenningsen AF, Baumbach J, Lassmann H, Larsen MR, Illes Z |
| Citation(s) |
30114292 |
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| Submission date |
Jun 29, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Viktor Molnár |
| E-mail(s) |
[email protected]
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| Organization name |
Semmelweis University
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| Department |
Department of Genetics, Cell- and Immunobiology
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| Street address |
Nagyvárad tér 4.
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| City |
Budapest |
| ZIP/Postal code |
1089 |
| Country |
Hungary |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA392449 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE100663_RAW.tar |
34.6 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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