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    Nin Ninein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ninprovided by FlyBase
    Official Full Name
    Nineinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000228
    Locus tag
    Dmel_CG14025
    See related
    AllianceGenome:FB:FBgn0000228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    brg25D; bsg25D; Bsg25D; bsq25D; CG14025; Dmel\CG14025; nin
    Summary
    Enables microtubule binding activity. Involved in microtubule organizing center attachment site organization. Located in pericentriolar material. Is expressed in several structures, including anlage in statu nascendi; antennal primordium; germline cell; head epidermis primordium; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein) and NINL (ninein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nin in Genome Data Viewer
    Location:
    25D2-25D3; 2-16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5271728..5278548, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5271728..5278548, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene Cytochrome P450 4ac2 Neighboring gene Cytochrome P450 4ac3 Neighboring gene long non-coding RNA:CR44743 Neighboring gene long non-coding RNA:CR44742 Neighboring gene Bub1 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of bsg25D: a blastoderm-specific locus of Drosophila melanogaster. Boyer PD, et al. Nucleic Acids Res, 1987 Mar 11. PMID 3104878, Free PMC Article
    2. Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development. Kowanda M, et al. Biol Open, 2016 Aug 15. PMID 27422905, Free PMC Article
    3. The Drosophila Ninein homologue Bsg25D cooperates with Ensconsin in myonuclear positioning. Rosen JN, et al. J Cell Biol, 2019 Feb 4. PMID 30626718, Free PMC Article
    4. EGF homologous sequences encoded in the genome of Drosophila melanogaster, and their relation to neurogenic genes. Knust E, et al. EMBO J, 1987 Mar. PMID 3107986, Free PMC Article
    5. A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport. Safieddine A, et al. Nat Commun, 2021 Mar 1. PMID 33649340, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule organizing center attachment site organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ninein
    Names
    Blastoderm-specific gene 25D
    CG14025-PB
    CG14025-PC
    CG14025-PD
    CG14025-PE
    CG14025-PF
    CG14025-PG
    CG14025-PH
    Nin-PB
    Nin-PC
    Nin-PD
    Nin-PE
    Nin-PF
    Nin-PG
    Nin-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5271728..5278548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273163.2 → NP_001260092.1  ninein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHA5, M9PB42
      Conserved Domains (4) summary
      COG1196
      Location:393 → 742
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:644 → 926
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:271 → 510
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13851
      Location:904 → 1006
      GAS; Growth-arrest specific micro-tubule binding

    2. NM_001201770.2 → NP_001188699.1  ninein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHA5, M9MRD3
      Conserved Domains (4) summary
      COG1196
      Location:401 → 750
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:652 → 934
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      TIGR02168
      Location:279 → 518
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13851
      Location:912 → 1014
      GAS; Growth-arrest specific micro-tubule binding

    3. NM_164637.3 → NP_723072.1  ninein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C9QPC2, P11929, Q8IPK7, Q9VMS6
      UniProtKB/TrEMBL
      E8NHA5
      Related
      FBpp0078718
      Conserved Domains (4) summary
      COG1196
      Location:401 → 750
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:279 → 518
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13851
      Location:924 → 1026
      GAS; Growth-arrest specific micro-tubule binding
      pfam15402
      Location:742 → 910
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    4. NM_001273164.2 → NP_001260093.1  ninein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHA5, M9PC27
      Conserved Domains (4) summary
      COG1196
      Location:428 → 777
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:306 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13851
      Location:951 → 1053
      GAS; Growth-arrest specific micro-tubule binding
      pfam15402
      Location:769 → 937
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    5. NM_164638.3 → NP_723073.1  ninein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NHA5, Q8IPK8
      Related
      FBpp0078719
      Conserved Domains (4) summary
      COG1196
      Location:342 → 691
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:220 → 459
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13851
      Location:865 → 967
      GAS; Growth-arrest specific micro-tubule binding
      pfam15402
      Location:683 → 851
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    6. NM_057568.6 → NP_476916.4  ninein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476916.4

      Status: REVIEWED

      Conserved Domains (2) summary
      COG1196
      Location:393 → 742
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:271 → 510
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. NM_001201769.2 → NP_001188698.1  ninein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188698.1

      Status: REVIEWED

      Conserved Domains (2) summary
      COG1196
      Location:342 → 691
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:220 → 459
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C9QPC2 C9QPC2
    M9MRD3 M9MRD3
    M9PB42 M9PB42
    M9PC27 M9PC27
    P11929.3 P11929
    Q8IPK8 Q8IPK8
    Q9VMS6 Q9VMS6

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