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    CoRest CoRest [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32941, updated on 9-Dec-2024

    Summary

    Official Symbol
    CoRestprovided by FlyBase
    Official Full Name
    CoRestprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261573
    Locus tag
    Dmel_CG42687
    See related
    AllianceGenome:FB:FBgn0261573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH01486; BcDNA:LD11215; CG32534; CG32535; CG33525; CG3878; CG42687; CoREST; CoRESTG; dCoREST; Dmel\CG42687; i169
    Old locus tag
    Dmel_CG32534; Dmel_CG33525
    Summary
    Enables chromatin binding activity and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA methylation-dependent heterochromatin formation. Located in nucleus. Part of transcription repressor complex. Is expressed in female germline cell; follicle cell; organism; and spermatozoon. Orthologous to human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CoRest in Genome Data Viewer
    Location:
    18C8-18C8; 1-62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19521929..19530896)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19415962..19424929)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene 6-phosphofructo-2-kinase Neighboring gene Isocitrate dehydrogenase 3a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding PubMed 
    enables protein binding PubMed 
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex  
    located_in nucleus PubMed 
    part_of transcription regulator complex  
    part_of transcription repressor complex PubMed 

    General protein information

    Preferred Names
    CoRest
    Names
    CG42687-PA
    CG42687-PC
    CG42687-PD
    CG42687-PE
    CG42687-PF
    CG42687-PG
    CG42687-PH
    CG42687-PI
    CG42687-PJ
    CG42687-PK
    CoRest-PA
    CoRest-PC
    CoRest-PD
    CoRest-PE
    CoRest-PF
    CoRest-PG
    CoRest-PH
    CoRest-PI
    CoRest-PJ
    CoRest-PK

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19521929..19530896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014754.1NP_001014754.1  CoRest, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5
      Conserved Domains (3) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. NM_001258824.1NP_001245753.1  CoRest, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAG1
      Conserved Domains (4) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:540582
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. NM_001201742.3NP_001188671.1  CoRest, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAG1
      Conserved Domains (4) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:540582
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    4. NM_001014752.4NP_001014752.2  CoRest, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014752.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4S3, Q494F9, Q59E35, Q59E36, Q8MSX7, Q95TC9, Q9VWH3
      Conserved Domains (4) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:306348
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    5. NM_001014753.3NP_001014753.1  CoRest, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q59E36
      Conserved Domains (4) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:304346
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    6. NM_001258825.2NP_001245754.1  CoRest, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAG1
      Conserved Domains (4) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:540582
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    7. NM_001014755.2NP_001014755.1  CoRest, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5
      Conserved Domains (3) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    8. NM_001014756.2NP_001014756.1  CoRest, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5
      Conserved Domains (3) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    9. NM_001272777.1NP_001259706.1  CoRest, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5, M9PJR2
      Conserved Domains (3) summary
      smart00717
      Location:179225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92144
      ELM2; ELM2 domain
      cl21498
      Location:180224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    10. NM_001258826.1NP_001245755.1  CoRest, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHV0, M9NHB6
      Conserved Domains (2) summary
      smart00717
      Location:5297
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:5294
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
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