stumps stumps [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: stumpsprovided by FlyBase
Official Full Name: stumpsprovided by FlyBase
Primary source: FLYBASE:FBgn0020299
Locus tag: Dmel_CG31317
See related: AllianceGenome:FB:FBgn0020299
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0837/10; anon-EST:CL47; anon-estC; C; CG18485; CG31317; CG3375; Dmel\CG31317; dof; Dof; DOF; dof/hbr; dof/hbr/sms; Dof/stumps/heartbroken; dof1; gene C; hbr; Hbr; Hbr/Dof; heartbroken/dof; i21; i28; l(3)09904; l(3)S083710; P1740; sms; Stumps; stumps/dof
Summary: Enables fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including mesodermal cell fate commitment; mesodermal cell migration; and open tracheal system development. Located in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; larval muscle cell; tracheal primordium; and trunk visceral muscle primordium. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and systemic scleroderma (multiple). Orthologous to several human genes including PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 88C6-88C9; 3-55 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14577217..14608079)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10402939..10433801)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results identify a novel phosphotyrosine motif present in four copies in Dof and show that these motifs are phosphorylated and contribute to FGF signal transduction.
Title: A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission.
We have identified 44 proteins that interact with Dof in a yeast two-hybrid screen.
Title: Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP.
We suggest that the developmental patterns of Heartbroken/Dof and Sprouty result in defining the domain and timing of activation of the Fibroblast growth factor receptor Heartless in specific myoblasts, thereby converting them into founder cells.
Title: Drosophila Heartless acts with Heartbroken/Dof in muscle founder differentiation.
Data show that Downstream-of-FGFR is a substrate for fibroblast growth factor receptors (FGFRs) and recruits Corkscrew, leading to FGF-induced cell migration and activation of the Ras/MAPK pathway.
Title: Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation.
identified a region within the N terminus of the protein that is required for FGF-dependent signal transduction and is necessary for efficient interaction of Dof with the FGF receptor Heartless
Title: A functional domain of Dof that is required for fibroblast growth factor signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell fate determination, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	TAS Traceable Author Statement more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: stumps

Names: CG31317-PB; CG31317-PC; CG31317-PD; CG31317-PE; CG31317-PF; Downstream-of-FGFR; downstream of FGF; downstream of FGF receptor; downstream of FGFR; downstream of FGFR/Heartbroken/Stumps; downstream-of-FGF receptor; heartbroken; stumps-PB; stumps-PC; stumps-PD; stumps-PE; stumps-PF