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    SRT2 sirtuin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830782, updated on 18-Sep-2024

    Summary

    Official Symbol
    SRT2
    Official Full Name
    sirtuin 2
    Primary source
    TAIR:AT5G09230
    Locus tag
    AT5G09230
    See related
    Araport:AT5G09230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSRT2; sirtuin 2; SIRTUIN 2; T2K12.8
    Summary
    Encodes SRT2, a member of the SIR2 (sirtuin) family HDAC (histone deacetylase) (SRT1/AT5g55760, SRT2/AT5G09230).
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    Genomic context

    See SRT2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (2871365..2873789)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene amino acid permease 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ssDNA-binding transcriptional regulator Neighboring gene ssDNA-binding transcriptional regulator Neighboring gene vacuolar protein sorting-associated protein 20.2

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_003076.8

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    NM_001085081.2
    NM_120959.4
    NM_180464.4
    NM_180465.3
    NM_180466.4
    NM_203024.3
    NM_203025.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ binding  
    enables deacetylase activity PubMed 
    enables histone H3K9 acetyltransferase activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in mitochondrial matrix PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    sirtuin 2
    NP_001078550.1
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 6471 Blast hits to 6454 proteins in 2013 species: Archae - 152; Bacteria - 3779; Metazoa - 822; Fungi - 681; Plants - 106; Viruses - 0; Other Eukaryotes - 931 (source: NCBI BLink).
    NP_568207.1
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_850795.1
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 6440 Blast hits to 6423 proteins in 1998 species: Archae - 152; Bacteria - 3742; Metazoa - 823; Fungi - 702; Plants - 106; Viruses - 0; Other Eukaryotes - 915 (source: NCBI BLink).
    NP_850796.2
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_850797.1
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 5572 Blast hits to 5555 proteins in 1862 species: Archae - 152; Bacteria - 3346; Metazoa - 798; Fungi - 483; Plants - 103; Viruses - 0; Other Eukaryotes - 690 (source: NCBI BLink).
    NP_974753.1
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974754.1
    • sirtuin 2 (SRT2); FUNCTIONS IN: NAD binding, DNA binding, zinc ion binding, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; INVOLVED IN: chromatin silencing, defense response to bacterium, negative regulation of defense response, regulation of transcription, DNA-dependent; LOCATED IN: chromatin silencing complex, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent histone deacetylase, silent information regulator Sir2 (InterPro:IPR003000); BEST Arabidopsis thaliana protein match is: sirtuin 1 (TAIR:AT5G55760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2871365..2873789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180464.4 → NP_850795.1  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850795.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFU7, F4KCI0, Q94AQ6, Q9FY91
      UniProtKB/TrEMBL
      A0A5S9Y374, A0A654FZI4
      Conserved Domains (1) summary
      cd01409
      Location:85 → 359
      SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
    2. NM_203025.3 → NP_974754.1  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KCI5
      Conserved Domains (1) summary
      cl00195
      Location:28 → 257
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. NM_203024.3 → NP_974753.1  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCZ7, A0A5S9Y374, A0A654FZI4
      Conserved Domains (1) summary
      cd01409
      Location:66 → 340
      SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
    4. NM_120959.4 → NP_568207.1  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568207.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFU7, F4KCI0, Q94AQ6, Q9FY91
      UniProtKB/TrEMBL
      A0A5S9Y374, A0A654FZI4
      Conserved Domains (1) summary
      cd01409
      Location:85 → 359
      SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
    5. NM_180465.3 → NP_850796.2  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850796.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UCJ1, F4KCI3
      Conserved Domains (1) summary
      cl00195
      Location:85 → 324
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    6. NM_180466.4 → NP_850797.1  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KCI5
      Conserved Domains (1) summary
      cl00195
      Location:28 → 257
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    7. NM_001085081.2 → NP_001078550.1  sirtuin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y374, A0A654FZI4
      Conserved Domains (1) summary
      cd01409
      Location:88 → 362
      SIRT4; SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
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