BIP1 heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BIP1
Official Full Name: heat shock protein 70 (Hsp 70) family protein
Primary source: TAIR:AT5G28540
Locus tag: AT5G28540
See related: Araport:AT5G28540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T26D3.10; T26D3_10
Summary: Encodes the luminal binding protein BiP, an ER-localized member of the HSP70 family. BiP is composed of an N-terminal ATP binding domain and a C-terminal domain that binds to hydrophobic patches on improperly/incompletely folded proteins in an ATP-dependent manner. Involved in polar nuclei fusion during proliferation of endosperm nuclei.
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Genomic context

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See BIP1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (10540123..10543558, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis HOP3, whose function was not studied before, interacts in vivo with cytosolic HSP90 and HSP70, and, unexpectedly, with binding immunoglobulin protein (BiP), a HSP70 endoplasmic reticulum-resident protein.
Title: HOP3, a member of the HOP family in Arabidopsis, interacts with BiP and plays a major role in the ER stress response.
BIP3 supports the early stages of female gametophyte development, but not polar nuclear fusion, in the absence of BiP1 and BiP2.
Title: BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana.
the DnaJ domain of TMS1 could interact with BiP1 and BiP3, and could stimulate their ATPase enzyme activities.
Title: The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis.
the bip1 bip2 bip3 triple mutation is lethal in pollen.
Title: Multiple BiP genes of Arabidopsis thaliana are required for male gametogenesis and pollen competitiveness.
Data show detectable amounts of YFP-bZIP28 escaped from endoplasmic reticulum (ER) to nuclei under unstressed conditions in the bip1/bip1 bip2/+ and in the bip1/+ bip2/bip2 and bip3 mutant lines.
Title: BINDING PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis.
bip1 bip2 double mutation causes defects in the fusion of polar nuclei during female gametophyte development.
Title: BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_122737.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within polar nucleus fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein folding	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info	PubMed
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in secretory vesicle	HDA more info	PubMed

General protein information

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Preferred Names: heat shock protein 70 (Hsp 70) family protein

NP_198206.1

BIP1; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, ER-associated protein catabolic process, response to heat, polar nucleus fusion; LOCATED IN: cell wall, plasma membrane, chloroplast, vacuole, endoplasmic reticulum lumen; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: Heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G42020.1); Has 36391 Blast hits to 35786 proteins in 4820 species: Archae - 162; Bacteria - 17493; Metazoa - 3988; Fungi - 1814; Plants - 1283; Viruses - 341; Other Eukaryotes - 11310 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

10540123..10543558 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122737.4 → NP_198206.1 heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_198206.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q41928, Q56Y82, Q9LKR3

UniProtKB/TrEMBL

A0A5S9Y8G8, A0A654G567, A0A7G2FAT4

Conserved Domains (1) summary

PTZ00009
Location:35 → 644

PTZ00009; heat shock 70 kDa protein; Provisional