BIP2 Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BIP2
Official Full Name: Heat shock protein 70 (Hsp 70) family protein
Primary source: TAIR:AT5G42020
Locus tag: AT5G42020
See related: Araport:AT5G42020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BIP; luminal binding protein; MJC20.12; MJC20_12
Summary: Luminal binding protein (BiP2) involved in polar nuclei fusion during proliferation of endosperm nuclei.
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Genomic context

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See BIP2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (16807342..16810693, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BIP3 supports the early stages of female gametophyte development, but not polar nuclear fusion, in the absence of BiP1 and BiP2.
Title: BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana.
the bip1 bip2 bip3 triple mutation is lethal in pollen.
Title: Multiple BiP genes of Arabidopsis thaliana are required for male gametogenesis and pollen competitiveness.
Data show detectable amounts of YFP-bZIP28 escaped from endoplasmic reticulum (ER) to nuclei under unstressed conditions in the bip1/bip1 bip2/+ and in the bip1/+ bip2/bip2 and bip3 mutant lines.
Title: BINDING PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis.
The endoplasmic reticulum-resident chaperone BiP accumulates differentially depending on the level of activation of the bZIP60/IRE1 pathway.
Title: Alteration of the bZIP60/IRE1 pathway affects plant response to ER stress in Arabidopsis thaliana.
bip1 bip2 double mutation causes defects in the fusion of polar nuclei during female gametophyte development.
Title: BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana.
BiP is induced by sugar independent of the cis-element responsible for the unfolded protein response
Title: Induction of BiP by sugar independent of a cis-element for the unfolded protein response in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001344430.1

Supported by ESTs:

NM_123567.3

Supported by ESTs:

NM_180788.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within polar nucleus fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein folding	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	TAS Traceable Author Statement more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info	PubMed
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in secretory vesicle	HDA more info	PubMed

General protein information

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Preferred Names: Heat shock protein 70 (Hsp 70) family protein

NP_199017.2

luminal binding protein (BIP); FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to cadmium ion, response to heat, polar nucleus fusion, response to endoplasmic reticulum stress; LOCATED IN: in 8 components; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G28540.1); Has 34912 Blast hits to 34423 proteins in 4667 species: Archae - 159; Bacteria - 17150; Metazoa - 3676; Fungi - 1797; Plants - 1301; Viruses - 340; Other Eukaryotes - 10489 (source: NCBI BLink).

NP_851119.1

BIP2; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to cadmium ion, response to heat, polar nucleus fusion, response to endoplasmic reticulum stress; LOCATED IN: in 8 components; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G28540.1); Has 36681 Blast hits to 36078 proteins in 4871 species: Archae - 169; Bacteria - 17752; Metazoa - 3980; Fungi - 1822; Plants - 1284; Viruses - 342; Other Eukaryotes - 11332 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16807342..16810693 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180788.3 → NP_851119.1 Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851119.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39042, Q39043

UniProtKB/TrEMBL

A0A178UG43, A0A5S9YAG6, A0A7G2FAT4

Conserved Domains (1) summary

PTZ00009
Location:35 → 654

PTZ00009; heat shock 70 kDa protein; Provisional
NM_001344430.1 → NP_001331824.1 Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BF32, A0A7G2FAT4
NM_123567.3 → NP_199017.2 Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199017.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FAT4, F4K007

Conserved Domains (2) summary

cd10241
Location:35 → 409

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:35 → 599

PTZ00009; heat shock 70 kDa protein; Provisional