LpR1 Lipophorin receptor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LpR1provided by FlyBase
Official Full Name: Lipophorin receptor 1provided by FlyBase
Primary source: FLYBASE:FBgn0066101
Locus tag: Dmel_CG31094
See related: AllianceGenome:FB:FBgn0066101
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31094; CG31095; CG4861; CG4870; CG4874; CT15569; Dmel\CG31094; lpr1
Summary: Enables lipoprotein particle receptor activity. Involved in several processes, including lipid homeostasis; mushroom body development; and transport across blood-brain barrier. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval oenocyte; ganglia; larval nervous system; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 96F1-96F2; 3-89 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25741348..25763105, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21567070..21588827, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging.
Title: Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging.
activity-induced isoform-specific upregulation of Drosophila lipophorin receptors LpR1 and LpR2, are reported.
Title: Transcriptional Regulation of Lipophorin Receptors Supports Neuronal Adaptation to Chronic Elevations of Activity.
lipophorin receptor 1 and 2 (lpr1 and lpr2) are essential for the efficient uptake and accumulation of neutral lipids by oocytes and cells of the imaginal discs
Title: Drosophila lipophorin receptors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism.
Serpin is taken up in the garland and pericardial cells by LpR1, probably as a serpin/proteinase complex.
Title: Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipoprotein particle receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport across blood-brain barrier	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: lipophorin receptor 1

Names: CG31094-PD; CG31094-PG; CG31094-PH; CG31094-PJ; CG31094-PK; CG31094-PL; CG31094-PP; CG31094-PQ; CG31094-PR; CG31094-PS; LpR1-PD; LpR1-PG; LpR1-PH; LpR1-PJ; LpR1-PK; LpR1-PL; LpR1-PP; LpR1-PQ; LpR1-PR; LpR1-PS

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25741348..25763105 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276044.1 → NP_001262973.1 lipophorin receptor 1, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262973.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI25

Conserved Domains (6) summary

smart00192
Location:178 → 210

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:663 → 706

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:510 → 540

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:219 → 254

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:382 → 418

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:473 → 508

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001276045.1 → NP_001262974.1 lipophorin receptor 1, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262974.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHW9, Q8IGR9

Conserved Domains (6) summary

smart00192
Location:70 → 102

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:555 → 598

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:402 → 432

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:111 → 146

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:274 → 310

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:365 → 400

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_206573.2 → NP_996296.2 lipophorin receptor 1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996296.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NP66, Q9VBN0

Conserved Domains (6) summary

smart00192
Location:178 → 210

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:665 → 708

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:512 → 542

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:304 → 334

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:384 → 420

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:475 → 510

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001276043.1 → NP_001262972.1 lipophorin receptor 1, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262972.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KI25

Conserved Domains (6) summary

smart00192
Location:178 → 210

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:663 → 706

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:510 → 540

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:219 → 254

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:382 → 418

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:473 → 508

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001104464.2 → NP_001097934.2 lipophorin receptor 1, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097934.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JRD0

Conserved Domains (6) summary

smart00192
Location:178 → 210

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:704 → 747

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:551 → 581

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:219 → 254

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:423 → 459

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:514 → 549

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001104462.1 → NP_001097932.1 lipophorin receptor 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097932.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JRD1, Q8IGR9

Conserved Domains (6) summary

smart00192
Location:30 → 62

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:517 → 560

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:364 → 394

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:156 → 186

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:236 → 272

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:327 → 362

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_170240.3 → NP_733119.2 lipophorin receptor 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733119.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGR9, Q9VBN1

Conserved Domains (6) summary

smart00192
Location:30 → 62

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:517 → 560

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:364 → 394

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:156 → 186

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:236 → 272

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:327 → 362

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001104461.3 → NP_001097931.3 lipophorin receptor 1, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097931.3

Status: REVIEWED

UniProtKB/TrEMBL

A8JRD2, Q8IGR9

Conserved Domains (6) summary

smart00192
Location:30 → 62

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:515 → 558

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:362 → 392

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:71 → 106

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:234 → 270

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:325 → 360

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001104463.3 → NP_001097933.2 lipophorin receptor 1, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097933.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JRC9, Q6NP71

Conserved Domains (6) summary

smart00192
Location:178 → 210

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:624 → 667

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:471 → 501

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:263 → 293

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:343 → 379

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:434 → 469

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001170263.2 → NP_001163734.1 lipophorin receptor 1, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163734.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIX9

Conserved Domains (6) summary

smart00192
Location:178 → 210

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:665 → 708

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:512 → 542

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:304 → 334

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:384 → 420

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:475 → 510

FXa_inhibition; Coagulation Factor Xa inhibitory site

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KHW9		A0A0B4KHW9
A0A0B4KI25		A0A0B4KI25
A8JRD0		A8JRD0
A8JRD1		A8JRD1
A8JRD2		A8JRD2
E1JIX9		E1JIX9
Q6NP71		Q6NP71
Q8IGR9		Q8IGR9
Q9VBN0		Q9VBN0
Q9VBN1		Q9VBN1