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Conserved domains on  [gi|281362594|ref|NP_001097933|]
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lipophorin receptor 1, isoform J [Drosophila melanogaster]

Protein Classification

LDL receptor domain-containing protein( domain architecture ID 11257860)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; similar to Bos taurus CD320 antigen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 624-667 2.07e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 2.07e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281362594   624 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 667
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 178-210 7.76e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 7.76e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 669-710 1.23e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.23e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362594   669 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 710
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
343-379 9.15e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 9.15e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 281362594  343 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 379
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 135-167 8.87e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 8.87e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 263-293 1.41e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.41e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 281362594 263 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 293
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 434-469 6.72e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 6.72e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281362594  434 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 469
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 396-424 3.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 3.34e-07
                           10        20
                   ....*....|....*....|....*....
gi 281362594   396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 303-335 3.90e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 3.90e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   303 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 335
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 582-622 5.55e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 5.55e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 281362594   582 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 622
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-501 1.38e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.38e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   471 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 501
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 784-825 2.16e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 281362594  784 CQSVNGHCSHLCLPAPRinerspRISCACPTGLKLMVDGLMC 825
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 689-735 5.51e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281362594  689 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 735
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 624-667 2.07e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 2.07e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281362594   624 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 667
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 178-210 7.76e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 7.76e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 669-710 1.23e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.23e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362594   669 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 710
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 179-212 2.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 2.03e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 281362594 179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 646-684 2.95e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 2.95e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 281362594  646 MYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLD 684
Cdd:pfam00058   3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
178-212 4.44e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 4.44e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 281362594  178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
343-379 9.15e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 9.15e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 281362594  343 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 379
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 345-379 1.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 1.06e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 281362594 345 CRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 379
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 135-167 8.87e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 8.87e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 344-376 1.38e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.38e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   344 TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDE 376
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 136-168 1.39e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.39e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 281362594 136 CDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 263-293 1.41e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.41e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 281362594 263 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 293
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 434-469 6.72e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 6.72e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281362594  434 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 469
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
135-168 6.77e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 6.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 281362594  135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
262-293 8.23e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 8.23e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362594  262 AEHTCTNGACIAKRWVCDGDPDCSDGSDERSC 293
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 263-290 1.67e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.67e-08
                           10        20
                   ....*....|....*....|....*...
gi 281362594   263 EHTCTNGACIAKRWVCDGDPDCSDGSDE 290
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 396-424 3.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 3.34e-07
                           10        20
                   ....*....|....*....|....*....
gi 281362594   396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 303-335 3.90e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 3.90e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   303 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 335
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 396-424 4.09e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 4.09e-07
                         10        20
                 ....*....|....*....|....*....
gi 281362594 396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 303-340 5.07e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 5.07e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 281362594 303 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 340
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE--ENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
301-340 3.09e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 3.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 281362594  301 TPCLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 340
Cdd:pfam00057   1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDE--ENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 582-622 5.55e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 5.55e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 281362594   582 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 622
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-501 1.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.38e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   471 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 501
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 784-825 2.16e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 281362594  784 CQSVNGHCSHLCLPAPRinerspRISCACPTGLKLMVDGLMC 825
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-501 5.47e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 5.47e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 281362594 471 DINECEVPGKCS--QICVNEIGGFKCECEAGYM 501
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
396-424 6.41e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 6.41e-05
                          10        20
                  ....*....|....*....|....*....
gi 281362594  396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA pfam07645
Calcium-binding EGF domain;
471-499 6.24e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.24e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362594  471 DINECEVPGK-CSQ--ICVNEIGGFKCECEAG 499
Cdd:pfam07645   1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 689-735 5.51e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281362594  689 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 735
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-470 7.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362594   431 INECASKNGgCMH--QCIDLKVGHHCECHEGYKlspDKRNCQ 470
Cdd:smart00179   2 IDECASGNP-CQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 624-667 2.07e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 2.07e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 281362594   624 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 667
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 178-210 7.76e-12

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.34  E-value: 7.76e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 669-710 1.23e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.23e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362594   669 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 710
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 179-212 2.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 2.03e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 281362594 179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 646-684 2.95e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 2.95e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 281362594  646 MYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLD 684
Cdd:pfam00058   3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
178-212 4.44e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 4.44e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 281362594  178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
343-379 9.15e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 9.15e-11
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 281362594  343 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 379
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 345-379 1.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.22  E-value: 1.06e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 281362594 345 CRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 379
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 135-167 8.87e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 8.87e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 344-376 1.38e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.38e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   344 TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDE 376
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 136-168 1.39e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.39e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 281362594 136 CDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 263-293 1.41e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 1.41e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 281362594 263 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 293
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 434-469 6.72e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.24  E-value: 6.72e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 281362594  434 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 469
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
135-168 6.77e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 6.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 281362594  135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
262-293 8.23e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.87  E-value: 8.23e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362594  262 AEHTCTNGACIAKRWVCDGDPDCSDGSDERSC 293
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 263-290 1.67e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.09  E-value: 1.67e-08
                           10        20
                   ....*....|....*....|....*...
gi 281362594   263 EHTCTNGACIAKRWVCDGDPDCSDGSDE 290
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 396-424 3.34e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 3.34e-07
                           10        20
                   ....*....|....*....|....*....
gi 281362594   396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 303-335 3.90e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 3.90e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   303 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 335
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 396-424 4.09e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 4.09e-07
                         10        20
                 ....*....|....*....|....*....
gi 281362594 396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 303-340 5.07e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.82  E-value: 5.07e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 281362594 303 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 340
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE--ENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
301-340 3.09e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 3.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 281362594  301 TPCLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 340
Cdd:pfam00057   1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDE--ENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 582-622 5.55e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 5.55e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 281362594   582 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 622
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-501 1.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.38e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 281362594   471 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 501
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 784-825 2.16e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.23  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 281362594  784 CQSVNGHCSHLCLPAPRinerspRISCACPTGLKLMVDGLMC 825
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 453-474 3.79e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 41.24  E-value: 3.79e-05
                          10        20
                  ....*....|....*....|..
gi 281362594  453 HCECHEGYKLSPDKRNCQDINE 474
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-501 5.47e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 5.47e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 281362594 471 DINECEVPGKCS--QICVNEIGGFKCECEAGYM 501
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
396-424 6.41e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 6.41e-05
                          10        20
                  ....*....|....*....|....*....
gi 281362594  396 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 424
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA pfam07645
Calcium-binding EGF domain;
471-499 6.24e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 6.24e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 281362594  471 DINECEVPGK-CSQ--ICVNEIGGFKCECEAG 499
Cdd:pfam07645   1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 137-219 3.57e-03

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 39.39  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362594  137 DEK-QFQCHSGDCIPIRF--VCDGDADCKDHSDEQIKeckfieATCSSDQFRCGNGNCIP--------NKWRCDQESdCA 205
Cdd:pfam12999  33 DENgNWKCLNHSEIKLSFdqVNDDYCDCPDGSDEPGT------NACSNGKFYCANEGFIPgyipsfkvDDGVCDYDI-CC 105

                          90
                  ....*....|....
gi 281362594  206 DGSDEANELCNQTC 219
Cdd:pfam12999 106 DGSDEALGKCPNKC 119
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 689-735 5.51e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 281362594  689 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 735
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-470 7.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 281362594   431 INECASKNGgCMH--QCIDLKVGHHCECHEGYKlspDKRNCQ 470
Cdd:smart00179   2 IDECASGNP-CQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 475-508 8.62e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 34.91  E-value: 8.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 281362594  475 CEV-PGKCSQICVNEIGGFKCECEAGYMRDPKNHT 508
Cdd:pfam14670   1 CSVnNGGCSHLCLNTPGGYTCSCPEGYELQDDGRT 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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