Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 281362596    704 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 747
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 281362596  343 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 373
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 281362596   514 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 549
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    383 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 415
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    551 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 581
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 281362596   769 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 815
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 281362596    704 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 747
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....
gi 281362596  179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 281362596   423 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 459
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 281362596  343 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 373
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    424 TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDE 456
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 281362596   219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:pfam00057    3 CSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 281362596   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20
                    ....*....|....*....|....*...
gi 281362596    343 EHTCTNGACIAKRWVCDGDPDCSDGSDE 370
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDE 251
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20
                    ....*....|....*....|....*....
gi 281362596    476 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    383 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 415
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 281362596    662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 702
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    551 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 581
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 281362596  551 DINECEVPGKCS--QICVNEIGGFKCECEAGYM 581
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 281362596   551 DINECEVPGK-CSQ--ICVNEIGGFKCECEAG 579
Cdd:pfam07645    1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 281362596    704 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 747
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....
gi 281362596  179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 281362596   423 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 459
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 281362596  343 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 373
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    424 TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDE 456
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 281362596   219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:pfam00057    3 CSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 281362596   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20
                    ....*....|....*....|....*...
gi 281362596    343 EHTCTNGACIAKRWVCDGDPDCSDGSDE 370
Cdd:smart00192    6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDE 251
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20
                    ....*....|....*....|....*....
gi 281362596    476 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504
Cdd:smart00192    5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    383 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 415
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 281362596    662 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 702
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 281362596    551 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 581
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                           10        20
                   ....*....|....*....|..
gi 281362596   533 HCECHEGYKLSPDKRNCQDINE 554
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22

Low-density lipoprotein receptor domain class A;

                           10        20
                   ....*....|....*....|....*....
gi 281362596   476 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281362596   137 DEK-QFQCHSGDCIPIRF--VCDGDADCKDHSDEQIKeckfieATCSSDQFRCGNGNCIP--------NKWRCDQESdCA 205
Cdd:pfam12999   33 DENgNWKCLNHSEIKLSFdqVNDDYCDCPDGSDEPGT------NACSNGKFYCANEGFIPgyipsfkvDDGVCDYDI-CC 105

                           90
                   ....*....|....
gi 281362596   206 DGSDEANELCMNAC 219
Cdd:pfam12999  106 DGSDEALGKCPNKC 119