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    gly-3 Polypeptide N-acetylgalactosaminyltransferase 3 [ Caenorhabditis elegans ]

    Gene ID: 176112, updated on 27-Dec-2024

    Summary

    Official Symbol
    gly-3
    Official Full Name
    Polypeptide N-acetylgalactosaminyltransferase 3
    Primary source
    WormBase:WBGene00001628
    Locus tag
    CELE_ZK688.8
    See related
    AllianceGenome:WB:WBGene00001628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in hypodermis; intestine; rectal gland cell; and reproductive system. Orthologous to several human genes including GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See gly-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (7914306..7917767, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Putative protein tag-250 Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in membrane  

    General protein information

    Preferred Names
    Polypeptide N-acetylgalactosaminyltransferase 3
    NP_498722.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7914306..7917767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066321.7 → NP_498722.1  Polypeptide N-acetylgalactosaminyltransferase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34678, Q9U003
      Conserved Domains (4) summary
      cd02510
      Location:173 → 473
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:486 → 604
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:486 → 604
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam10111
      Location:173 → 438
      Glyco_tranf_2_2; Glycosyltransferase like family 2
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