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elpc-4 Elongator complex protein 4 [ Caenorhabditis elegans ]

Gene ID: 182929, updated on 9-Dec-2024

Summary

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Official Symbol
elpc-4
Official Full Name
Elongator complex protein 4
Primary source
WormBase:WBGene00016128
Locus tag
CELE_C26B2.6
See related
AllianceGenome:WB:WBGene00016128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphorylase kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Predicted to be located in nucleus. Predicted to be part of elongator holoenzyme complex and transcription elongation factor complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See elpc-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (8016994..8018221)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C3H1-type domain-containing protein Neighboring gene Cytochrome c oxidase assembly protein COX14;Cytochrome c oxidase assembly protein COX20, mitochondrial Neighboring gene Dynactin subunit 4 Neighboring gene Membrane-associated kinase regulator Neighboring gene Nuclear hormone receptor family member nhr-31 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Kim S, et al. Genetics, 2010 Aug. PMID 20479142, Free PMC Article
  2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphorylase kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription elongation factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Elongator complex protein 4
NP_001370473.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8016994..8018221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383133.2 → NP_001370473.1  Elongator complex protein 4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18195
    Conserved Domains (1) summary
    cd19494
    Location:19 → 256
    Elp4; Elongator subcomplex subunit Elp4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18195.1

Gene LinkOut

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