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ebp-1 microtubule End Binding Protein [ Caenorhabditis elegans ]

Gene ID: 3565059, updated on 2-Nov-2024

Summary

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Official Symbol
ebp-1
Official Full Name
microtubule End Binding Protein
Primary source
WormBase:WBGene00013344
Locus tag
CELE_Y59A8B.7
See related
AllianceGenome:WB:WBGene00013344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable microtubule plus-end binding activity. Predicted to be involved in protein localization to microtubule; regulation of microtubule polymerization or depolymerization; and spindle assembly. Located in cell cortex and microtubule cytoskeleton. Is expressed in neurons. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1); MAPRE2 (microtubule associated protein RP/EB family member 2); and MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ebp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (18043571..18052718)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Pre-mRNA-processing factor 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF727 domain-containing protein Neighboring gene EB1 C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. End-binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of dense core vesicles. Park J, et al. Curr Biol, 2023 Sep 25. PMID 37586371, Free PMC Article
  2. The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. Arimoto M, et al. J Neurosci, 2011 Feb 9. PMID 21307258, Free PMC Article
  3. Two phases of astral microtubule activity during cytokinesis in C. elegans embryos. Motegi F, et al. Dev Cell, 2006 Apr. PMID 16580995
  4. Imaging Epidermal Cell Rearrangement in the C. elegans Embryo. Hardin J, et al. Methods Mol Biol, 2022. PMID 35147953, Free PMC Article
  5. Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport. Barbosa DJ, et al. PLoS Genet, 2017 Jul. PMID 28759579, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
microtubule End Binding Protein
NP_507526.1
  • Product from WormBase gene class ebp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    18043571..18052718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075125.7 → NP_507526.1  microtubule End Binding Protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GRZ1
    Conserved Domains (3) summary
    COG5217
    Location:19 → 308
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    pfam03271
    Location:258 → 295
    EB1; EB1-like C-terminal motif
    cl00030
    Location:19 → 117
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Nucleotide Protein
Heading Accession and Version

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