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    mat-1 Cell division cycle protein 27 homolog [ Caenorhabditis elegans ]

    Gene ID: 172145, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mat-1
    Official Full Name
    Cell division cycle protein 27 homolog
    Primary source
    WormBase:WBGene00003132
    Locus tag
    CELE_Y110A7A.17
    See related
    AllianceGenome:WB:WBGene00003132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in asymmetric cell division; cortical granule exocytosis; and polarity specification of anterior/posterior axis. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mat-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (5123915..5127201, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Elongator complex protein 1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp31 Neighboring gene Fungal lipase-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast. Dong Y, et al. BMC Dev Biol, 2007 Mar 20. PMID 17374146, Free PMC Article
    2. Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities. Shakes DC, et al. Development, 2003 Apr. PMID 12620985, Free PMC Article
    3. Intermediate filaments in Caenorhabditis elegans. Fridkin A, et al. Methods Cell Biol, 2004. PMID 15646636
    4. EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans. Maruyama R, et al. Curr Biol, 2007 Sep 18. PMID 17869112
    5. Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans. Golden A, et al. J Cell Biol, 2000 Dec 25. PMID 11134076, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cell division cycle protein 27 homolog
    NP_001021714.1
    • Confirmed by transcript evidence
    NP_001364721.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5123915..5127201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377581.3 → NP_001364721.1  Cell division cycle protein 27 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      COG0457
      Location:453 → 631
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR02917
      Location:574 → 764
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:563 → 591
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:39 → 118
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    2. NM_001026543.8 → NP_001021714.1  Cell division cycle protein 27 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6AW18, Q8T4K4, Q9N593
      Conserved Domains (4) summary
      sd00006
      Location:561 → 589
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:39 → 118
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:595 → 660
      TPR_11; TPR repeat
      pfam14559
      Location:675 → 740
      TPR_19; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N593.1

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