hmr-1 Cadherin-related hmr-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmr-1
Official Full Name: Cadherin-related hmr-1
Primary source: WormBase:WBGene00001980
Locus tag: CELE_W02B9.1
See related: AllianceGenome:WB:WBGene00001980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Is expressed in several structures, including distal tip cell; hypodermis; nerve ring; neuroblasts; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hmr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 31

Sequence:: Chromosome: I; NC_003279.8 (11075758..11134667, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.
Title: Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.
HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex.
Title: Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin.
sax-7 and hmr-1 function redundantly in blastomere compaction and non-muscle myosin accumulation during C. elegans gastrulation.
Title: SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-192 (e-PCR)
- UniSTS:241683

Y52B11B.2 (e-PCR)
- UniSTS:312876

Y52B11B.1 (e-PCR)
- UniSTS:316215

ZK39.1 (e-PCR)
- UniSTS:312911

W02B9.1 (e-PCR)
- UniSTS:318574

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables delta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in apical constriction involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in distal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cadherin-related hmr-1

NP_001021650.1

Confirmed by transcript evidence

NP_001251561.1

Confirmed by transcript evidence

NP_001368105.1

Confirmed by transcript evidence

NP_001379266.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11075758..11134667 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026479.4 → NP_001021650.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021650.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2MZC5, H2FLJ9, H2FLK0, O44327, Q967F4

Conserved Domains (5) summary

cd11304
Location:647 → 742

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:2250 → 2283

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2286 → 2459

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:2812 → 2919

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:2533 → 2679

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001392947.1 → NP_001379266.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (5) summary

cd11304
Location:127 → 217

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:600 → 632

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:635 → 808

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:1161 → 1268

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:882 → 1028

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001264632.3 → NP_001251561.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251561.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q967F4

Conserved Domains (5) summary

cd11304
Location:26 → 129

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:395 → 427

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:430 → 603

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:956 → 1063

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:677 → 823

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001381216.1 → NP_001368105.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

cd00054
Location:265 → 297

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:300 → 473

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:826 → 933

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:547 → 693

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...