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Conserved domains on  [gi|1831506770|ref|NP_001368105|]
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Cadherin-related hmr-1 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 300-473 7.63e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 124.45  E-value: 7.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 300 TRSFGGNGFAWYKPMPA-CTSLNISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSmNGQSRSS 378
Cdd:cd00110     1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG---------GDFLALELEDGRLVLRYD-LGSGSLV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 379 LEvASTALNDGTWHDISVNQEGKRVELVVDNCRFLgagaddsscraELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTI 458
Cdd:cd00110    71 LS-SKTPLNDGQWHSVSVERNGRSVTLSVDGERVV-----------ESGSPGGSALLNLDGPLYLGGLPEDLKS--PGLP 136

                         170
                  ....*....|....*
gi 1831506770 459 PRAGLNGCVRNLNVN 473
Cdd:cd00110   137 VSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 265-297 7.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 7.03e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1831506770 265 QHSLCHNDGVCHNTNPGFFCECRnDGLKGARCQ 297
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 547-693 8.45e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00110:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 151  Bit Score: 43.56  E-value: 8.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 547 IQFAQGAFIEYsPRIAFPEQVSDIELLFISGKVNGAPaeLSFGTDSQQSYVSTNLESGQngVtaagKFDIGTGGRRARqe 626
Cdd:cd00110     2 VSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLL--LYAGSQNGGDFLALELEDGR--L----VLRYDLGSGSLV-- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831506770 627 LRVSEVLlkeNASYW--LQFTRNPTRASLSIDNAYTVSTQLDKGEPFSLQVNQITLG---------TQGQNKGFQGCI 693
Cdd:cd00110    71 LSSKTPL---NDGQWhsVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGglpedlkspGLPVSPGFVGCI 145
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 300-473 7.63e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 124.45  E-value: 7.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 300 TRSFGGNGFAWYKPMPA-CTSLNISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSmNGQSRSS 378
Cdd:cd00110     1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG---------GDFLALELEDGRLVLRYD-LGSGSLV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 379 LEvASTALNDGTWHDISVNQEGKRVELVVDNCRFLgagaddsscraELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTI 458
Cdd:cd00110    71 LS-SKTPLNDGQWHSVSVERNGRSVTLSVDGERVV-----------ESGSPGGSALLNLDGPLYLGGLPEDLKS--PGLP 136

                         170
                  ....*....|....*
gi 1831506770 459 PRAGLNGCVRNLNVN 473
Cdd:cd00110   137 VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
321-474 5.06e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.82  E-value: 5.06e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770  321 NISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEG 400
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG---------GDYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNG 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831506770  401 KRVELVVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPlsGQDYPQTIPRAGLNGCVRNLNVNG 474
Cdd:smart00282  71 RSVTLSVDGGN-----------RVSGESPGGLTILNLDGPLYLGGLPE--DLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 326-474 2.88e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.51  E-value: 2.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 326 FMTTQSDALLFYNGPletlrndthiEYSDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEGKRVEL 405
Cdd:pfam02210   1 FRTRQPNGLLLYAGG----------GGSDFLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831506770 406 VVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTIPRAGLNGCVRNLNVNG 474
Cdd:pfam02210  70 SVDGQT-----------VVSSLPPGESLLLNLNGPLYLGGLPPLLLL--PALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 265-297 7.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 7.03e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1831506770 265 QHSLCHNDGVCHNTNPGFFCECRnDGLKGARCQ 297
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 547-693 8.45e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 43.56  E-value: 8.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 547 IQFAQGAFIEYsPRIAFPEQVSDIELLFISGKVNGAPaeLSFGTDSQQSYVSTNLESGQngVtaagKFDIGTGGRRARqe 626
Cdd:cd00110     2 VSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLL--LYAGSQNGGDFLALELEDGR--L----VLRYDLGSGSLV-- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831506770 627 LRVSEVLlkeNASYW--LQFTRNPTRASLSIDNAYTVSTQLDKGEPFSLQVNQITLG---------TQGQNKGFQGCI 693
Cdd:cd00110    71 LSSKTPL---NDGQWhsVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGglpedlkspGLPVSPGFVGCI 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
265-297 7.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.48e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1831506770  265 QHSLCHNDGVCHNTNPGFFCECRNDGLKGARCQ 297
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 300-473 7.63e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 124.45  E-value: 7.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 300 TRSFGGNGFAWYKPMPA-CTSLNISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSmNGQSRSS 378
Cdd:cd00110     1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG---------GDFLALELEDGRLVLRYD-LGSGSLV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 379 LEvASTALNDGTWHDISVNQEGKRVELVVDNCRFLgagaddsscraELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTI 458
Cdd:cd00110    71 LS-SKTPLNDGQWHSVSVERNGRSVTLSVDGERVV-----------ESGSPGGSALLNLDGPLYLGGLPEDLKS--PGLP 136

                         170
                  ....*....|....*
gi 1831506770 459 PRAGLNGCVRNLNVN 473
Cdd:cd00110   137 VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
321-474 5.06e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.82  E-value: 5.06e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770  321 NISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEG 400
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGG---------GDYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNG 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831506770  401 KRVELVVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPlsGQDYPQTIPRAGLNGCVRNLNVNG 474
Cdd:smart00282  71 RSVTLSVDGGN-----------RVSGESPGGLTILNLDGPLYLGGLPE--DLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 326-474 2.88e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.51  E-value: 2.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 326 FMTTQSDALLFYNGPletlrndthiEYSDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEGKRVEL 405
Cdd:pfam02210   1 FRTRQPNGLLLYAGG----------GGSDFLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831506770 406 VVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTIPRAGLNGCVRNLNVNG 474
Cdd:pfam02210  70 SVDGQT-----------VVSSLPPGESLLLNLNGPLYLGGLPPLLLL--PALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
326-478 3.56e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 84.29  E-value: 3.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 326 FMTTQSDALLFYNGpletlrNDTHIeysDYIFIQLRGGRisLEVSMNGQSRSSLEVASTALNDGTWHDISVNQEGKRVEL 405
Cdd:pfam00054   1 FRTTEPSGLLLYNG------TQTER---DFLALELRDGR--LEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTL 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831506770 406 VVDNCrflgagadDSSCRAELYTPDDDerLNIVTPVQIGGLAPLSGQDYPQTIpRAGLNGCVRNLNVNGDQYD 478
Cdd:pfam00054  70 SVDGE--------ARPTGESPLGATTD--LDVDGPLYVGGLPSLGVKKRRLAI-SPSFDGCIRDVIVNGKPLD 131
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 265-297 7.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 7.03e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1831506770 265 QHSLCHNDGVCHNTNPGFFCECRnDGLKGARCQ 297
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 547-693 8.45e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 43.56  E-value: 8.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831506770 547 IQFAQGAFIEYsPRIAFPEQVSDIELLFISGKVNGAPaeLSFGTDSQQSYVSTNLESGQngVtaagKFDIGTGGRRARqe 626
Cdd:cd00110     2 VSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLL--LYAGSQNGGDFLALELEDGR--L----VLRYDLGSGSLV-- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831506770 627 LRVSEVLlkeNASYW--LQFTRNPTRASLSIDNAYTVSTQLDKGEPFSLQVNQITLG---------TQGQNKGFQGCI 693
Cdd:cd00110    71 LSSKTPL---NDGQWhsVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGglpedlkspGLPVSPGFVGCI 145
EGF_CA smart00179
Calcium-binding EGF-like domain;
265-297 7.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.48e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1831506770  265 QHSLCHNDGVCHNTNPGFFCECRNDGLKGARCQ 297
Cdd:smart00179   7 SGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 265-297 3.73e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1831506770 265 QHSLCHNDGVCHNTNPGFFCECRnDGLKGA-RCQ 297
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCP-PGYTGDrSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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