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Conserved domains on  [gi|71991933|ref|NP_001021650|]
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Cadherin-related hmr-1 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2286-2459 1.35e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.14  E-value: 1.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2286 TRSFGGNGFAWYKPMPA-CTSLNISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSmNGQSRSS 2364
Cdd:cd00110    1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG---------GDFLALELEDGRLVLRYD-LGSGSLV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2365 LEvASTALNDGTWHDISVNQEGKRVELVVDNCRFLgagaddsscraELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTI 2444
Cdd:cd00110   71 LS-SKTPLNDGQWHSVSVERNGRSVTLSVDGERVV-----------ESGSPGGSALLNLDGPLYLGGLPEDLKS--PGLP 136

                        170
                 ....*....|....*
gi 71991933 2445 PRAGLNGCVRNLNVN 2459
Cdd:cd00110  137 VSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 647-742 6.68e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 6.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  647 YTAQVREDIPLNQTILKVTAVDKDTGDNSRITYSVDNHN----FSINSN-GEISAKVRLDADQLNErhfvYRFNVTARDH 721
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedglFSIDPStGEITTAKPLDREEQSS----YTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 71991933  722 GEPvSLSSSAMIHIRTENTND 742
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1340-1432 1.72e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 1.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1340 YIGRVKESEGEGHDVITIKAHDLDKHSN--LRYHLIGaGGGRIPFGVRTDSGTIFVKEPLDFEASDQYHLVLIASDG--- 1414
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                         90
                 ....*....|....*...
gi 71991933 1415 RHNATTNVYIHIEDVNDN 1432
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1216-1331 2.99e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 2.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1216 FTGTIDEEMTPnehlektnGKPIVTVKAIDTDSdGPQNEVHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYI 1295
Cdd:cd11304    2 YEVSVPENAPP--------GTVVLTVSATDPDS-GENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 71991933 1296 LTVEASDrsvsalpGANGPNKDNVKVQIVINDVNDN 1331
Cdd:cd11304   70 LTVTATD-------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1553-1657 2.37e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 2.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1553 YIEENREPihsdGVYFMDVQARDFDDPttENANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVR 1632
Cdd:cd11304    5 SVPENAPP----GTVVLTVSATDPDSG--ENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 71991933 1633 ANDRGVPSREGFANVTIKVTDMNDN 1657
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1443-1542 7.11e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 7.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1443 TTVIEEDVDIPKVLFNVHATDADQDEkSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPPagvPSWNFVVQAIDDD 1522
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 71991933 1523 GNGLVGYADVQVNVRDINDN 1542
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 875-975 7.93e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 7.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  875 AKIMEGTyktdPP--TIVKVEATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPSphVVFDRETRPREDVTVKAT 952
Cdd:cd11304    4 VSVPENA----PPgtVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 71991933  953 DRGDRPLIGFCQFSVEVVDINDN 975
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 534-638 2.31e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 2.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  534 EYEVTVSEDNLVDYSVVDVKAQSfrsfEDGRSKGPITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDPAlpkLHKL 613
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATD----PDSGENGEVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQS---SYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 71991933  614 KVTAREDN---RESHVDLTIRIDDVNDN 638
Cdd:cd11304   71 TVTATDGGgppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1779-1868 2.40e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1779 RVREDVPRGTSIGRYTATDRDAGDTA--RFRInRQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNSNNI-- 1853
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGevTYSI-VSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPls 83

                         90
                 ....*....|....*
gi 71991933 1854 GRQMVAVYLQDVNDN 1868
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 983-1085 4.33e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 4.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  983 SYETSVSRFEAVGTSVITVFAFDNDAAHNAEITYSLeidttageEHQNDLDFFElVNRRSGEITLIKPIPM-KTQKFIFN 1061
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--------VSGNEDGLFS-IDPSTGEITTAKPLDReEQSSYTLT 71

                         90       100
                 ....*....|....*....|....
gi 71991933 1062 VIADDNGIPeALQSSAQVTLNVLD 1085
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 752-861 1.58e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  752 QYTAFVAEDAQGGTPVIQIQARDADRD---EVTYSFMDKNGrstqkMNLFSIDEHTGLVKLRHGVSaadlAEAENPINLT 828
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGengEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLD----REEQSSYTLT 71

                         90       100       110
                 ....*....|....*....|....*....|...
gi 71991933  829 VIVQDDGsccvypSKTHTSYATLLIGIEDVNNN 861
Cdd:cd11304   72 VTATDGG------GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1666-1768 3.82e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1666 YEGSVEETAPIGAAVMSFSAFDADEEAKDNVfTYQLSEESDYFYVTTDKDSkqssvGVLRVKQPLDYEdvtQRDGFHLGI 1745
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEV-TYSIVSGNEDGLFSIDPST-----GEITTAKPLDRE---EQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 71991933 1746 RVSDG---RHDAEAAVHVALVDRNDH 1768
Cdd:cd11304   73 TATDGggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1103-1206 4.86e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 4.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1103 ITVDENVELNKVILRCRAVSSGDSRNSDVIYKLTASGGPGnkaeskfrqfnKFE----NGnewvEVVIMEGLDYEQVNNY 1178
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----------LFSidpsTG----EITTAKPLDREEQSSY 68

                         90       100
                 ....*....|....*....|....*....
gi 71991933 1179 TLTLTATDM-TSRVASTKTFVVEVRDVND 1206
Cdd:cd11304   69 TLTVTATDGgGPPLSSTATVTITVLDVND 97
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2250-2283 3.19e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 3.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 71991933 2250 CQ-HSLCHNDGVCHNTNPGFFCECRnDGLKGARCQ 2283
Cdd:cd00054    5 CAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 431-521 3.34e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  431 AVVPLNPTIGRIVYQFVARDEHGDGDSNVLYKTIDVIPAGSFIVDPKSGVVRTGWS-KYERGDTYRISAQAmdlspSDNT 509
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPlDREEQSSYTLTVTA-----TDGG 78

                         90
                 ....*....|..
gi 71991933  510 TSQLSEVAILEI 521
Cdd:cd11304   79 GPPLSSTATVTI 90
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2533-2679 7.29e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00110:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2533 IQFAQGAFIEYsPRIAFPEQVSDIELLFISGKVNGAPaeLSFGTDSQQSYVSTNLESGQngVtaagKFDIGTGGRRARqe 2612
Cdd:cd00110    2 VSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLL--LYAGSQNGGDFLALELEDGR--L----VLRYDLGSGSLV-- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71991933 2613 LRVSEVLlkeNASYW--LQFTRNPTRASLSIDNAYTVSTQLDKGEPFSLQVNQITLG---------TQGQNKGFQGCI 2679
Cdd:cd00110   71 LSSKTPL---NDGQWhsVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGglpedlkspGLPVSPGFVGCI 145
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2286-2459 1.35e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.14  E-value: 1.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2286 TRSFGGNGFAWYKPMPA-CTSLNISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSmNGQSRSS 2364
Cdd:cd00110    1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG---------GDFLALELEDGRLVLRYD-LGSGSLV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2365 LEvASTALNDGTWHDISVNQEGKRVELVVDNCRFLgagaddsscraELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTI 2444
Cdd:cd00110   71 LS-SKTPLNDGQWHSVSVERNGRSVTLSVDGERVV-----------ESGSPGGSALLNLDGPLYLGGLPEDLKS--PGLP 136

                        170
                 ....*....|....*
gi 71991933 2445 PRAGLNGCVRNLNVN 2459
Cdd:cd00110  137 VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
2307-2460 8.61e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.51  E-value: 8.61e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    2307 NISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEG 2386
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG---------GDYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNG 70

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71991933    2387 KRVELVVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPlsGQDYPQTIPRAGLNGCVRNLNVNG 2460
Cdd:smart00282   71 RSVTLSVDGGN-----------RVSGESPGGLTILNLDGPLYLGGLPE--DLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2312-2460 1.65e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 106.74  E-value: 1.65e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   2312 FMTTQSDALLFYNGPletlrndthiEYSDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEGKRVEL 2391
Cdd:pfam02210    1 FRTRQPNGLLLYAGG----------GGSDFLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71991933   2392 VVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTIPRAGLNGCVRNLNVNG 2460
Cdd:pfam02210   70 SVDGQT-----------VVSSLPPGESLLLNLNGPLYLGGLPPLLLL--PALPVRAGFVGCIRDVRVNG 125
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 647-742 6.68e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 6.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  647 YTAQVREDIPLNQTILKVTAVDKDTGDNSRITYSVDNHN----FSINSN-GEISAKVRLDADQLNErhfvYRFNVTARDH 721
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedglFSIDPStGEITTAKPLDREEQSS----YTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 71991933  722 GEPvSLSSSAMIHIRTENTND 742
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1340-1432 1.72e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 1.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1340 YIGRVKESEGEGHDVITIKAHDLDKHSN--LRYHLIGaGGGRIPFGVRTDSGTIFVKEPLDFEASDQYHLVLIASDG--- 1414
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                         90
                 ....*....|....*...
gi 71991933 1415 RHNATTNVYIHIEDVNDN 1432
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1216-1331 2.99e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 2.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1216 FTGTIDEEMTPnehlektnGKPIVTVKAIDTDSdGPQNEVHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYI 1295
Cdd:cd11304    2 YEVSVPENAPP--------GTVVLTVSATDPDS-GENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 71991933 1296 LTVEASDrsvsalpGANGPNKDNVKVQIVINDVNDN 1331
Cdd:cd11304   70 LTVTATD-------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1553-1657 2.37e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 2.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1553 YIEENREPihsdGVYFMDVQARDFDDPttENANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVR 1632
Cdd:cd11304    5 SVPENAPP----GTVVLTVSATDPDSG--ENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 71991933 1633 ANDRGVPSREGFANVTIKVTDMNDN 1657
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1443-1542 7.11e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 7.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1443 TTVIEEDVDIPKVLFNVHATDADQDEkSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPPagvPSWNFVVQAIDDD 1522
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 71991933 1523 GNGLVGYADVQVNVRDINDN 1542
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 875-975 7.93e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 7.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  875 AKIMEGTyktdPP--TIVKVEATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPSphVVFDRETRPREDVTVKAT 952
Cdd:cd11304    4 VSVPENA----PPgtVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 71991933  953 DRGDRPLIGFCQFSVEVVDINDN 975
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 534-638 2.31e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 2.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  534 EYEVTVSEDNLVDYSVVDVKAQSfrsfEDGRSKGPITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDPAlpkLHKL 613
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATD----PDSGENGEVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQS---SYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 71991933  614 KVTAREDN---RESHVDLTIRIDDVNDN 638
Cdd:cd11304   71 TVTATDGGgppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1572-1659 2.36e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 2.36e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1572 QARDFDDPttENANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVRANDRGVPSREGFANVTIKV 1651
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 71991933    1652 TDMNDNAP 1659
Cdd:smart00112   74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1779-1868 2.40e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1779 RVREDVPRGTSIGRYTATDRDAGDTA--RFRInRQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNSNNI-- 1853
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGevTYSI-VSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPls 83

                         90
                 ....*....|....*
gi 71991933 1854 GRQMVAVYLQDVNDN 1868
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 983-1085 4.33e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 4.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  983 SYETSVSRFEAVGTSVITVFAFDNDAAHNAEITYSLeidttageEHQNDLDFFElVNRRSGEITLIKPIPM-KTQKFIFN 1061
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--------VSGNEDGLFS-IDPSTGEITTAKPLDReEQSSYTLT 71

                         90       100
                 ....*....|....*....|....
gi 71991933 1062 VIADDNGIPeALQSSAQVTLNVLD 1085
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 894-977 6.50e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.50e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     894 ATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPSphVVFDRETRPREDVTVKATDRGDRPLIGFCQFSVEVVDIN 973
Cdd:smart00112    2 ATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 71991933     974 DNSP 977
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1358-1434 6.69e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.69e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1358 KAHDLDKHSN--LRYHLIGaGGGRIPFGVRTDSGTIFVKEPLDFEASDQYHLVLIASDG---RHNATTNVYIHIEDVNDN 1432
Cdd:smart00112    1 SATDADSGENgkVTYSILS-GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDN 79


                    ..
gi 71991933    1433 AP 1434
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1246-1333 8.06e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 8.06e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1246 TDSDGPQN-EVHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYILTVEASDrsvsalpGANGPNKDNVKVQIV 1324
Cdd:smart00112    3 TDADSGENgKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATVTIT 72


                    ....*....
gi 71991933    1325 INDVNDNAP 1333
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
647-735 8.15e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 8.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    647 YTAQVREDIPLNQTILKVTAVDKDTGDNSRITYSV----DNHNFSIN-SNGEISAKVRLDADQLNErhfvYRFNVTARDH 721
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgggPGGNFRIDpDTGDISTTKPLDRESIGE----YELTVEATDS 76

                           90
                   ....*....|....
gi 71991933    722 GEPvSLSSSAMIHI 735
Cdd:pfam00028   77 GGP-PLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1460-1544 8.46e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 8.46e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1460 HATDADQDEkSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPpagVPSWNFVVQAIDDDGNGLVGYADVQVNVRDI 1539
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 71991933    1540 NDNSP 1544
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 752-861 1.58e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  752 QYTAFVAEDAQGGTPVIQIQARDADRD---EVTYSFMDKNGrstqkMNLFSIDEHTGLVKLRHGVSaadlAEAENPINLT 828
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGengEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLD----REEQSSYTLT 71

                         90       100       110
                 ....*....|....*....|....*....|...
gi 71991933  829 VIVQDDGsccvypSKTHTSYATLLIGIEDVNNN 861
Cdd:cd11304   72 VTATDGG------GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1779-1850 3.08e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 3.08e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71991933   1779 RVREDVPRGTSIGRYTATDRDAGD--TARFRInRQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNS 1850
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPngRIFYSI-LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1666-1768 3.82e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1666 YEGSVEETAPIGAAVMSFSAFDADEEAKDNVfTYQLSEESDYFYVTTDKDSkqssvGVLRVKQPLDYEdvtQRDGFHLGI 1745
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEV-TYSIVSGNEDGLFSIDPST-----GEITTAKPLDRE---EQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 71991933 1746 RVSDG---RHDAEAAVHVALVDRNDH 1768
Cdd:cd11304   73 TATDGggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1794-1870 3.85e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 3.85e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1794 TATDRDAGD--TARFRINrQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNSNNI--GRQMVAVYLQDVNDN 1868
Cdd:smart00112    1 SATDADSGEngKVTYSIL-SGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVNDN 79


                    ..
gi 71991933    1869 GP 1870
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 665-742 9.35e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 9.35e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     665 TAVDKDTGDNSRITYSV----DNHNFSINSN-GEISAKVRLDAdqlnERHFVYRFNVTARDHGEPvSLSSSAMIHIRTEN 739
Cdd:smart00112    1 SATDADSGENGKVTYSIlsgnDDGLFSIDPEtGEITTTKPLDR----EEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ...
gi 71991933     740 TND 742
Cdd:smart00112   76 VND 78
Cadherin pfam00028
Cadherin domain;
1554-1652 2.35e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 2.35e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1554 IEENREPihsdGVYFMDVQARDFDDPTteNANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVRA 1633
Cdd:pfam00028    5 VPENAPV----GTEVLTVTATDPDLGP--NGRIFYSILGG---GPGGNFRIDPDTGDISTTKPLDRE--SIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 71991933   1634 NDRGVPSREGFANVTIKVT 1652
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1340-1427 5.43e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 5.43e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1340 YIGRVKESEGEGHDVITIKAHDLDK--HSNLRYHLIGAGGGRIpFGVRTDSGTIFVKEPLDFEASDQYHLVLIASD-GRH 1416
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGP 79

                           90
                   ....*....|...
gi 71991933   1417 N--ATTNVYIHIE 1427
Cdd:pfam00028   80 PlsSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1235-1326 9.65e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 9.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1235 GKPIVTVKAidTDSDGPQNE-VHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYILTVEASDRSvsalpganG 1313
Cdd:pfam00028   12 GTEVLTVTA--TDPDLGPNGrIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--------G 78

                           90
                   ....*....|...
gi 71991933   1314 PNKDNVkVQIVIN 1326
Cdd:pfam00028   79 PPLSST-ATVTIT 90
Cadherin pfam00028
Cadherin domain;
1446-1536 1.38e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 1.38e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1446 IEEDVDIPKVLFNVHATDADqDEKSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPPagvPSWNFVVQAIDDDGNG 1525
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESI---GEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 71991933   1526 LVGYADVQVNV 1536
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 561-640 2.50e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 2.50e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     561 EDGRSKGPITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDpalPKLHKLKVTAR---EDNRESHVDLTIRIDDVND 637
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDG---LFSIDPETGEITTTKPLDREE---QPEYTLTVEATdggGPPLSSTATVTITVLDVND 78


                    ...
gi 71991933     638 NVP 640
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1103-1206 4.86e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 4.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1103 ITVDENVELNKVILRCRAVSSGDSRNSDVIYKLTASGGPGnkaeskfrqfnKFE----NGnewvEVVIMEGLDYEQVNNY 1178
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----------LFSidpsTG----EITTAKPLDREEQSSY 68

                         90       100
                 ....*....|....*....|....*....
gi 71991933 1179 TLTLTATDM-TSRVASTKTFVVEVRDVND 1206
Cdd:cd11304   69 TLTVTATDGgGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
875-969 6.00e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 6.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    875 AKIMEGtyKTDPPTIVKVEATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPspHVVFDRETRPREDVTVKATDR 954
Cdd:pfam00028    3 ASVPEN--APVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDIST--TKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 71991933    955 GDRPLIGFCQFSVEV 969
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
984-1084 1.77e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 1.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    984 YETSVSRFEAVGTSVITVFAFDNDAAHNAEITYSLeidtTAGEEHQNdldfFElVNRRSGEITLIKPI-PMKTQKFIFNV 1062
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI----LGGGPGGN----FR-IDPDTGDISTTKPLdRESIGEYELTV 71

                           90       100
                   ....*....|....*....|..
gi 71991933   1063 IADDNGIPeALQSSAQVTLNVL 1084
Cdd:pfam00028   72 EATDSGGP-PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1666-1750 8.35e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 8.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1666 YEGSVEETAPIGAAVMSFSAFDADEEAKDNVFTYQLS-EESDYFYVTTDKdskqssvGVLRVKQPLDYEdvtQRDGFHLG 1744
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDT-------GDISTTKPLDRE---SIGEYELT 70


                   ....*.
gi 71991933   1745 IRVSDG 1750
Cdd:pfam00028   71 VEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1003-1091 1.41e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 1.41e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1003 AFDNDAAHNAEITYSLEIDttageehqNDLDFFElVNRRSGEITLIKPIPM-KTQKFIFNVIADDNGIPeALQSSAQVTL 1081
Cdd:smart00112    2 ATDADSGENGKVTYSILSG--------NDDGLFS-IDPETGEITTTKPLDReEQPEYTLTVEATDGGGP-PLSSTATVTI 71

                            90
                    ....*....|
gi 71991933    1082 NVLDKQQKAP 1091
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
753-856 1.59e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    753 YTAFVAEDAQGGTPVIQIQARDADRDE---VTYSFMDKNGRstqkmNLFSIDEHTGLVKLRHGVSaadlAEAENPINLTV 829
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPG-----GNFRIDPDTGDISTTKPLD----RESIGEYELTV 71

                           90       100
                   ....*....|....*....|....*..
gi 71991933    830 IVQDDGSccvyPSKthTSYATLLIGIE 856
Cdd:pfam00028   72 EATDSGG----PPL--SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1684-1770 1.63e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 1.63e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1684 SAFDADEEAKDNVfTYQLSEESDYFYVTTDKDSkqssvGVLRVKQPLDYEdvtQRDGFHLGIRVSDG---RHDAEAAVHV 1760
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPET-----GEITTTKPLDRE---EQPEYTLTVEATDGggpPLSSTATVTI 71

                            90
                    ....*....|
gi 71991933    1761 ALVDRNDHAP 1770
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 771-863 1.15e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.50  E-value: 1.15e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     771 QARDADRDE---VTYSFMDKNGRstqkmNLFSIDEHTGLVKLRHGVSAadlaEAENPINLTVIVQDDGSccvypsKTHTS 847
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDD-----GLFSIDPETGEITTTKPLDR----EEQPEYTLTVEATDGGG------PPLSS 65

                            90
                    ....*....|....*.
gi 71991933     848 YATLLIGIEDVNNNKP 863
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2250-2283 3.19e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 3.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 71991933 2250 CQ-HSLCHNDGVCHNTNPGFFCECRnDGLKGARCQ 2283
Cdd:cd00054    5 CAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 431-521 3.34e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  431 AVVPLNPTIGRIVYQFVARDEHGDGDSNVLYKTIDVIPAGSFIVDPKSGVVRTGWS-KYERGDTYRISAQAmdlspSDNT 509
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPlDREEQSSYTLTVTA-----TDGG 78

                         90
                 ....*....|..
gi 71991933  510 TSQLSEVAILEI 521
Cdd:cd11304   79 GPPLSSTATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1119-1206 3.17e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 3.17e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1119 RAVSSGDSRNSDVIYKLTASGGPGNkaeskfrqFNKFENGNEwveVVIMEGLDYEQVNNYTLTLTATDMTSRVAS-TKTF 1197
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL--------FSIDPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPPLSsTATV 69


                    ....*....
gi 71991933    1198 VVEVRDVND 1206
Cdd:smart00112   70 TITVLDVND 78
EGF_CA smart00179
Calcium-binding EGF-like domain;
2250-2283 8.50e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 8.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 71991933    2250 CQ-HSLCHNDGVCHNTNPGFFCECRNDGLKGARCQ 2283
Cdd:smart00179    5 CAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
Cadherin pfam00028
Cadherin domain;
431-511 1.29e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    431 AVVPLNPTIGRIVYQFVARDEHGDGDSNVLYKTIDVIPAGSFIVDPKSGVVRTGWS-KYERGDTYRISAQAMDLS--PSD 507
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPlDRESIGEYELTVEATDSGgpPLS 82


                   ....
gi 71991933    508 NTTS 511
Cdd:pfam00028   83 STAT 86
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2533-2679 7.29e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2533 IQFAQGAFIEYsPRIAFPEQVSDIELLFISGKVNGAPaeLSFGTDSQQSYVSTNLESGQngVtaagKFDIGTGGRRARqe 2612
Cdd:cd00110    2 VSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLL--LYAGSQNGGDFLALELEDGR--L----VLRYDLGSGSLV-- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71991933 2613 LRVSEVLlkeNASYW--LQFTRNPTRASLSIDNAYTVSTQLDKGEPFSLQVNQITLG---------TQGQNKGFQGCI 2679
Cdd:cd00110   71 LSSKTPL---NDGQWhsVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGglpedlkspGLPVSPGFVGCI 145
Cadherin pfam00028
Cadherin domain;
1103-1201 7.99e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 40.75  E-value: 7.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1103 ITVDENVELNKVILRCRAVSSGDSRNSDVIYKLTaSGGPGNKaeskFRqFNKfENGnewvEVVIMEGLDYEQVNNYTLTL 1182
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGN----FR-IDP-DTG----DISTTKPLDRESIGEYELTV 71

                           90       100
                   ....*....|....*....|
gi 71991933   1183 TATDMTSR-VASTKTFVVEV 1201
Cdd:pfam00028   72 EATDSGGPpLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
535-632 1.82e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    535 YEVTVSEDNLVDYSVVDVKAQSfrsfedgRSKGP---ITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDPAlpkLH 611
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-------PDLGPngrIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIG---EY 67

                           90       100
                   ....*....|....*....|....
gi 71991933    612 KLKVTAR---EDNRESHVDLTIRI 632
Cdd:pfam00028   68 ELTVEATdsgGPPLSSTATVTITV 91
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2286-2459 1.35e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.14  E-value: 1.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2286 TRSFGGNGFAWYKPMPA-CTSLNISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSmNGQSRSS 2364
Cdd:cd00110    1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG---------GDFLALELEDGRLVLRYD-LGSGSLV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2365 LEvASTALNDGTWHDISVNQEGKRVELVVDNCRFLgagaddsscraELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTI 2444
Cdd:cd00110   71 LS-SKTPLNDGQWHSVSVERNGRSVTLSVDGERVV-----------ESGSPGGSALLNLDGPLYLGGLPEDLKS--PGLP 136

                        170
                 ....*....|....*
gi 71991933 2445 PRAGLNGCVRNLNVN 2459
Cdd:cd00110  137 VSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
2307-2460 8.61e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.51  E-value: 8.61e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    2307 NISFSFMTTQSDALLFYNGPLETlrndthieySDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEG 2386
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG---------GDYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNG 70

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71991933    2387 KRVELVVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPlsGQDYPQTIPRAGLNGCVRNLNVNG 2460
Cdd:smart00282   71 RSVTLSVDGGN-----------RVSGESPGGLTILNLDGPLYLGGLPE--DLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2312-2460 1.65e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 106.74  E-value: 1.65e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   2312 FMTTQSDALLFYNGPletlrndthiEYSDYIFIQLRGGRISLEVSMnGQSRSSLEVASTALNDGTWHDISVNQEGKRVEL 2391
Cdd:pfam02210    1 FRTRQPNGLLLYAGG----------GGSDFLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71991933   2392 VVDNCRflgagaddsscRAELYTPDDDERLNIVTPVQIGGLAPLSGQdyPQTIPRAGLNGCVRNLNVNG 2460
Cdd:pfam02210   70 SVDGQT-----------VVSSLPPGESLLLNLNGPLYLGGLPPLLLL--PALPVRAGFVGCIRDVRVNG 125
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 647-742 6.68e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 6.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  647 YTAQVREDIPLNQTILKVTAVDKDTGDNSRITYSVDNHN----FSINSN-GEISAKVRLDADQLNErhfvYRFNVTARDH 721
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedglFSIDPStGEITTAKPLDREEQSS----YTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 71991933  722 GEPvSLSSSAMIHIRTENTND 742
Cdd:cd11304   78 GGP-PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1340-1432 1.72e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 1.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1340 YIGRVKESEGEGHDVITIKAHDLDKHSN--LRYHLIGaGGGRIPFGVRTDSGTIFVKEPLDFEASDQYHLVLIASDG--- 1414
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggp 80

                         90
                 ....*....|....*...
gi 71991933 1415 RHNATTNVYIHIEDVNDN 1432
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1216-1331 2.99e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 2.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1216 FTGTIDEEMTPnehlektnGKPIVTVKAIDTDSdGPQNEVHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYI 1295
Cdd:cd11304    2 YEVSVPENAPP--------GTVVLTVSATDPDS-GENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 71991933 1296 LTVEASDrsvsalpGANGPNKDNVKVQIVINDVNDN 1331
Cdd:cd11304   70 LTVTATD-------GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1553-1657 2.37e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 2.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1553 YIEENREPihsdGVYFMDVQARDFDDPttENANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVR 1632
Cdd:cd11304    5 SVPENAPP----GTVVLTVSATDPDSG--ENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 71991933 1633 ANDRGVPSREGFANVTIKVTDMNDN 1657
Cdd:cd11304   74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1443-1542 7.11e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 7.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1443 TTVIEEDVDIPKVLFNVHATDADQDEkSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPPagvPSWNFVVQAIDDD 1522
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 71991933 1523 GNGLVGYADVQVNVRDINDN 1542
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 875-975 7.93e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 7.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  875 AKIMEGTyktdPP--TIVKVEATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPSphVVFDRETRPREDVTVKAT 952
Cdd:cd11304    4 VSVPENA----PPgtVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 71991933  953 DRGDRPLIGFCQFSVEVVDINDN 975
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 534-638 2.31e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 2.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  534 EYEVTVSEDNLVDYSVVDVKAQSfrsfEDGRSKGPITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDPAlpkLHKL 613
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATD----PDSGENGEVTYSIVSGNEDG---LFSIDPSTGEITTAKPLDREEQS---SYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 71991933  614 KVTAREDN---RESHVDLTIRIDDVNDN 638
Cdd:cd11304   71 TVTATDGGgppLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1572-1659 2.36e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 2.36e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1572 QARDFDDPttENANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVRANDRGVPSREGFANVTIKV 1651
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 71991933    1652 TDMNDNAP 1659
Cdd:smart00112   74 LDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1779-1868 2.40e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1779 RVREDVPRGTSIGRYTATDRDAGDTA--RFRInRQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNSNNI-- 1853
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGevTYSI-VSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPls 83

                         90
                 ....*....|....*
gi 71991933 1854 GRQMVAVYLQDVNDN 1868
Cdd:cd11304   84 STATVTITVLDVNDN 98
Laminin_G_1 pfam00054
Laminin G domain;
2312-2464 1.18e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 84.29  E-value: 1.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   2312 FMTTQSDALLFYNGpletlrNDTHIeysDYIFIQLRGGRisLEVSMNGQSRSSLEVASTALNDGTWHDISVNQEGKRVEL 2391
Cdd:pfam00054    1 FRTTEPSGLLLYNG------TQTER---DFLALELRDGR--LEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTL 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71991933   2392 VVDNCrflgagadDSSCRAELYTPDDDerLNIVTPVQIGGLAPLSGQDYPQTIpRAGLNGCVRNLNVNGDQYD 2464
Cdd:pfam00054   70 SVDGE--------ARPTGESPLGATTD--LDVDGPLYVGGLPSLGVKKRRLAI-SPSFDGCIRDVIVNGKPLD 131
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 983-1085 4.33e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.89  E-value: 4.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  983 SYETSVSRFEAVGTSVITVFAFDNDAAHNAEITYSLeidttageEHQNDLDFFElVNRRSGEITLIKPIPM-KTQKFIFN 1061
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--------VSGNEDGLFS-IDPSTGEITTAKPLDReEQSSYTLT 71

                         90       100
                 ....*....|....*....|....
gi 71991933 1062 VIADDNGIPeALQSSAQVTLNVLD 1085
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 894-977 6.50e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.50e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     894 ATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPSphVVFDRETRPREDVTVKATDRGDRPLIGFCQFSVEVVDIN 973
Cdd:smart00112    2 ATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 71991933     974 DNSP 977
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1358-1434 6.69e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.69e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1358 KAHDLDKHSN--LRYHLIGaGGGRIPFGVRTDSGTIFVKEPLDFEASDQYHLVLIASDG---RHNATTNVYIHIEDVNDN 1432
Cdd:smart00112    1 SATDADSGENgkVTYSILS-GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDN 79


                    ..
gi 71991933    1433 AP 1434
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1246-1333 8.06e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 8.06e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1246 TDSDGPQN-EVHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYILTVEASDrsvsalpGANGPNKDNVKVQIV 1324
Cdd:smart00112    3 TDADSGENgKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATVTIT 72


                    ....*....
gi 71991933    1325 INDVNDNAP 1333
Cdd:smart00112   73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
647-735 8.15e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 8.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    647 YTAQVREDIPLNQTILKVTAVDKDTGDNSRITYSV----DNHNFSIN-SNGEISAKVRLDADQLNErhfvYRFNVTARDH 721
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgggPGGNFRIDpDTGDISTTKPLDRESIGE----YELTVEATDS 76

                           90
                   ....*....|....
gi 71991933    722 GEPvSLSSSAMIHI 735
Cdd:pfam00028   77 GGP-PLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1460-1544 8.46e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 8.46e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1460 HATDADQDEkSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPpagVPSWNFVVQAIDDDGNGLVGYADVQVNVRDI 1539
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 71991933    1540 NDNSP 1544
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 752-861 1.58e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  752 QYTAFVAEDAQGGTPVIQIQARDADRD---EVTYSFMDKNGrstqkMNLFSIDEHTGLVKLRHGVSaadlAEAENPINLT 828
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGengEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLD----REEQSSYTLT 71

                         90       100       110
                 ....*....|....*....|....*....|...
gi 71991933  829 VIVQDDGsccvypSKTHTSYATLLIGIEDVNNN 861
Cdd:cd11304   72 VTATDGG------GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1779-1850 3.08e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 3.08e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71991933   1779 RVREDVPRGTSIGRYTATDRDAGD--TARFRInRQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNS 1850
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPngRIFYSI-LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1666-1768 3.82e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.42  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1666 YEGSVEETAPIGAAVMSFSAFDADEEAKDNVfTYQLSEESDYFYVTTDKDSkqssvGVLRVKQPLDYEdvtQRDGFHLGI 1745
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEV-TYSIVSGNEDGLFSIDPST-----GEITTAKPLDRE---EQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 71991933 1746 RVSDG---RHDAEAAVHVALVDRNDH 1768
Cdd:cd11304   73 TATDGggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1794-1870 3.85e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 3.85e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1794 TATDRDAGD--TARFRINrQSDPKRQFTIDQD-GTLRVAHTLDREDIAVYNLIIEAYDNSNNI--GRQMVAVYLQDVNDN 1868
Cdd:smart00112    1 SATDADSGEngKVTYSIL-SGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPlsSTATVTITVLDVNDN 79


                    ..
gi 71991933    1869 GP 1870
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 665-742 9.35e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 9.35e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     665 TAVDKDTGDNSRITYSV----DNHNFSINSN-GEISAKVRLDAdqlnERHFVYRFNVTARDHGEPvSLSSSAMIHIRTEN 739
Cdd:smart00112    1 SATDADSGENGKVTYSIlsgnDDGLFSIDPEtGEITTTKPLDR----EEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75


                    ...
gi 71991933     740 TND 742
Cdd:smart00112   76 VND 78
Cadherin pfam00028
Cadherin domain;
1554-1652 2.35e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 2.35e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1554 IEENREPihsdGVYFMDVQARDFDDPTteNANIEYGIVRNkliNGESVFRIDQNTGKIFAMRSLDREisSEREFIIEVRA 1633
Cdd:pfam00028    5 VPENAPV----GTEVLTVTATDPDLGP--NGRIFYSILGG---GPGGNFRIDPDTGDISTTKPLDRE--SIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 71991933   1634 NDRGVPSREGFANVTIKVT 1652
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1340-1427 5.43e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 5.43e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1340 YIGRVKESEGEGHDVITIKAHDLDK--HSNLRYHLIGAGGGRIpFGVRTDSGTIFVKEPLDFEASDQYHLVLIASD-GRH 1416
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGP 79

                           90
                   ....*....|...
gi 71991933   1417 N--ATTNVYIHIE 1427
Cdd:pfam00028   80 PlsSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1235-1326 9.65e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 9.65e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1235 GKPIVTVKAidTDSDGPQNE-VHYRIVGeanGEETKHFRIDELTGEIFPNEKFDREKIDMYILTVEASDRSvsalpganG 1313
Cdd:pfam00028   12 GTEVLTVTA--TDPDLGPNGrIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--------G 78

                           90
                   ....*....|...
gi 71991933   1314 PNKDNVkVQIVIN 1326
Cdd:pfam00028   79 PPLSST-ATVTIT 90
Cadherin pfam00028
Cadherin domain;
1446-1536 1.38e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 1.38e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1446 IEEDVDIPKVLFNVHATDADqDEKSSRIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPPagvPSWNFVVQAIDDDGNG 1525
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESI---GEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 71991933   1526 LVGYADVQVNV 1536
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 561-640 2.50e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 2.50e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     561 EDGRSKGPITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDpalPKLHKLKVTAR---EDNRESHVDLTIRIDDVND 637
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDG---LFSIDPETGEITTTKPLDREE---QPEYTLTVEATdggGPPLSSTATVTITVLDVND 78


                    ...
gi 71991933     638 NVP 640
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1103-1206 4.86e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.56  E-value: 4.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 1103 ITVDENVELNKVILRCRAVSSGDSRNSDVIYKLTASGGPGnkaeskfrqfnKFE----NGnewvEVVIMEGLDYEQVNNY 1178
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----------LFSidpsTG----EITTAKPLDREEQSSY 68

                         90       100
                 ....*....|....*....|....*....
gi 71991933 1179 TLTLTATDM-TSRVASTKTFVVEVRDVND 1206
Cdd:cd11304   69 TLTVTATDGgGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
875-969 6.00e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.08  E-value: 6.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    875 AKIMEGtyKTDPPTIVKVEATDDDSSANGDIVYSLyyTQSESRKAFVIDRQTGVLTPspHVVFDRETRPREDVTVKATDR 954
Cdd:pfam00028    3 ASVPEN--APVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDIST--TKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 71991933    955 GDRPLIGFCQFSVEV 969
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
984-1084 1.77e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.23  E-value: 1.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    984 YETSVSRFEAVGTSVITVFAFDNDAAHNAEITYSLeidtTAGEEHQNdldfFElVNRRSGEITLIKPI-PMKTQKFIFNV 1062
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI----LGGGPGGN----FR-IDPDTGDISTTKPLdRESIGEYELTV 71

                           90       100
                   ....*....|....*....|..
gi 71991933   1063 IADDNGIPeALQSSAQVTLNVL 1084
Cdd:pfam00028   72 EATDSGGP-PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1666-1750 8.35e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 52.30  E-value: 8.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1666 YEGSVEETAPIGAAVMSFSAFDADEEAKDNVFTYQLS-EESDYFYVTTDKdskqssvGVLRVKQPLDYEdvtQRDGFHLG 1744
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDT-------GDISTTKPLDRE---SIGEYELT 70


                   ....*.
gi 71991933   1745 IRVSDG 1750
Cdd:pfam00028   71 VEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1003-1091 1.41e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 1.41e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1003 AFDNDAAHNAEITYSLEIDttageehqNDLDFFElVNRRSGEITLIKPIPM-KTQKFIFNVIADDNGIPeALQSSAQVTL 1081
Cdd:smart00112    2 ATDADSGENGKVTYSILSG--------NDDGLFS-IDPETGEITTTKPLDReEQPEYTLTVEATDGGGP-PLSSTATVTI 71

                            90
                    ....*....|
gi 71991933    1082 NVLDKQQKAP 1091
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
753-856 1.59e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    753 YTAFVAEDAQGGTPVIQIQARDADRDE---VTYSFMDKNGRstqkmNLFSIDEHTGLVKLRHGVSaadlAEAENPINLTV 829
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPG-----GNFRIDPDTGDISTTKPLD----RESIGEYELTV 71

                           90       100
                   ....*....|....*....|....*..
gi 71991933    830 IVQDDGSccvyPSKthTSYATLLIGIE 856
Cdd:pfam00028   72 EATDSGG----PPL--SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1684-1770 1.63e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 1.63e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1684 SAFDADEEAKDNVfTYQLSEESDYFYVTTDKDSkqssvGVLRVKQPLDYEdvtQRDGFHLGIRVSDG---RHDAEAAVHV 1760
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPET-----GEITTTKPLDRE---EQPEYTLTVEATDGggpPLSSTATVTI 71

                            90
                    ....*....|
gi 71991933    1761 ALVDRNDHAP 1770
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 771-863 1.15e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.50  E-value: 1.15e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933     771 QARDADRDE---VTYSFMDKNGRstqkmNLFSIDEHTGLVKLRHGVSAadlaEAENPINLTVIVQDDGSccvypsKTHTS 847
Cdd:smart00112    1 SATDADSGEngkVTYSILSGNDD-----GLFSIDPETGEITTTKPLDR----EEQPEYTLTVEATDGGG------PPLSS 65

                            90
                    ....*....|....*.
gi 71991933     848 YATLLIGIEDVNNNKP 863
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2250-2283 3.19e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 3.19e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 71991933 2250 CQ-HSLCHNDGVCHNTNPGFFCECRnDGLKGARCQ 2283
Cdd:cd00054    5 CAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 431-521 3.34e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933  431 AVVPLNPTIGRIVYQFVARDEHGDGDSNVLYKTIDVIPAGSFIVDPKSGVVRTGWS-KYERGDTYRISAQAmdlspSDNT 509
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPlDREEQSSYTLTVTA-----TDGG 78

                         90
                 ....*....|..
gi 71991933  510 TSQLSEVAILEI 521
Cdd:cd11304   79 GPPLSSTATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1119-1206 3.17e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 3.17e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    1119 RAVSSGDSRNSDVIYKLTASGGPGNkaeskfrqFNKFENGNEwveVVIMEGLDYEQVNNYTLTLTATDMTSRVAS-TKTF 1197
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGL--------FSIDPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPPLSsTATV 69


                    ....*....
gi 71991933    1198 VVEVRDVND 1206
Cdd:smart00112   70 TITVLDVND 78
EGF_CA smart00179
Calcium-binding EGF-like domain;
2250-2283 8.50e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 8.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 71991933    2250 CQ-HSLCHNDGVCHNTNPGFFCECRNDGLKGARCQ 2283
Cdd:smart00179    5 CAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2250-2283 9.87e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 41.69  E-value: 9.87e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 71991933 2250 CQ-HSLCHNDGVCHNTNPGFFCECRnDGLKGA-RCQ 2283
Cdd:cd00053    2 CAaSNPCSNGGTCVNTPGSYRCVCP-PGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
431-511 1.29e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    431 AVVPLNPTIGRIVYQFVARDEHGDGDSNVLYKTIDVIPAGSFIVDPKSGVVRTGWS-KYERGDTYRISAQAMDLS--PSD 507
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPlDRESIGEYELTVEATDSGgpPLS 82


                   ....
gi 71991933    508 NTTS 511
Cdd:pfam00028   83 STAT 86
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2533-2679 7.29e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 42.41  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933 2533 IQFAQGAFIEYsPRIAFPEQVSDIELLFISGKVNGAPaeLSFGTDSQQSYVSTNLESGQngVtaagKFDIGTGGRRARqe 2612
Cdd:cd00110    2 VSFSGSSYVRL-PTLPAPRTRLSISFSFRTTSPNGLL--LYAGSQNGGDFLALELEDGR--L----VLRYDLGSGSLV-- 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71991933 2613 LRVSEVLlkeNASYW--LQFTRNPTRASLSIDNAYTVSTQLDKGEPFSLQVNQITLG---------TQGQNKGFQGCI 2679
Cdd:cd00110   71 LSSKTPL---NDGQWhsVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGglpedlkspGLPVSPGFVGCI 145
Cadherin pfam00028
Cadherin domain;
1103-1201 7.99e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 40.75  E-value: 7.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933   1103 ITVDENVELNKVILRCRAVSSGDSRNSDVIYKLTaSGGPGNKaeskFRqFNKfENGnewvEVVIMEGLDYEQVNNYTLTL 1182
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGN----FR-IDP-DTG----DISTTKPLDRESIGEYELTV 71

                           90       100
                   ....*....|....*....|
gi 71991933   1183 TATDMTSR-VASTKTFVVEV 1201
Cdd:pfam00028   72 EATDSGGPpLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
535-632 1.82e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991933    535 YEVTVSEDNLVDYSVVDVKAQSfrsfedgRSKGP---ITYSLEGDTPEDetkWFRIDPSTGIIHLTRLLDFDDPAlpkLH 611
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-------PDLGPngrIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIG---EY 67

                           90       100
                   ....*....|....*....|....
gi 71991933    612 KLKVTAR---EDNRESHVDLTIRI 632
Cdd:pfam00028   68 ELTVEATdsgGPPLSSTATVTITV 91
EGF smart00181
Epidermal growth factor-like domain;
2250-2283 6.51e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 6.51e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 71991933    2250 CQ-HSLCHNdGVCHNTNPGFFCECRnDGLKGA-RCQ 2283
Cdd:smart00181    2 CAsGGPCSN-GTCINTPGSYTCSCP-PGYTGDkRCE 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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