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    SESN2 sestrin 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 509863, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SESN2provided by VGNC
    Official Full Name
    sestrin 2provided by VGNC
    Primary source
    VGNC:VGNC:34489
    See related
    BGD:BT16842; Ensembl:ENSBTAG00000002363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SESN2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (125114002..125131744, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene mediator complex subunit 18 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells. Luo C, et al. J Agric Food Chem, 2019 May 1. PMID 30969118
    2. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SESN2 negatively regulates the mTORC1 pathway and subsequent CSN2 synthesis through the SH3BP4 in response to amino acids depletion.
      Title: Sestrin2 Negatively Regulates Casein Synthesis through the SH3BP4-mTORC1 Pathway in Response to AA Depletion or Supplementation in Cow Mammary Epithelial Cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC140133

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-leucine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on peroxide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to leucine starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sestrin-2
    NP_001019678.1
    XP_005203155.1
    XP_010800833.1
    XP_010800835.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024507.1 → NP_001019678.1  sestrin-2

      See identical proteins and their annotated locations for NP_001019678.1

      Status: PROVISIONAL

      Source sequence(s)
      BT021909
      UniProtKB/TrEMBL
      A0AAA9S9J8
      Conserved Domains (1) summary
      pfam04636
      Location:34 → 444
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      125114002..125131744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010802531.4 → XP_010800833.1  sestrin-2 isoform X2

      UniProtKB/TrEMBL
      A0AAA9S9J8, A0AAF6ZDY8
      Related
      ENSBTAP00000040490.4, ENSBTAT00000042886.5
      Conserved Domains (1) summary
      pfam04636
      Location:20 → 448
      PA26; PA26 p53-induced protein (sestrin)

    2. XM_010802533.4 → XP_010800835.1  sestrin-2 isoform X3

      Conserved Domains (1) summary
      pfam04636
      Location:34 → 399
      PA26; PA26 p53-induced protein (sestrin)

    3. XM_005203098.3 → XP_005203155.1  sestrin-2 isoform X1

      See identical proteins and their annotated locations for XP_005203155.1

      UniProtKB/Swiss-Prot
      Q08E69, Q58CN8
      UniProtKB/TrEMBL
      A0AAA9S9J8
      Related
      ENSBTAP00000084602.1, ENSBTAT00000114730.1
      Conserved Domains (1) summary
      pfam04636
      Location:34 → 470
      PA26; PA26 p53-induced protein (sestrin)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58CN8.2 GenPept UniProtKB/Swiss-Prot:Q58CN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.