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Conserved domains on  [gi|66792736|ref|NP_001019678|]
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sestrin-2 [Bos taurus]

Protein Classification

sestrin( domain architecture ID 10519211)

sestrin functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
34-444 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


:

Pssm-ID: 461375  Cd Length: 442  Bit Score: 716.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736    34 GPSAFIPVEEVLQEGAES-LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAA 112
Cdd:pfam04636   1 GPSSFIPEKEILQESTEDeRTQQLFVEAFLSLGRVDHITQVMGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   113 RHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLL 192
Cdd:pfam04636  81 RHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDELNKLLAHRPWLITKEHIEALLKGGEDSWSLAELVHAVVLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   193 THCHSLASFVFGCGILPEGDPEGSPA------PQAPSPPSEQSTPPSRDSLNHSGGFEAARDVEALMERMRQLQESLLqD 266
Cdd:pfam04636 161 AHFHSLASFVFGCGINPEVDLEGGHTfqppspTSPCNIGNGNSSPPSDLELGRSAASDSEIEVEALMERMKKLQEEQD-E 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   267 EGASQEEMESRFELEKSESLLVtPSVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRARDYTWEDHGYSLIQRL 346
Cdd:pfam04636 240 EEASQEEMSTRFEKEESESLLV-PSSSILESAPPSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   347 YPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKT 426
Cdd:pfam04636 319 YPDIGQLLDEKFRVAYNLTYNTMAMHKGVDTSMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKT 398
                         410
                  ....*....|....*...
gi 66792736   427 TRRMYNHFWRHFRHSEKV 444
Cdd:pfam04636 399 TTRDYDSFWRQFKHSEKV 416
 
Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
34-444 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


Pssm-ID: 461375  Cd Length: 442  Bit Score: 716.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736    34 GPSAFIPVEEVLQEGAES-LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAA 112
Cdd:pfam04636   1 GPSSFIPEKEILQESTEDeRTQQLFVEAFLSLGRVDHITQVMGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   113 RHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLL 192
Cdd:pfam04636  81 RHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDELNKLLAHRPWLITKEHIEALLKGGEDSWSLAELVHAVVLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   193 THCHSLASFVFGCGILPEGDPEGSPA------PQAPSPPSEQSTPPSRDSLNHSGGFEAARDVEALMERMRQLQESLLqD 266
Cdd:pfam04636 161 AHFHSLASFVFGCGINPEVDLEGGHTfqppspTSPCNIGNGNSSPPSDLELGRSAASDSEIEVEALMERMKKLQEEQD-E 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   267 EGASQEEMESRFELEKSESLLVtPSVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRARDYTWEDHGYSLIQRL 346
Cdd:pfam04636 240 EEASQEEMSTRFEKEESESLLV-PSSSILESAPPSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   347 YPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKT 426
Cdd:pfam04636 319 YPDIGQLLDEKFRVAYNLTYNTMAMHKGVDTSMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKT 398
                         410
                  ....*....|....*...
gi 66792736   427 TRRMYNHFWRHFRHSEKV 444
Cdd:pfam04636 399 TTRDYDSFWRQFKHSEKV 416
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
65-186 5.06e-04

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 40.86  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736    65 GRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDP---EWLLGLH 141
Cdd:TIGR01926  27 GFVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPdlaDAVAVNF 106
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 66792736   142 RA---PEKLRKLSEINKLLAHRPWLITKEHIQALLKTG---EHSWSLAELI 186
Cdd:TIGR01926 107 RDadlSPRERAMLDFAVKLTATPAKVNEADFAALRAAGfsdLDILDLIHSV 157
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
77-174 2.28e-03

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 38.32  E-value: 2.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736  77 HPDYFTSFWRLHcLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAP------EKLRKL 150
Cdd:COG2128   2 SPELLKAFLALS-GALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWResplfdPRERAA 80
                        90       100
                ....*....|....*....|....
gi 66792736 151 SEINKLLAHRPWLITKEHIQALLK 174
Cdd:COG2128  81 LAFAEALTRTPGGVSDADVAALRA 104
 
Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
34-444 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


Pssm-ID: 461375  Cd Length: 442  Bit Score: 716.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736    34 GPSAFIPVEEVLQEGAES-LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAA 112
Cdd:pfam04636   1 GPSSFIPEKEILQESTEDeRTQQLFVEAFLSLGRVDHITQVMGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   113 RHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLL 192
Cdd:pfam04636  81 RHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDELNKLLAHRPWLITKEHIEALLKGGEDSWSLAELVHAVVLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   193 THCHSLASFVFGCGILPEGDPEGSPA------PQAPSPPSEQSTPPSRDSLNHSGGFEAARDVEALMERMRQLQESLLqD 266
Cdd:pfam04636 161 AHFHSLASFVFGCGINPEVDLEGGHTfqppspTSPCNIGNGNSSPPSDLELGRSAASDSEIEVEALMERMKKLQEEQD-E 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   267 EGASQEEMESRFELEKSESLLVtPSVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRARDYTWEDHGYSLIQRL 346
Cdd:pfam04636 240 EEASQEEMSTRFEKEESESLLV-PSSSILESAPPSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736   347 YPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKT 426
Cdd:pfam04636 319 YPDIGQLLDEKFRVAYNLTYNTMAMHKGVDTSMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKT 398
                         410
                  ....*....|....*...
gi 66792736   427 TRRMYNHFWRHFRHSEKV 444
Cdd:pfam04636 399 TTRDYDSFWRQFKHSEKV 416
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
65-186 5.06e-04

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 40.86  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736    65 GRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDP---EWLLGLH 141
Cdd:TIGR01926  27 GFVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPdlaDAVAVNF 106
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 66792736   142 RA---PEKLRKLSEINKLLAHRPWLITKEHIQALLKTG---EHSWSLAELI 186
Cdd:TIGR01926 107 RDadlSPRERAMLDFAVKLTATPAKVNEADFAALRAAGfsdLDILDLIHSV 157
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
77-174 2.28e-03

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 38.32  E-value: 2.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66792736  77 HPDYFTSFWRLHcLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAP------EKLRKL 150
Cdd:COG2128   2 SPELLKAFLALS-GALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWResplfdPRERAA 80
                        90       100
                ....*....|....*....|....
gi 66792736 151 SEINKLLAHRPWLITKEHIQALLK 174
Cdd:COG2128  81 LAFAEALTRTPGGVSDADVAALRA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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