NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|741918301|ref|XP_010800835|]
View 

sestrin-2 isoform X3 [Bos taurus]

Protein Classification

sestrin( domain architecture ID 10519211)

sestrin functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
34-399 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


:

Pssm-ID: 461375  Cd Length: 442  Bit Score: 653.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301   34 GPSAFIPVEEVLQEGAES-LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAA 112
Cdd:pfam04636   1 GPSSFIPEKEILQESTEDeRTQQLFVEAFLSLGRVDHITQVMGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  113 RHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQ---------------------- 170
Cdd:pfam04636  81 RHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDELNKLLAHRPWLITKEHIEallkggedswslaelvhavvll 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  171 -------------------------------------------------------GFEAARDVEALMERMRQLQESLLqD 195
Cdd:pfam04636 161 ahfhslasfvfgcginpevdlegghtfqppsptspcnigngnssppsdlelgrsaASDSEIEVEALMERMKKLQEEQD-E 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  196 EGASQEEMESRFELEKSESLLVtPSVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRL 275
Cdd:pfam04636 240 EEASQEEMSTRFEKEESESLLV-PSSSILESAPPSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  276 YPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKT 355
Cdd:pfam04636 319 YPDIGQLLDEKFRVAYNLTYNTMAMHKGVDTSMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKT 398
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 741918301  356 TRRMYNHFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYM 399
Cdd:pfam04636 399 TTRDYDSFWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRYM 442
 
Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
34-399 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


Pssm-ID: 461375  Cd Length: 442  Bit Score: 653.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301   34 GPSAFIPVEEVLQEGAES-LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAA 112
Cdd:pfam04636   1 GPSSFIPEKEILQESTEDeRTQQLFVEAFLSLGRVDHITQVMGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  113 RHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQ---------------------- 170
Cdd:pfam04636  81 RHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDELNKLLAHRPWLITKEHIEallkggedswslaelvhavvll 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  171 -------------------------------------------------------GFEAARDVEALMERMRQLQESLLqD 195
Cdd:pfam04636 161 ahfhslasfvfgcginpevdlegghtfqppsptspcnigngnssppsdlelgrsaASDSEIEVEALMERMKKLQEEQD-E 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  196 EGASQEEMESRFELEKSESLLVtPSVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRL 275
Cdd:pfam04636 240 EEASQEEMSTRFEKEESESLLV-PSSSILESAPPSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  276 YPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKT 355
Cdd:pfam04636 319 YPDIGQLLDEKFRVAYNLTYNTMAMHKGVDTSMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKT 398
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 741918301  356 TRRMYNHFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYM 399
Cdd:pfam04636 399 TTRDYDSFWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRYM 442
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
65-135 1.12e-03

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 39.70  E-value: 1.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741918301   65 GRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPE 135
Cdd:TIGR01926  27 GFVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPD 97
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
77-145 6.10e-03

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 36.78  E-value: 6.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741918301  77 HPDYFTSFWRLHcLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPE 145
Cdd:COG2128    2 SPELLKAFLALS-GALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRE 69
 
Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
34-399 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


Pssm-ID: 461375  Cd Length: 442  Bit Score: 653.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301   34 GPSAFIPVEEVLQEGAES-LEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAA 112
Cdd:pfam04636   1 GPSSFIPEKEILQESTEDeRTQQLFVEAFLSLGRVDHITQVMGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  113 RHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQ---------------------- 170
Cdd:pfam04636  81 RHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDELNKLLAHRPWLITKEHIEallkggedswslaelvhavvll 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  171 -------------------------------------------------------GFEAARDVEALMERMRQLQESLLqD 195
Cdd:pfam04636 161 ahfhslasfvfgcginpevdlegghtfqppsptspcnigngnssppsdlelgrsaASDSEIEVEALMERMKKLQEEQD-E 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  196 EGASQEEMESRFELEKSESLLVtPSVDILEPFANPDMLCFVEDPTFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRL 275
Cdd:pfam04636 240 EEASQEEMSTRFEKEESESLLV-PSSSILESAPPSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741918301  276 YPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKT 355
Cdd:pfam04636 319 YPDIGQLLDEKFRVAYNLTYNTMAMHKGVDTSMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKT 398
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 741918301  356 TRRMYNHFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYM 399
Cdd:pfam04636 399 TTRDYDSFWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRYM 442
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
65-135 1.12e-03

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 39.70  E-value: 1.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 741918301   65 GRVDNLAVVMGLHPDYFTSFWRLHCLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPE 135
Cdd:TIGR01926  27 GFVPNVFRALAHDPEALRARTAYFNDLMLGEGGLSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPD 97
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
77-145 6.10e-03

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 36.78  E-value: 6.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 741918301  77 HPDYFTSFWRLHcLLLHTDGPLANSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPE 145
Cdd:COG2128    2 SPELLKAFLALS-GALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRE 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH