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    HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 695571, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HERC4provided by VGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 4provided by VGNC
    Primary source
    VGNC:VGNC:106056
    See related
    Ensembl:ENSMMUG00000010105
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HERC4 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (69848820..70001871)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (64523136..64676084)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene uncharacterized LOC114670131 Neighboring gene POU domain, class 5, transcription factor 1-like Neighboring gene sirtuin 1 Neighboring gene protein DEK pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC4
    Names
    hect domain and RLD 4
    putative E3 ubiquitin-protein ligase HERC4
    NP_001244507.1
    XP_015002818.1
    XP_015002822.1
    XP_015002823.1
    XP_028709107.1
    XP_028709108.1
    XP_028709109.1
    XP_028709110.1
    XP_028709111.1
    XP_028709113.1
    XP_028709114.1
    XP_028709115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257578.1 → NP_001244507.1  probable E3 ubiquitin-protein ligase HERC4

      See identical proteins and their annotated locations for NP_001244507.1

      Status: PROVISIONAL

      Source sequence(s)
      JU321364
      UniProtKB/TrEMBL
      F7GN82, G7N2D0, H9ERW1
      Related
      ENSMMUP00000005917.4, ENSMMUT00000006290.4
      Conserved Domains (2) summary
      COG5184
      Location:2 → 344
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:709 → 1055
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      69848820..70001871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028853274.1 → XP_028709107.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      UniProtKB/TrEMBL
      G7N2D0
      Conserved Domains (3) summary
      COG5184
      Location:2 → 368
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:775 → 1121
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:669 → 712
      Ribosomal_S3Ae; Ribosomal S3Ae family

    2. XM_015147332.2 → XP_015002818.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

      UniProtKB/TrEMBL
      G7N2D0
      Conserved Domains (3) summary
      smart00119
      Location:759 → 1078
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:733 → 1079
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:232 → 281
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    3. XM_015147336.2 → XP_015002822.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

      UniProtKB/TrEMBL
      G7N2D0
      Conserved Domains (3) summary
      smart00119
      Location:751 → 1070
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:725 → 1071
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:232 → 281
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    4. XM_028853276.1 → XP_028709109.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

      UniProtKB/TrEMBL
      G7N2D0
      Conserved Domains (3) summary
      COG5184
      Location:2 → 344
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:751 → 1097
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:645 → 688
      Ribosomal_S3Ae; Ribosomal S3Ae family

    5. XM_015147337.2 → XP_015002823.1  probable E3 ubiquitin-protein ligase HERC4 isoform X8

      UniProtKB/TrEMBL
      F6R799, G7N2D0, H9YZ98
      Related
      ENSMMUP00000013211.4, ENSMMUT00000014107.4
      Conserved Domains (3) summary
      smart00119
      Location:727 → 1046
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:701 → 1047
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00415
      Location:208 → 257
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    6. XM_028853280.1 → XP_028709113.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

      UniProtKB/TrEMBL
      F7FBK1
      Conserved Domains (3) summary
      COG5184
      Location:4 → 293
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:706 → 1052
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:600 → 643
      Ribosomal_S3Ae; Ribosomal S3Ae family

    7. XM_028853277.1 → XP_028709110.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

      UniProtKB/TrEMBL
      F7FBK1
      Conserved Domains (3) summary
      COG5184
      Location:35 → 315
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:728 → 1074
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:622 → 665
      Ribosomal_S3Ae; Ribosomal S3Ae family

    8. XM_028853281.1 → XP_028709114.1  probable E3 ubiquitin-protein ligase HERC4 isoform X7

      UniProtKB/TrEMBL
      F7FBK1
      Conserved Domains (3) summary
      COG5184
      Location:12 → 292
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:705 → 1051
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:599 → 642
      Ribosomal_S3Ae; Ribosomal S3Ae family

    9. XM_028853282.1 → XP_028709115.1  probable E3 ubiquitin-protein ligase HERC4 isoform X9

      UniProtKB/TrEMBL
      F7FBK1
      Related
      ENSMMUP00000035810.3, ENSMMUT00000042798.3
      Conserved Domains (3) summary
      COG5184
      Location:12 → 268
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:681 → 1027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:575 → 618
      Ribosomal_S3Ae; Ribosomal S3Ae family

    10. XM_028853275.1 → XP_028709108.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

      UniProtKB/TrEMBL
      G7N2D0
      Conserved Domains (3) summary
      COG5184
      Location:2 → 368
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:775 → 1121
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:669 → 712
      Ribosomal_S3Ae; Ribosomal S3Ae family

    11. XM_028853278.1 → XP_028709111.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

      UniProtKB/TrEMBL
      F7FBK1
      Conserved Domains (3) summary
      COG5184
      Location:35 → 315
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:728 → 1074
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cl00821
      Location:622 → 665
      Ribosomal_S3Ae; Ribosomal S3Ae family

    RNA

    1. XR_003732768.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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