NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622962965|ref|XP_028709111|]
View 

probable E3 ubiquitin-protein ligase HERC4 isoform X4 [Macaca mulatta]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18804227)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 728-1074 2.39e-145

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 438.92  E-value: 2.39e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  728 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 806
Cdd:cd00078      1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  807 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 883
Cdd:cd00078     81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  884 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 962
Cdd:cd00078    159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  963 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPV 1040
Cdd:cd00078    239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1622962965 1041 SHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFS 1074
Cdd:cd00078    319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-315 4.22e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 221.00  E-value: 4.22e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   38 NIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLlGSEECIRVPsclpkimcvdsvVRICSGLSygrirnikslsdiQII 117
Cdd:COG5184     99 GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTP------------VQVDAGLS-------------GVV 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  118 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFG 197
Cdd:COG5184    153 AIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  198 QLGLNDENDRYVPNLLKSLrsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIA 277
Cdd:COG5184    230 QLGDGTTTDRATPVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVA 305

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1622962965  278 CGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 315
Cdd:COG5184    306 AGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 728-1074 2.39e-145

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 438.92  E-value: 2.39e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  728 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 806
Cdd:cd00078      1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  807 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 883
Cdd:cd00078     81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  884 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 962
Cdd:cd00078    159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  963 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPV 1040
Cdd:cd00078    239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1622962965 1041 SHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFS 1074
Cdd:cd00078    319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 754-1073 2.51e-113

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 353.85  E-value: 2.51e-113
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   754 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSD----LFHLIGVICGLAIYNFT 829
Cdd:smart00119    4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEehlsYFRFIGRVLGKALYDNR 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   830 IVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL-LDYPEDDIEEtfcLNFTITVEN-FGATEVKELVLNGADTAV 907
Cdd:smart00119   84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSNIPV 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   908 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 987
Cdd:smart00119  161 TEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQT 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   988 IKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQ 1065
Cdd:smart00119  241 IKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLL 320


                    ....*...
gi 1622962965  1066 AIDHNEGF 1073
Cdd:smart00119  321 AINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 778-1076 1.69e-104

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 329.57  E-value: 1.69e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  778 LLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFED-----SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLD 851
Cdd:pfam00632    1 TLLSKELFDPNYGLFEYeTEDDRTYWFNPSSSESpdlelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  852 DLKELMPDVGRSMQQLLDYpEDDIEETFCLNFTITVenFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASL 931
Cdd:pfam00632   81 DLESIDPELYKSLKSLLNM-DNDDDEDLGLTFTIPV--FGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQ 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  932 FDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKQQFLLFLT 1011
Cdd:pfam00632  158 LEAFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVT 237

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622962965 1012 GSDRIPILGMKSL-KLVIQSTGG-GEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI 1076
Cdd:pfam00632  238 GSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
679-1076 1.98e-90

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 309.39  E-value: 1.98e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  679 TYPFVFDAQAKTTLLQTD-----AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKN 750
Cdd:COG5021    458 LYRFYFVEHRKKTLTKNDsrlgsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESG 537

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  751 IDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIW----FSDKTFEDSDLFHLIGVICGLAIY 826
Cdd:COG5021    538 DDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIY 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  827 NFTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNFTITVENFGATEVKELVLNGADTA 906
Cdd:COG5021    618 DSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNIS 695

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  907 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEH 985
Cdd:COG5021    696 VTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDS 774

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  986 PTIKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKET 1058
Cdd:COG5021    775 PIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEK 854

                          410
                   ....*....|....*...
gi 1622962965 1059 LRSKLIQAIDHNEGFSLI 1076
Cdd:COG5021    855 LRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-315 4.22e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 221.00  E-value: 4.22e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   38 NIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLlGSEECIRVPsclpkimcvdsvVRICSGLSygrirnikslsdiQII 117
Cdd:COG5184     99 GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTP------------VQVDAGLS-------------GVV 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  118 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFG 197
Cdd:COG5184    153 AIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  198 QLGLNDENDRYVPNLLKSLrsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIA 277
Cdd:COG5184    230 QLGDGTTTDRATPVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVA 305

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1622962965  278 CGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 315
Cdd:COG5184    306 AGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
185-234 2.82e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 73.71  E-value: 2.82e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622962965  185 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 234
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 728-1074 2.39e-145

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 438.92  E-value: 2.39e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  728 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 806
Cdd:cd00078      1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  807 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 883
Cdd:cd00078     81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  884 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 962
Cdd:cd00078    159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  963 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPV 1040
Cdd:cd00078    239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1622962965 1041 SHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFS 1074
Cdd:cd00078    319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 754-1073 2.51e-113

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 353.85  E-value: 2.51e-113
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   754 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSD----LFHLIGVICGLAIYNFT 829
Cdd:smart00119    4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEehlsYFRFIGRVLGKALYDNR 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   830 IVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQL-LDYPEDDIEEtfcLNFTITVEN-FGATEVKELVLNGADTAV 907
Cdd:smart00119   84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSNIPV 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   908 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 987
Cdd:smart00119  161 TEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQT 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   988 IKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQ 1065
Cdd:smart00119  241 IKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLL 320


                    ....*...
gi 1622962965  1066 AIDHNEGF 1073
Cdd:smart00119  321 AINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 778-1076 1.69e-104

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 329.57  E-value: 1.69e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  778 LLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFED-----SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKKKPSLD 851
Cdd:pfam00632    1 TLLSKELFDPNYGLFEYeTEDDRTYWFNPSSSESpdlelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  852 DLKELMPDVGRSMQQLLDYpEDDIEETFCLNFTITVenFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASL 931
Cdd:pfam00632   81 DLESIDPELYKSLKSLLNM-DNDDDEDLGLTFTIPV--FGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQ 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  932 FDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKQQFLLFLT 1011
Cdd:pfam00632  158 LEAFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVT 237

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622962965 1012 GSDRIPILGMKSL-KLVIQSTGG-GEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSLI 1076
Cdd:pfam00632  238 GSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
679-1076 1.98e-90

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 309.39  E-value: 1.98e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  679 TYPFVFDAQAKTTLLQTD-----AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKN 750
Cdd:COG5021    458 LYRFYFVEHRKKTLTKNDsrlgsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESG 537

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  751 IDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIW----FSDKTFEDSDLFHLIGVICGLAIY 826
Cdd:COG5021    538 DDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIY 617

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  827 NFTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNFTITVENFGATEVKELVLNGADTA 906
Cdd:COG5021    618 DSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNIS 695

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  907 VNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEH 985
Cdd:COG5021    696 VTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDS 774

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  986 PTIKIFWEVFHELPLEKKQQFLLFLTGSDRIPILGMKSL-------KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTDKET 1058
Cdd:COG5021    775 PIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEK 854

                          410
                   ....*....|....*...
gi 1622962965 1059 LRSKLIQAIDHNEGFSLI 1076
Cdd:COG5021    855 LRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-315 4.22e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 221.00  E-value: 4.22e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   38 NIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLlGSEECIRVPsclpkimcvdsvVRICSGLSygrirnikslsdiQII 117
Cdd:COG5184     99 GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTP------------VQVDAGLS-------------GVV 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  118 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFG 197
Cdd:COG5184    153 AIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTT-TDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSG 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  198 QLGLNDENDRYVPNLLKSLrsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIA 277
Cdd:COG5184    230 QLGDGTTTDRATPVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVA 305

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1622962965  278 CGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 315
Cdd:COG5184    306 AGSSHTCA-LLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 38-320 4.61e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 220.62  E-value: 4.61e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   38 NIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGlLGSEECIRVPsclpkimcvdsvVRIcSGLSYgrirnikslsdiqII 117
Cdd:COG5184     49 NVVAVAAGGDHTCALKADGTVWCWGNNSYGQLG-DGTTTDRTTP------------VKV-PGLTG-------------VV 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  118 QVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGiPFMQVAAGGAHSFVLTLSGAIFGWGRNKFG 197
Cdd:COG5184    102 AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTT-TNRLTPVQVDAGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYG 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  198 QLGLNDENDRYVPNLLKSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIA 277
Cdd:COG5184    180 QLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIA 255

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1622962965  278 CGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 320
Cdd:COG5184    256 AGGSHTCA-LKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 40-320 1.60e-61

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 213.69  E-value: 1.60e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   40 VAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLlGSEECIRVPsclpkimcvdsvVRIcSGLSygrirnikslsdiQIIQV 119
Cdd:COG5184      1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGD-GTTTDRSTP------------VRV-PGLS-------------NVVAV 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  120 ACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGipFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL 199
Cdd:COG5184     54 AAGGDHTCALKADGTVWCWGNNSYGQLGDGTT-TDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQL 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  200 GLNDENDRYVPNLLkSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACG 279
Cdd:COG5184    131 GDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAG 207

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1622962965  280 RQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 320
Cdd:COG5184    208 GDHSCA-LKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG 247
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 32-262 3.17e-47

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 172.47  E-value: 3.17e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965   32 VALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGlLGSEECIRVPsclpkimcvdsvvricsglsygriRNIKSL 111
Cdd:COG5184    144 VDAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLG-DGTTTDRPTP------------------------VQVGGL 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962965  112 SDiqIIQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGW 191
Cdd:COG5184    199 SG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTT-TDRATPVQVAGLTGV--VAIAAGGSHTCALKSDGTVWCW 273

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622962965  192 GRNKFGQLGLNDENDRYVPNLLKSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINP 262
Cdd:COG5184    274 GDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
185-234 2.82e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 73.71  E-value: 2.82e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622962965  185 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 234
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
134-182 9.45e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 9.45e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1622962965  134 EVFCWGQNKYGQLGLGTDcKKQTSPQLIKSLLGIPFMQVAAGGAHSFVL 182
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
237-285 1.73e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 65.62  E-value: 1.73e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1622962965  237 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSA 285
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
55-129 7.84e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 57.91  E-value: 7.84e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622962965   55 KGQVYAWGLDSDGQLGLlGSEECIRVPSClpkimcvdsvvricsglsygrirnIKSLSDIQIIQVACGYYHSLAL 129
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGL-GTTENVLVPQK------------------------VEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
116-145 1.61e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.97  E-value: 1.61e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622962965  116 IIQVACGYYHSLALSKASEVFCWGQNKYGQ 145
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
39-68 2.51e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 50.50  E-value: 2.51e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622962965   39 IVAVSCGEAHTLALNDKGQVYAWGLDSDGQ 68
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
171-198 1.29e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.49  E-value: 1.29e-06
                           10        20
                   ....*....|....*....|....*...
gi 1622962965  171 QVAAGGAHSFVLTLSGAIFGWGRNKFGQ 198
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
290-320 1.06e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.66  E-value: 1.06e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622962965  290 SGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 320
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG 31
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
221-250 1.17e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 1.17e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622962965  221 IVYICCGEDHTAALTKEGGVFTFGAGGYGQ 250
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
273-303 4.99e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.17  E-value: 4.99e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622962965  273 VTQIACGRQHTsAFVPSSGRIYSFGLGGNGQ 303
Cdd:pfam13540    1 VVSVAAGDNHT-LALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH