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    FRU FER-like regulator of iron uptake [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817362, updated on 18-Sep-2024

    Summary

    Official Symbol
    FRU
    Official Full Name
    FER-like regulator of iron uptake
    Primary source
    TAIR:AT2G28160
    Locus tag
    AT2G28160
    See related
    Araport:AT2G28160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS FE-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1; ATBHLH029; ATBHLH29; ATFIT1; BASIC HELIX-LOOP-HELIX PROTEIN 29; BHLH029; F24D13.5; F24D13_5; FE-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1; FER-like regulator of iron uptake; FIT1
    Summary
    Encodes a putative transcription factor that regulates iron uptake responses. mRNA is detected in the outer cell layers of the root and accumulates in response to iron deficiency. The expression of many iron-regulated genes is dependent on FIT1. It specifically regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation.Similar to FER in tomato and is a regulator of iron uptake. It is post-transcriptionally controlled.
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    Genomic context

    See FRU in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (12004658..12006276)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene enabled-like protein (DUF1635) Neighboring gene UPSTREAM OF FLC protein (DUF966) Neighboring gene Cation/hydrogen exchanger family protein Neighboring gene ncRNA Neighboring gene cation/hydrogen exchanger family protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    NM_001336147.1
    NM_179783.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity PubMed 
    enables protein binding PubMed 
    enables protein dimerization activity  
    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    FER-like regulator of iron uptake
    NP_850114.1
    • FER-like regulator of iron uptake (FRU); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of iron ion transport, response to cytokinin stimulus, response to iron ion, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT2G16910.1); Has 2366 Blast hits to 2362 proteins in 114 species: Archae - 2; Bacteria - 0; Metazoa - 3; Fungi - 9; Plants - 2350; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12004658..12006276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179783.2 → NP_850114.1  FER-like regulator of iron uptake [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0V7X4, Q8S3E9, Q9ZUV8
      UniProtKB/TrEMBL
      A0A178VTK6, A0A5S9X263, C0SV65
      Conserved Domains (1) summary
      cd11450
      Location:126 → 201
      bHLH_AtFIT_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana Fe-deficiency induced transcription factor 1 (FIT) and similar proteins
    2. NM_001336147.1 → NP_001323907.1  FER-like regulator of iron uptake [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VTK6, A0A1P8AYH9
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