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    kek1 kekkon 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34688, updated on 9-Dec-2024

    Summary

    Official Symbol
    kek1provided by FlyBase
    Official Full Name
    kekkon 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015399
    Locus tag
    Dmel_CG12283
    See related
    AllianceGenome:FB:FBgn0015399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GM02380; CG12283; CT18186; Dmel\CG12283; Dmkek1; GM02380; kek; Kek; kek-1; Kek-1; Kek1; KEK1; kekon; l(2)01433; n(2)k07332; NB1; SD01674; uns
    Summary
    Enables epidermal growth factor receptor binding activity and signaling receptor inhibitor activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and oogenesis. Located in apical plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; follicle cell; imaginal disc; larval midline neurons; and peripheral nervous system. Orthologous to human LRRC24 (leucine rich repeat containing 24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See kek1 in Genome Data Viewer
    Location:
    34A1-34A1; 2-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12817000..12822787, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12817000..12822787, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long noncoding RNA: testis-specific 9 Neighboring gene long non-coding RNA:CR43818 Neighboring gene long non-coding RNA:CR44970 Neighboring gene long non-coding RNA:CR44971

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    kekkon 1
    Names
    CG12283-PB
    CG12283-PC
    Kekkon1
    Kekon-1
    kek1-PB
    kek1-PC
    kekkon
    kekkon-1
    kekkonI
    unstrung

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12817000..12822787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078835.3 → NP_523559.3  kekkon 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523559.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7XBB4, P91643, Q9VK54
      Conserved Domains (6) summary
      cd00096
      Location:346 → 426
      Ig; Immunoglobulin domain
      smart00082
      Location:277 → 327
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:338 → 429
      IG_like; Immunoglobulin like
      cd00116
      Location:119 → 277
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:103 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat
    2. NM_001316391.1 → NP_001303320.1  kekkon 1, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      L7XBB4, P91643, Q9VK54
      Conserved Domains (6) summary
      cd00096
      Location:346 → 426
      Ig; Immunoglobulin domain
      smart00082
      Location:277 → 327
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:338 → 429
      IG_like; Immunoglobulin like
      cd00116
      Location:119 → 277
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:103 → 122
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:148 → 207
      LRR_8; Leucine rich repeat
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