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kek6 kekkon 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43729, updated on 9-Dec-2024

Summary

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Official Symbol
kek6provided by FlyBase
Official Full Name
kekkon 6provided by FlyBase
Primary source
FLYBASE:FBgn0039862
Locus tag
Dmel_CG1804
See related
AllianceGenome:FB:FBgn0039862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1804; Dmel\CG1804; kek-6; Kek-6; Kek6
Summary
Enables neurotrophin binding activity and neurotrophin receptor activity. Involved in regulation of synaptic plasticity. Located in type I terminal bouton. Is expressed in adult head; larval central nervous system; larval ventral nerve cord; and lineage NB3-1 primary motor neurons. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See kek6 in Genome Data Viewer
Location:
100D1-100D1; 3-102 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31622136..31664646)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27447858..27490368)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Medea Neighboring gene microtubule-associated Nat9 Neighboring gene uncharacterized protein Neighboring gene partner of drosha Neighboring gene Zinc finger MYND-type containing 8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
  2. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
  3. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article
  4. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article
  5. Bioinformatic analysis suggests potential mechanisms underlying parasitoid venom evolution and function. Alvarado G, et al. Genomics, 2020 Mar. PMID 31247332

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neurotrophin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neurotrophin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in type I terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kekkon 6
Names
CG1804-PA
CG1804-PB
kek6-PA
kek6-PB
kekkon-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31622136..31664646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143623.2 → NP_651880.1  kekkon 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651880.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9V6
    Related
    FBpp0085182
    Conserved Domains (5) summary
    cd00096
    Location:295 → 367
    Ig; Immunoglobulin domain
    smart00082
    Location:225 → 274
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:71 → 96
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:144 → 186
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:96 → 155
    LRR_8; Leucine rich repeat

  2. NM_001276222.1 → NP_001263151.1  kekkon 6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263151.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHL5
    Conserved Domains (5) summary
    cd00096
    Location:295 → 367
    Ig; Immunoglobulin domain
    smart00082
    Location:225 → 274
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:71 → 96
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:144 → 186
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:96 → 155
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHL5 A0A0B4KHL5
Q9V9V6 Q9V9V6

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