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    Traf6 TNF receptor-associated factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 22034, updated on 9-Dec-2024

    Summary

    Official Symbol
    Traf6provided by MGI
    Official Full Name
    TNF receptor-associated factor 6provided by MGI
    Primary source
    MGI:MGI:108072
    See related
    Ensembl:ENSMUSG00000027164 AllianceGenome:MGI:108072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310003F17Rik; C630032O20Rik
    Summary
    This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.0), thymus adult (RPKM 2.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Traf6 in Genome Data Viewer
    Location:
    2 E2; 2 53.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (101508765..101532013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (101678420..101701668)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene recombination activating 1 Neighboring gene predicted gene, 34041 Neighboring gene STARR-positive B cell enhancer ABC_E5948 Neighboring gene STARR-positive B cell enhancer ABC_E5949 Neighboring gene proline rich 5 like Neighboring gene STARR-seq mESC enhancer starr_05236 Neighboring gene STARR-seq mESC enhancer starr_05237 Neighboring gene STARR-positive B cell enhancer ABC_E2043 Neighboring gene COMM domain containing 9

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein kinase B binding  
    enables protein kinase B binding  
    enables protein-macromolecule adaptor activity  
    enables signaling adaptor activity  
    enables tumor necrosis factor receptor binding  
    enables ubiquitin conjugating enzyme binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    enables ubiquitin protein ligase activity PubMed 
    enables ubiquitin protein ligase activity PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity PubMed 
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-ubiquitin ligase activity  
    enables ubiquitin-ubiquitin ligase activity  
    enables zinc ion binding  
    Items 1 - 25 of 93
    Process Evidence Code Pubs
    involved_in CD40 signaling pathway  
    involved_in DNA damage response  
    involved_in JNK cascade  
    involved_in T cell receptor signaling pathway  
    involved_in T cell receptor signaling pathway  
    acts_upstream_of_or_within T-helper 1 type immune response PubMed 
    involved_in activation of protein kinase activity  
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II PubMed 
    involved_in antiviral innate immune response  
    involved_in antiviral innate immune response  
    involved_in autophagosome assembly  
    involved_in autophagosome assembly  
    involved_in bone remodeling PubMed 
    involved_in bone resorption PubMed 
    involved_in canonical NF-kappaB signal transduction PubMed 
    involved_in canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within cell development PubMed 
    involved_in cellular response to cytokine stimulus  
    acts_upstream_of_or_within cellular response to lipopolysaccharide PubMed 
    involved_in cytokine-mediated signaling pathway  
    involved_in cytoplasmic pattern recognition receptor signaling pathway  
    involved_in cytoplasmic pattern recognition receptor signaling pathway  
    acts_upstream_of_or_within immune response PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in innate immune response  
    involved_in interleukin-1-mediated signaling pathway PubMed 
    involved_in interleukin-1-mediated signaling pathway  
    involved_in interleukin-17-mediated signaling pathway PubMed 
    involved_in interleukin-17-mediated signaling pathway PubMed 
    involved_in interleukin-17A-mediated signaling pathway  
    involved_in interleukin-17A-mediated signaling pathway  
    involved_in interleukin-33-mediated signaling pathway  
    involved_in interleukin-33-mediated signaling pathway  
    involved_in lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within myeloid dendritic cell differentiation PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neural tube closure PubMed 
    involved_in non-canonical NF-kappaB signal transduction  
    involved_in non-canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within ossification PubMed 
    involved_in osteoclast differentiation PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of JUN kinase activity  
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of T cell cytokine production  
    involved_in positive regulation of T cell cytokine production  
    involved_in positive regulation of T cell proliferation PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of interleukin-12 production PubMed 
    involved_in positive regulation of interleukin-2 production  
    involved_in positive regulation of interleukin-2 production  
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway PubMed 
    involved_in positive regulation of osteoclast differentiation  
    involved_in positive regulation of osteoclast differentiation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription regulatory region DNA binding  
    involved_in positive regulation of type I interferon production PubMed 
    involved_in protein K63-linked ubiquitination PubMed 
    involved_in protein K63-linked ubiquitination  
    acts_upstream_of_or_within protein autoubiquitination PubMed 
    involved_in protein autoubiquitination  
    involved_in protein autoubiquitination PubMed 
    involved_in protein branched polyubiquitination  
    involved_in protein polyubiquitination PubMed 
    involved_in protein polyubiquitination  
    acts_upstream_of_or_within protein ubiquitination PubMed 
    acts_upstream_of_or_within protein ubiquitination PubMed 
    involved_in regulation of apoptotic process  
    involved_in regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within regulation of immunoglobulin production PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
    involved_in response to interleukin-1  
    acts_upstream_of_or_within signal transduction PubMed 
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor 4 signaling pathway  
    Items 1 - 25 of 93
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    part_of CD40 receptor complex PubMed 
    located_in cell cortex  
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in extrinsic component of cytoplasmic side of plasma membrane  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in lipid droplet PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    part_of plasma membrane signaling receptor complex  
    part_of protein-containing complex PubMed 
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    TNF receptor-associated factor 6
    Names
    E3 ubiquitin-protein ligase TRAF6
    RING-type E3 ubiquitin transferase TRAF6
    NP_001290202.1
    NP_033450.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303273.1NP_001290202.1  TNF receptor-associated factor 6

      See identical proteins and their annotated locations for NP_001290202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL929571
      Consensus CDS
      CCDS16464.1
      UniProtKB/Swiss-Prot
      P70196, Q6P9M0, Q8BLV2
      Conserved Domains (4) summary
      cd00162
      Location:69107
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03776
      Location:359508
      MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...
      pfam02176
      Location:204261
      zf-TRAF; TRAF-type zinc finger
      cl01090
      Location:304356
      SlyX; SlyX
    2. NM_009424.3NP_033450.2  TNF receptor-associated factor 6

      See identical proteins and their annotated locations for NP_033450.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL929571, BC060705, BY131535
      Consensus CDS
      CCDS16464.1
      UniProtKB/Swiss-Prot
      P70196, Q6P9M0, Q8BLV2
      Related
      ENSMUSP00000004949.8, ENSMUST00000004949.8
      Conserved Domains (4) summary
      cd00162
      Location:69107
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd03776
      Location:359508
      MATH_TRAF6; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter ...
      pfam02176
      Location:204261
      zf-TRAF; TRAF-type zinc finger
      cl01090
      Location:304356
      SlyX; SlyX

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      101508765..101532013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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