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Aldoa aldolase A, fructose-bisphosphate [ Mus musculus (house mouse) ]

Gene ID: 11674, updated on 27-Nov-2024

Summary

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Official Symbol
Aldoaprovided by MGI
Official Full Name
aldolase A, fructose-bisphosphateprovided by MGI
Primary source
MGI:MGI:87994
See related
Ensembl:ENSMUSG00000030695 AllianceGenome:MGI:87994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aldo1; Aldo-1
Summary
Enables fructose-bisphosphate aldolase activity and protease binding activity. Involved in canonical glycolysis and positive regulation of cell migration. Located in Z disc; plasma membrane; and sperm fibrous sheath. Part of protein-containing complex. Is active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 794.0), subcutaneous fat pad adult (RPKM 494.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Aldoa in Genome Data Viewer
Location:
7 F3; 7 69.25 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126394406..126399537, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126795234..126800994, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene T-box 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E6603 Neighboring gene predicted gene, 57854 Neighboring gene STARR-positive B cell enhancer ABC_E10476 Neighboring gene TLC domain containing 3B Neighboring gene RIKEN cDNA 4930451I11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Negative regulation of the mouse aldolase A gene. A cell cycle-dependent DNA binding activity functions as a silencer of gene transcription. Lupo A, et al. J Biol Chem, 1997 Dec 12. PMID 9395505
  2. Sequence of a mouse brain aldolase A cDNA. Mestek A, et al. Nucleic Acids Res, 1987 Dec 23. PMID 3697100, Free PMC Article
  3. The proximal promoter of the aldolase A gene remains active during myogenesis in vitro and muscle development in vivo. Colbert MC, et al. Dev Biol, 1992 Jan. PMID 1728594
  4. Nonconservative utilization of aldolase A alternative promoters. Stauffer JK, et al. J Biol Chem, 1990 Jul 15. PMID 2365699
  5. Integrating Proteomics and Enzyme Kinetics Reveals Tissue-Specific Types of the Glycolytic and Gluconeogenic Pathways. Wiśniewski JR, et al. J Proteome Res, 2015 Aug 7. PMID 26080680

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.
    Title: Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.
  2. The results presented here point to ALDA as a factor involved in the regulation of cells proliferation.
    Title: Nuclear localization of aldolase A correlates with cell proliferation.
  3. Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
    Title: Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107164, AC124505.11

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables fructose binding ISO
Inferred from Sequence Orthology
more info
  
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose-bisphosphate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fructose-bisphosphate aldolase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables fructose-bisphosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
  
enables fructose-bisphosphate aldolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in canonical glycolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 1,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fructose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glycolytic process through fructose-6-phosphate IC
Inferred by Curator
more info
 PubMed 
involved_in methylglyoxal biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in striated muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in M band IEA
Inferred from Electronic Annotation
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space HDA PubMed 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm head ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fructose-bisphosphate aldolase A
Names
muscle-type aldolase
NP_001170778.1
NP_001170779.1
NP_001398830.1
NP_001398831.1
NP_001398832.1
NP_001398833.1
NP_031464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177307.2 → NP_001170778.1  fructose-bisphosphate aldolase A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001170778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS52399.1
    UniProtKB/TrEMBL
    A6ZI44, Q6NY00
    Related
    ENSMUSP00000084846.5, ENSMUST00000087566.11
    Conserved Domains (1) summary
    pfam00274
    Location:69 → 418
    Glycolytic; Fructose-bisphosphate aldolase class-I

  2. NM_001177308.2 → NP_001170779.1  fructose-bisphosphate aldolase A isoform 2

    See identical proteins and their annotated locations for NP_001170779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in its 5' end and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21845.1
    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7, Q6NY00
    Related
    ENSMUSP00000101955.2, ENSMUST00000106348.8
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

  3. NM_001411901.1 → NP_001398830.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/TrEMBL
    A6ZI44

  4. NM_001411902.1 → NP_001398831.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/TrEMBL
    A6ZI44

  5. NM_001411903.1 → NP_001398832.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/TrEMBL
    A6ZI44

  6. NM_001411904.1 → NP_001398833.1  fructose-bisphosphate aldolase A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7

  7. NM_007438.5 → NP_031464.1  fructose-bisphosphate aldolase A isoform 2

    See identical proteins and their annotated locations for NP_031464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21845.1
    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7, Q6NY00
    Related
    ENSMUSP00000032934.6, ENSMUST00000032934.12
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126394406..126399537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05064.2 GenPept UniProtKB/Swiss-Prot:P05064

Gene LinkOut

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