Bid BH3 interacting domain death agonist [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bidprovided by MGI
Official Full Name: BH3 interacting domain death agonistprovided by MGI
Primary source: MGI:MGI:108093
See related: Ensembl:ENSMUSG00000004446 AllianceGenome:MGI:108093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700049M22Rik
Summary: Enables ubiquitin protein ligase binding activity. Involved in positive regulation of cellular component organization; protein-containing complex assembly; and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; hepatocyte apoptotic process; and regulation of apoptotic process. Located in cytosol and mitochondrial membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human BID (BH3 interacting domain death agonist). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 20.6), thymus adult (RPKM 10.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 57.02 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (120870080..120894074, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (120893119..120917062, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK.
Title: The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK.
Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes.
Title: Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes.
Plants expressing murine pro-apoptotic protein Bid do not have enhanced PCD.
Title: Plants expressing murine pro-apoptotic protein Bid do not have enhanced PCD.
Bid monomers lie shallowly on the lipid bilayer, where they self-assemble to form oligomers. During the initiation phase of self-assembly, the two central hydrophobic helices (alpha6 and alpha7) of Bid insert halfway into the phospholipid core, while the other helices remain on the surface.
Title: Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation.
Bid promotes E3 ubiquitin ligase-mediated signaling downstream of TLR3 and TLR4 inducing a pro-inflammatory response.
Title: Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.
These results identify a role for Bid in homeostatic mitochondrial cristae reorganization, that we link to human cardiac disease.
Title: Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.
we show that BID is an important regulator downstream of FAS in mouse neutrophils. Loss of BID significantly delays FASL-cell death and partially counteracts the switch from apoptosis to necroptosis when caspases are blocked.
Title: Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.
Study exposes BID as the molecular link between the previously separated pathways of oxidative stress signaling by merging the death pathways of ferroptosis and oxytosis at the level of mitochondria, i.e. the crucial point of decision for neuronal function and survival.
Title: BID links ferroptosis to mitochondrial cell death pathways.
Cleaved Bid did not permeabilize the membrane, but lowered the membrane breakthrough force.
Title: Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study.
toxic reactive oxygen species levels in Mll5(-/-) mice are critically dependent on type 1 interferon (IFN-1) signaling, which triggers mitochondrial accumulation of full-length Bid.
Title: DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.

Submit: New GeneRIF Correction See all GeneRIFs (115)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU022477 (e-PCR)
- UniSTS:159565

AI875481 (e-PCR)
- UniSTS:165485

Bid (e-PCR), detects polymorphism
- UniSTS:141176

Bid (e-PCR), detects polymorphism
- UniSTS:141177

AU022477 (e-PCR)
- UniSTS:208023

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrial outer membrane permeabilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy in response to ER overload	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in signal transduction in response to DNA damage	TAS Traceable Author Statement more info	PubMed
involved_in supramolecular fiber organization	IEA Inferred from Electronic Annotation more info
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BH3-interacting domain death agonist

Names: p22 BID

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.