Gripap1 GRIP1 associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gripap1provided by MGI
Official Full Name: GRIP1 associated protein 1provided by MGI
Primary source: MGI:MGI:1859616
See related: Ensembl:ENSMUSG00000031153 AllianceGenome:MGI:1859616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sfc10; GRASP-1; DXImx47e; mKIAA1167
Summary: Predicted to enable guanyl-nucleotide exchange factor activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in heart; lung; nervous system; and sensory organ. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 16.9), cerebellum adult (RPKM 16.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.51 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7656009..7686805)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7789961..7820567)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of synaptic structure	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of modification of synaptic structure	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of recycling endosome localization within postsynapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of recycling endosome localization within postsynapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of postsynaptic early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extrinsic component of postsynaptic early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GRIP1-associated protein 1

Names: HCMV-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290455.2 → NP_001277384.1 GRIP1-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_001277384.1

Status: VALIDATED

Source sequence(s)

AL671995

Consensus CDS

CCDS72334.1

UniProtKB/TrEMBL

A2AEW8

Related

ENSMUSP00000111339.3, ENSMUST00000115675.9

Conserved Domains (1) summary

pfam07888
Location:2 → 290

CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
NM_001359289.2 → NP_001346218.1 GRIP1-associated protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL671995

Related

ENSMUST00000132456.8

Conserved Domains (1) summary

cl25732
Location:215 → 560

SMC_N; RecF/RecN/SMC N terminal domain
NM_001359290.2 → NP_001346219.1 GRIP1-associated protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL671995

Conserved Domains (2) summary

cl25732
Location:193 → 480

SMC_N; RecF/RecN/SMC N terminal domain

cl26511
Location:235 → 732

Neuromodulin_N; Gap junction protein N-terminal region
NM_001359291.2 → NP_001346220.1 GRIP1-associated protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL671995

Conserved Domains (1) summary

cl25732
Location:260 → 602

SMC_N; RecF/RecN/SMC N terminal domain
NM_001359293.2 → NP_001346222.1 GRIP1-associated protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL671995

Consensus CDS

CCDS90694.1

UniProtKB/TrEMBL

A2AEW9

Related

ENSMUSP00000099218.4, ENSMUST00000101694.10

Conserved Domains (2) summary

TIGR04211
Location:7 → 108

SH3_and_anchor; SH3 domain protein

cl25732
Location:170 → 540

SMC_N; RecF/RecN/SMC N terminal domain
NM_001426310.1 → NP_001413239.1 GRIP1-associated protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426311.1 → NP_001413240.1 GRIP1-associated protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426312.1 → NP_001413241.1 GRIP1-associated protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426313.1 → NP_001413242.1 GRIP1-associated protein 1 isoform 10

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426314.1 → NP_001413243.1 GRIP1-associated protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426315.1 → NP_001413244.1 GRIP1-associated protein 1 isoform 12

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426316.1 → NP_001413245.1 GRIP1-associated protein 1 isoform 13

Status: VALIDATED

Source sequence(s)

AL671995
NM_001426317.1 → NP_001413246.1 GRIP1-associated protein 1 isoform 14

Status: VALIDATED

Source sequence(s)

AL671995
NM_207670.3 → NP_997553.1 GRIP1-associated protein 1 isoform 2

See identical proteins and their annotated locations for NP_997553.1

Status: VALIDATED

Source sequence(s)

AL671995

Consensus CDS

CCDS40844.1

UniProtKB/Swiss-Prot

A2AEW7, O35693, Q3T9C3, Q69ZP9, Q8VD04

Related

ENSMUSP00000068789.8, ENSMUST00000065932.14

Conserved Domains (2) summary

PLN00181
Location:518 → 708

PLN00181; protein SPA1-RELATED; Provisional

TIGR02168
Location:260 → 602

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

7656009..7686805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527671.5 → XP_006527734.1 GRIP1-associated protein 1 isoform X3

Conserved Domains (2) summary

COG1196
Location:215 → 585

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:7 → 414

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036162029.1 → XP_036017922.1 GRIP1-associated protein 1 isoform X7

Conserved Domains (2) summary

COG1196
Location:193 → 480

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:38 → 621

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036162030.1 → XP_036017923.1 GRIP1-associated protein 1 isoform X13

Conserved Domains (2) summary

COG1196
Location:26 → 365

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:244 → 586

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006527673.5 → XP_006527736.1 GRIP1-associated protein 1 isoform X5

Conserved Domains (1) summary

TIGR02168
Location:9 → 622

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006527680.5 → XP_006527743.1 GRIP1-associated protein 1 isoform X11

Conserved Domains (2) summary

COG0419
Location:142 → 598

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

TIGR04211
Location:7 → 108

SH3_and_anchor; SH3 domain protein
XM_006527681.5 → XP_006527744.1 GRIP1-associated protein 1 isoform X18

Conserved Domains (1) summary

COG1196
Location:170 → 515

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_030251402.2 → XP_030107262.1 GRIP1-associated protein 1 isoform X16

Conserved Domains (2) summary

COG1196
Location:148 → 435

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:2 → 678

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006527683.5 → XP_006527746.1 GRIP1-associated protein 1 isoform X22

Conserved Domains (3) summary

PLN00181
Location:457 → 647

PLN00181; protein SPA1-RELATED; Provisional

COG1196
Location:3 → 320

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:199 → 541

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_017318565.2 → XP_017174054.1 GRIP1-associated protein 1 isoform X8

Conserved Domains (2) summary

COG1196
Location:231 → 601

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:54 → 405

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_017318566.2 → XP_017174055.1 GRIP1-associated protein 1 isoform X15

Conserved Domains (1) summary

TIGR02168
Location:276 → 618

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006527669.5 → XP_006527732.1 GRIP1-associated protein 1 isoform X1

Conserved Domains (1) summary

COG1196
Location:231 → 601

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_017318570.1 → XP_017174059.1 GRIP1-associated protein 1 isoform X20

Conserved Domains (2) summary

COG1196
Location:231 → 601

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:54 → 405

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006527674.5 → XP_006527737.1 GRIP1-associated protein 1 isoform X6

Conserved Domains (2) summary

COG1196
Location:231 → 576

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:53 → 402

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006527672.5 → XP_006527735.1 GRIP1-associated protein 1 isoform X4

Conserved Domains (2) summary

COG1196
Location:209 → 496

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:54 → 637

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_030251399.2 → XP_030107259.1 GRIP1-associated protein 1 isoform X10

Conserved Domains (1) summary

TIGR02168
Location:260 → 602

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006527670.3 → XP_006527733.1 GRIP1-associated protein 1 isoform X2

Conserved Domains (1) summary

COG0419
Location:194 → 650

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_006527676.3 → XP_006527739.1 GRIP1-associated protein 1 isoform X9

Conserved Domains (1) summary

COG0419
Location:158 → 614

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
XM_030251400.1 → XP_030107260.1 GRIP1-associated protein 1 isoform X12

Conserved Domains (1) summary

COG1196
Location:164 → 451

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_006527684.2 → XP_006527747.1 GRIP1-associated protein 1 isoform X25

Conserved Domains (1) summary

COG1196
Location:68 → 438

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_036162032.1 → XP_036017925.1 GRIP1-associated protein 1 isoform X25

Conserved Domains (1) summary

COG1196
Location:68 → 438

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]