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    Egfr epidermal growth factor receptor [ Mus musculus (house mouse) ]

    Gene ID: 13649, updated on 13-Jan-2025

    Summary

    Official Symbol
    Egfrprovided by MGI
    Official Full Name
    epidermal growth factor receptorprovided by MGI
    Primary source
    MGI:MGI:95294
    See related
    Ensembl:ENSMUSG00000020122 AllianceGenome:MGI:95294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wa5; wa2; Erbb; Errp; wa-2; Errb1; 9030024J15Rik
    Summary
    Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in several processes, including ERBB2-EGFR signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including eyelid development in camera-type eye; hair follicle development; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in liver adult (RPKM 26.7), liver E18 (RPKM 8.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Egfr in Genome Data Viewer
    Location:
    11 A2; 11 9.41 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16700153..16868158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16752203..16913907)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12664 Neighboring gene predicted gene, 39583 Neighboring gene STARR-positive B cell enhancer mm9_chr11:16641095-16641396 Neighboring gene predicted gene, 25698 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene F-box protein 48 Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene pleckstrin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 58
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables actin filament binding  
    enables actin filament binding  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables calmodulin binding  
    enables calmodulin binding  
    enables chromatin binding  
    enables chromatin binding  
    enables enzyme binding  
    enables epidermal growth factor binding  
    enables epidermal growth factor binding PubMed 
    enables epidermal growth factor binding  
    enables epidermal growth factor receptor activity PubMed 
    enables epidermal growth factor receptor activity PubMed 
    enables epidermal growth factor receptor activity PubMed 
    contributes_to epidermal growth factor receptor activity  
    enables epidermal growth factor receptor activity PubMed 
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables integrin binding  
    enables integrin binding  
    enables kinase activity PubMed 
    enables kinase binding  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding  
    enables signaling receptor binding  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane signaling receptor activity  
    enables transmembrane-ephrin receptor activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 58
    Items 1 - 25 of 164
    Process Evidence Code Pubs
    involved_in ERBB2-EGFR signaling pathway PubMed 
    involved_in ERBB2-EGFR signaling pathway PubMed 
    involved_in ERBB2-EGFR signaling pathway PubMed 
    involved_in Kit signaling pathway  
    involved_in astrocyte activation  
    involved_in astrocyte activation  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within cell surface receptor signaling pathway  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion  
    involved_in cellular response to amino acid stimulus PubMed 
    involved_in cellular response to cadmium ion  
    involved_in cellular response to dexamethasone stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to estradiol stimulus  
    involved_in cellular response to estradiol stimulus  
    acts_upstream_of_or_within cellular response to growth factor stimulus PubMed 
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to xenobiotic stimulus  
    acts_upstream_of_or_within cerebral cortex cell migration PubMed 
    involved_in chromatin remodeling  
    involved_in circadian rhythm  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    acts_upstream_of_or_within digestive tract morphogenesis PubMed 
    involved_in diterpenoid metabolic process  
    acts_upstream_of_or_within embryonic placenta development PubMed 
    involved_in ephrin receptor signaling pathway  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within epidermis development PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within eyelid development in camera-type eye PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within hair follicle development PubMed 
    acts_upstream_of_or_within hair follicle development PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in hydrogen peroxide metabolic process  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in learning or memory  
    involved_in learning or memory  
    involved_in liver regeneration  
    involved_in liver regeneration  
    involved_in lung development  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in midgut development  
    acts_upstream_of_or_within morphogenesis of an epithelial fold PubMed 
    involved_in multicellular organism development  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cardiocyte differentiation  
    involved_in negative regulation of cardiocyte differentiation  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of mitotic cell cycle  
    involved_in negative regulation of mitotic cell cycle  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of protein catabolic process  
    involved_in neurogenesis  
    involved_in neuron projection morphogenesis  
    involved_in neuron projection morphogenesis  
    involved_in ovulation cycle  
    involved_in ovulation cycle  
    involved_in peptidyl-tyrosine autophosphorylation  
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of DNA replication  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of bone resorption  
    involved_in positive regulation of bone resorption  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of epithelial cell proliferation  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of fibroblast proliferation PubMed 
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of mucus secretion  
    involved_in positive regulation of mucus secretion  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of prolactin secretion  
    involved_in positive regulation of prolactin secretion  
    involved_in positive regulation of protein kinase C activity  
    involved_in positive regulation of protein localization to early endosome  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of superoxide anion generation  
    involved_in positive regulation of superoxide anion generation  
    involved_in positive regulation of synaptic transmission, glutamatergic  
    involved_in positive regulation of synaptic transmission, glutamatergic  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vasoconstriction  
    involved_in positive regulation of vasoconstriction  
    acts_upstream_of_or_within protein autophosphorylation PubMed 
    involved_in protein autophosphorylation  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of JNK cascade  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in response to UV-A  
    involved_in response to UV-A  
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    involved_in response to cobalamin  
    involved_in response to hydroxyisoflavone  
    involved_in response to oxidative stress  
    acts_upstream_of_or_within salivary gland morphogenesis PubMed 
    acts_upstream_of_or_within signal transduction PubMed 
    involved_in signal transduction  
    involved_in tongue development  
    involved_in translation  
    involved_in translation  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in vasodilation  
    involved_in vasodilation  
    Items 1 - 25 of 164
    Items 1 - 20 of 44
    Component Evidence Code Pubs
    located_in Golgi membrane  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    is_active_in basal plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in cell junction  
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cytoplasm  
    located_in early endosome membrane  
    located_in early endosome membrane  
    located_in endocytic vesicle PubMed 
    located_in endocytic vesicle  
    located_in endoplasmic reticulum membrane  
    colocalizes_with endosome  
    located_in endosome  
    located_in endosome  
    located_in endosome membrane  
    located_in glutamatergic synapse  
    located_in intracellular anatomical structure PubMed 
    located_in intracellular vesicle  
    located_in membrane  
    located_in membrane raft  
    located_in membrane raft  
    located_in multivesicular body, internal vesicle lumen  
    located_in multivesicular body, internal vesicle lumen  
    located_in nuclear membrane  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    is_active_in plasma membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in plasma membrane PubMed 
    is_active_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of receptor complex  
    part_of receptor complex PubMed 
    located_in ruffle membrane  
    is_active_in ruffle membrane  
    located_in synaptic membrane  
    Items 1 - 20 of 44

    General protein information

    Preferred Names
    epidermal growth factor receptor
    Names
    avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
    waved 2
    NP_031938.1
    NP_997538.1
    XP_036012181.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007912.4NP_031938.1  epidermal growth factor receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_031938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK004883, AK004944
      Consensus CDS
      CCDS24444.1
      UniProtKB/TrEMBL
      Q5SVE9, Q9ERV6, Q9WVF5
      Related
      ENSMUSP00000099948.4, ENSMUST00000102884.10
      Conserved Domains (5) summary
      smart00261
      Location:552598
      FU; Furin-like repeats
      cd00064
      Location:231274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:184335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:57168
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:505636
      GF_recep_IV; Growth factor receptor domain IV
    2. NM_207655.2NP_997538.1  epidermal growth factor receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_997538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF275367, AK004883, AK163338, BQ553815, BY725722
      Consensus CDS
      CCDS24443.1
      UniProtKB/Swiss-Prot
      Q01279
      UniProtKB/TrEMBL
      Q9EP98
      Related
      ENSMUSP00000020329.7, ENSMUST00000020329.13
      Conserved Domains (8) summary
      smart00219
      Location:715970
      TyrKc; Tyrosine kinase, catalytic domain
      cd12093
      Location:634679
      TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
      smart00261
      Location:552598
      FU; Furin-like repeats
      cd00064
      Location:231274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05108
      Location:7061018
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:184335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:57168
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:505636
      GF_recep_IV; Growth factor receptor domain IV

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      16700153..16868158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156288.1XP_036012181.1  epidermal growth factor receptor isoform X1

      UniProtKB/TrEMBL
      Q9EP98
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