Dok2 docking protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dok2provided by MGI
Official Full Name: docking protein 2provided by MGI
Primary source: MGI:MGI:1332623
See related: Ensembl:ENSMUSG00000022102 AllianceGenome:MGI:1332623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DokR; Frip; dok-R
Summary: Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within Ras protein signal transduction and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and lung. Orthologous to human DOK2 (docking protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 22.4), mammary gland adult (RPKM 7.3) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.71 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (71003336..71015934)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70765889..70778494)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.
Title: DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.
Introduction to DOK2 and its potential role in cancer.
Title: Introduction to DOK2 and its potential role in cancer.
compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion synergistically activated MAPK signaling and promoted cell proliferation.
Title: Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis.
Title: Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia.
These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8(+) T cells and promotes memory formation.
Title: Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.
Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1.
Title: Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8(+) T Cells in a Murine Model of Ocular Infection.
this study shows that Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation
Title: Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.
Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A and IL-22 expression.
Title: Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.
Dok2 is able to control Klf1 expression by transcriptional regulation through directly binding to its promoter region.
Title: Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells.
DOK2 as a tumor suppressor in EGFR-mutant lung adenocarcinoma
Title: DOK2 inhibits EGFR-mutated lung adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dok2 (e-PCR), detects polymorphism
- UniSTS:142862

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane receptor protein tyrosine kinase adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ras protein signal transduction	IPI Inferred from Physical Interaction more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of MAPK cascade	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: docking protein 2

Names: IL-four receptor-interacting protein; dok-related protein; downstream of tyrosine kinase 2; p56(dok-2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401280.1 → NP_001388209.1 docking protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC125180
NM_001401281.1 → NP_001388210.1 docking protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC125180
NM_010071.3 → NP_034201.1 docking protein 2 isoform 1

See identical proteins and their annotated locations for NP_034201.1

Status: VALIDATED

Source sequence(s)

AC125180

Consensus CDS

CCDS27262.1

UniProtKB/Swiss-Prot

O70272, O70469, Q99KL1

UniProtKB/TrEMBL

Q3TX09, Q3U208

Related

ENSMUSP00000022698.8, ENSMUST00000022698.8

Conserved Domains (3) summary

cd01203
Location:150 → 248

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

cd14676
Location:10 → 117

PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

pfam00169
Location:9 → 113

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

71003336..71015934

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158435.1 → XP_036014328.1 docking protein 2 isoform X3

Conserved Domains (1) summary

cd01203
Location:15 → 113

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
XM_036158437.1 → XP_036014330.1 docking protein 2 isoform X3

Conserved Domains (1) summary

cd01203
Location:15 → 113

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
XM_036158434.1 → XP_036014327.1 docking protein 2 isoform X3

Conserved Domains (1) summary

cd01203
Location:15 → 113

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
XM_036158436.1 → XP_036014329.1 docking protein 2 isoform X3

Conserved Domains (1) summary

cd01203
Location:15 → 113

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
XM_017315834.2 → XP_017171323.1 docking protein 2 isoform X2

Conserved Domains (1) summary

cd01203
Location:51 → 149

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
XM_011244943.4 → XP_011243245.1 docking protein 2 isoform X1

UniProtKB/TrEMBL

Q3U208

Conserved Domains (2) summary

cd01203
Location:172 → 270

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

cl17171
Location:43 → 139

PH-like; Pleckstrin homology-like domain