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    IscU Iron-sulfur cluster assembly enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41059, updated on 27-Dec-2024

    Summary

    Official Symbol
    IscUprovided by FlyBase
    Official Full Name
    Iron-sulfur cluster assembly enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037637
    Locus tag
    Dmel_CG9836
    See related
    AllianceGenome:FB:FBgn0037637
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9836; dIscU; Dmel\CG9836; fIscU; iscu; Iscu; Isu1
    Summary
    Enables ferrous iron binding activity. Involved in iron-sulfur cluster assembly and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and larval muscle system. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See IscU in Genome Data Viewer
    Location:
    85B2-85B2; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8822849..8824177, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4648571..4649899, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43130 Neighboring gene aaquetzalli Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene polychaetoid Neighboring gene transfer RNA:Arginine-TCG 2-3

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding  
    enables ferrous iron binding  
    enables ferrous iron binding PubMed 
    enables iron ion binding  
    enables iron-sulfur cluster binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    part_of mitochondrial [2Fe-2S] assembly complex PubMed 
    is_active_in mitochondrial matrix  
    is_active_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix  

    General protein information

    Preferred Names
    Iron-sulfur cluster assembly enzyme
    Names
    CG9836-PA
    IscU homolog
    IscU homologue
    IscU-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8822849..8824177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141583.4 → NP_649840.1  Iron-sulfur cluster assembly enzyme [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649840.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHK6
      Related
      FBpp0081412
      Conserved Domains (1) summary
      PRK11325
      Location:26 → 150
      PRK11325; scaffold protein; Provisional
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