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Hsc20 Heat shock protein cognate 20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740624, updated on 9-Dec-2024

Summary

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Official Symbol
Hsc20provided by FlyBase
Official Full Name
Heat shock protein cognate 20provided by FlyBase
Primary source
FLYBASE:FBgn0263606
Locus tag
Dmel_CG34246
See related
AllianceGenome:FB:FBgn0263606
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG34246; Dmel\CG34246; l(3)72Do
Summary
Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Involved in iron-sulfur cluster assembly. Is active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Hsc20 in Genome Data Viewer
Location:
72D10-72D10; 3-44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16233127..16234165)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16226227..16227265)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Thioredoxin-related transmembrane protein 3 Neighboring gene Programmed Cell Death 5 Neighboring gene Mediator complex subunit 10 Neighboring gene lethal (3) 72Dp Neighboring gene lethal (3) 72Dr Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. Uhrigshardt H, et al. J Biol Inorg Chem, 2013 Apr. PMID 23444034, Free PMC Article
  2. Temperature-Related Reaction Norms of Gene Expression: Regulatory Architecture and Functional Implications. Chen J, et al. Mol Biol Evol, 2015 Sep. PMID 25976350, Free PMC Article
  3. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article
  4. Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation. Tsakiri EN, et al. Aging Cell, 2019 Feb. PMID 30537423, Free PMC Article
  5. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in [2Fe-2S] cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heat shock protein cognate 20
Names
CG34246-PA
Hsc20-PA
lethal (3) 72Do

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16233127..16234165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104146.3 → NP_001097616.1  heat shock protein cognate 20 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097616.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNT7
    Conserved Domains (3) summary
    cd06257
    Location:75 → 135
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    PRK03578
    Location:75 → 239
    hscB; co-chaperone HscB; Provisional
    pfam07743
    Location:159 → 231
    HSCB_C; HSCB C-terminal oligomerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNT7 A8JNT7

Gene LinkOut

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