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    lev-9 Protein lev-9 [ Caenorhabditis elegans ]

    Gene ID: 188252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lev-9
    Official Full Name
    Protein lev-9
    Primary source
    WormBase:WBGene00002976
    Locus tag
    CELE_T07H6.5
    See related
    AllianceGenome:WB:WBGene00002976
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase inhibitor activity. Located in extracellular space. Is expressed in body wall musculature; intestine; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; IgA glomerulonephritis; atopic dermatitis; cerebrovascular disease (multiple); and coronary artery disease (multiple). Orthologous to several human genes including CR1 (complement C3b/C4b receptor 1 (Knops blood group)); CR1L (complement C3b/C4b receptor 1 like); and C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lev-9 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (6281847..6291732, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene Protein-serine O-palmitoleoyltransferase porcupine

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteolytic processing of the extracellular scaffolding protein LEV-9 is required for clustering acetylcholine receptors. Briseño-Roa L, et al. J Biol Chem, 2014 Apr 18. PMID 24619422, Free PMC Article
    2. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Ishii N, et al. Neuron, 1992 Nov. PMID 1329863
    3. Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains. González-Calvo I, et al. Front Neurosci, 2022. PMID 35546877, Free PMC Article
    4. A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. elegans. Rapti G, et al. EMBO J, 2011 Feb 16. PMID 21252855, Free PMC Article
    5. Long-term nicotine adaptation in Caenorhabditis elegans involves PKC-dependent changes in nicotinic receptor abundance. Waggoner LE, et al. J Neurosci, 2000 Dec 1. PMID 11102488, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lev-9
    NP_001335574.1
    • Confirmed by transcript evidence
    NP_001335575.1
    • Partially confirmed by transcript evidence
    NP_509053.3
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6281847..6291732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348599.3 → NP_001335574.1  Protein lev-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYU8
      Conserved Domains (3) summary
      cd00033
      Location:64 → 119
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00156
      Location:18 → 61
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      cl27761
      Location:127 → 363
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    2. NM_001348600.3 → NP_001335575.1  Protein lev-9 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SZ15
      Conserved Domains (3) summary
      cd00033
      Location:64 → 119
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00156
      Location:18 → 61
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      cl27761
      Location:127 → 363
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    3. NM_076652.8 → NP_509053.3  Protein lev-9 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509053.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C7C692, Q22328
      Conserved Domains (4) summary
      cd00033
      Location:193 → 247
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:377 → 557
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:309 → 362
      Sushi; Sushi repeat (SCR repeat)
      cl00156
      Location:18 → 61
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22328.3

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