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    unc-14 RUN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172450, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-14
    Official Full Name
    RUN domain-containing protein
    Primary source
    WormBase:WBGene00006753
    Locus tag
    CELE_K10D3.2
    See related
    AllianceGenome:WB:WBGene00006753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity and scaffold protein binding activity. Involved in regulation of protein localization and synaptic vesicle localization. Located in neuron projection. Is expressed in several structures, including hypodermis; intestine; motor neurons; muscle cell; and uterus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 61. Orthologous to human RUSC1 (RUN and SH3 domain containing 1) and RUSC2 (RUN and SH3 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (7122614..7128246, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glutamate receptor ionotropic, kainate glr-3 Neighboring gene Uncharacterized protein Neighboring gene TAFII28-like protein domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables scaffold protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle  
    located_in neuron projection PubMed 

    General protein information

    Preferred Names
    RUN domain-containing protein
    NP_492018.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7122614..7128246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059617.7NP_492018.1  RUN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECQ1
      Conserved Domains (1) summary
      smart00593
      Location:471535
      RUN; domain involved in Ras-like GTPase signaling
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