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unc-16 JNK-interacting protein [ Caenorhabditis elegans ]

Gene ID: 176349, updated on 23-Jan-2025

Summary

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Official Symbol
unc-16
Official Full Name
JNK-interacting protein
Primary source
WormBase:WBGene00006755
Locus tag
CELE_ZK1098.10
See related
AllianceGenome:WB:WBGene00006755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables kinase binding activity; kinesin binding activity; and signaling adaptor activity. Involved in several processes, including defecation; egg-laying behavior; and regulation of JNK cascade. Located in axon; cell body; and cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to several human genes including MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See unc-16 in Genome Data Viewer
Location:
chromosome: III
Exon count:
27
Sequence:
Chromosome: III; NC_003281.10 (9546258..9557450)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene DUF2975 domain-containing protein Neighboring gene ncRNA Neighboring gene Protein NATD1 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking at C. elegans synapses. Brown HM, et al. Dev Neurobiol, 2009 Feb 1-15. PMID 19105215, Free PMC Article
  2. UNC-16/JIP3/sunday driver: a new cop on the organelle highway. Zheng Q, et al. Genetics, 2013 May. PMID 23633141, Free PMC Article
  3. Microtubule-dependent ribosome localization in C. elegans neurons. Noma K, et al. Elife, 2017 Aug 2. PMID 28767038, Free PMC Article
  4. UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons. Kulkarni SS, et al. Genetics, 2021 Nov 5. PMID 34740241, Free PMC Article
  5. UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport. Sure GR, et al. Sci Rep, 2018 Jun 12. PMID 29895958, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.
    Title: UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.
  2. UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
    Title: UNC-116 and UNC-16 function with the NEKL-3 kinase to promote axon targeting.
  3. UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.
    Title: UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons.
  4. Data show that mutants in UNC-16 and UNC-76 increased mitochondrial density and also have elevated levels of both the Kinesin Heavy and Light Chains in neurons.
    Title: UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport.
  5. Data reveal a new and unprecedented role for 2 synapse assembly proteins, SAD-1 and SYD-2, in mediating UNC-16's organelle transport regulatory function.
    Title: UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons.
  6. an organelle gatekeeper model is suggested in which UNC-16 (JIP3/Sunday Driver) selectively inhibits the escape of Golgi and endosomal organelles from the axon initial segment.
    Title: An organelle gatekeeper function for Caenorhabditis elegans UNC-16 (JIP3) at the axon initial segment.
  7. putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-alpha), inherit different functions in steering UNC-104 to specific sub-cellular locations in the neuron
    Title: Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons.
  8. These results support the possibility that UNC-16 acts as an adaptor that links kinesin-1 and dynein for anterograde transport of dynein, which mediates APL-1 retrograde transport.
    Title: The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein.
  9. unc-14 binds to kinesin-1 and unc-16 complex and regulates synaptic vesicle localization.
    Title: The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP-kinase scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor complex adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon initial segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
JNK-interacting protein
NP_001022981.1
  • Confirmed by transcript evidence
NP_001122747.1
  • Confirmed by transcript evidence
NP_001122748.1
  • Confirmed by transcript evidence
NP_001255008.1
  • Confirmed by transcript evidence
NP_001255009.1
  • Confirmed by transcript evidence
NP_001293608.1
  • Confirmed by transcript evidence
NP_001293609.1
  • Confirmed by transcript evidence
NP_001293611.1
  • Partially confirmed by transcript evidence
NP_001293612.1
  • Partially confirmed by transcript evidence
NP_001293613.1
  • Partially confirmed by transcript evidence
NP_001293614.1
  • Partially confirmed by transcript evidence
NP_001293615.1
  • Partially confirmed by transcript evidence
NP_001293616.1
  • Confirmed by transcript evidence
NP_001293617.1
  • Confirmed by transcript evidence
NP_001380131.1
  • Confirmed by transcript evidence
NP_741263.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9546258..9557450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171221.7 → NP_741263.3  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741263.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34609
    Conserved Domains (4) summary
    pfam03286
    Location:186 → 287
    Pox_Ag35; Pox virus Ag35 surface protein
    pfam09744
    Location:6 → 159
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam14075
    Location:363 → 417
    UBN_AB; Ubinuclein conserved middle domain
    pfam16471
    Location:314 → 382
    JIP_LZII; JNK-interacting protein leucine zipper II

  2. NM_001268079.4 → NP_001255008.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255008.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7LPE3, A7LPE4, C0P271, C7FZT6, P34609, Q95V72, S6EZN6, S6EZP3, S6F548, S6F556, S6FD02, S6FN04, S6FN08, S6FWP4, S6FWP6, U4MKU8
    Conserved Domains (4) summary
    COG1196
    Location:75 → 486
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09744
    Location:41 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:365 → 433
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam19056
    Location:788 → 1052
    WD40_2; WD40 repeated domain

  3. NM_001129276.3 → NP_001122748.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPE4
    Conserved Domains (4) summary
    pfam03286
    Location:222 → 402
    Pox_Ag35; Pox virus Ag35 surface protein
    pfam09744
    Location:42 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam14075
    Location:381 → 435
    UBN_AB; Ubinuclein conserved middle domain
    pfam16471
    Location:332 → 400
    JIP_LZII; JNK-interacting protein leucine zipper II

  4. NM_001027810.5 → NP_001022981.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022981.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34609
    Conserved Domains (4) summary
    pfam03286
    Location:222 → 402
    Pox_Ag35; Pox virus Ag35 surface protein
    pfam09744
    Location:42 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam14075
    Location:381 → 435
    UBN_AB; Ubinuclein conserved middle domain
    pfam16471
    Location:332 → 400
    JIP_LZII; JNK-interacting protein leucine zipper II

  5. NM_001392177.1 → NP_001380131.1  JNK-interacting protein [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam09744
    Location:41 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam14075
    Location:414 → 468
    UBN_AB; Ubinuclein conserved middle domain
    pfam16471
    Location:365 → 420
    JIP_LZII; JNK-interacting protein leucine zipper II

  6. NM_001306680.3 → NP_001293609.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FN04
    Conserved Domains (2) summary
    pfam09744
    Location:42 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:338 → 406
    JIP_LZII; JNK-interacting protein leucine zipper II

  7. NM_001306685.3 → NP_001293614.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293614.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6EZP3
    Conserved Domains (3) summary
    pfam03286
    Location:241 → 342
    Pox_Ag35; Pox virus Ag35 surface protein
    pfam09744
    Location:42 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:402 → 470
    JIP_LZII; JNK-interacting protein leucine zipper II

  8. NM_001306686.3 → NP_001293615.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293615.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FN08
    Conserved Domains (2) summary
    pfam09744
    Location:42 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:350 → 418
    JIP_LZII; JNK-interacting protein leucine zipper II

  9. NM_001306684.3 → NP_001293613.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FD02
    Conserved Domains (2) summary
    pfam09744
    Location:42 → 195
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:344 → 412
    JIP_LZII; JNK-interacting protein leucine zipper II

  10. NM_001306682.3 → NP_001293611.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    U4MKU8
    Conserved Domains (2) summary
    pfam09744
    Location:6 → 159
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:347 → 415
    JIP_LZII; JNK-interacting protein leucine zipper II

  11. NM_001268080.3 → NP_001255009.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255009.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7FZT6
    Conserved Domains (2) summary
    pfam15619
    Location:109 → 201
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16471
    Location:83 → 151
    JIP_LZII; JNK-interacting protein leucine zipper II

  12. NM_001306683.3 → NP_001293612.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6F548
    Conserved Domains (2) summary
    pfam14075
    Location:183 → 237
    UBN_AB; Ubinuclein conserved middle domain
    pfam16471
    Location:134 → 202
    JIP_LZII; JNK-interacting protein leucine zipper II

  13. NM_001306687.3 → NP_001293616.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293616.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FWP6
    Conserved Domains (2) summary
    pfam15619
    Location:47 → 139
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16471
    Location:21 → 89
    JIP_LZII; JNK-interacting protein leucine zipper II

  14. NM_001306679.3 → NP_001293608.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293608.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6EZN6
    Conserved Domains (2) summary
    pfam15619
    Location:41 → 133
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16471
    Location:15 → 83
    JIP_LZII; JNK-interacting protein leucine zipper II

  15. NM_001306688.3 → NP_001293617.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293617.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6F556

  16. NM_001129275.4 → NP_001122747.1  JNK-interacting protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPE3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34609.4

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