U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CA2 carbonic anhydrase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831326, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CA2
    Official Full Name
    carbonic anhydrase 2
    Primary source
    TAIR:AT5G14740
    Locus tag
    AT5G14740
    See related
    Araport:AT5G14740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BETA CA2; BETA CARBONIC ANHYDRASE 2; CA18; CARBONIC ANHYDRASE 18; carbonic anhydrase 2; CARBONIC ANHYDRASE 2; T9L3.40; T9L3_40
    Summary
    Encodes a beta carbonic anhydrase likely to be localized in the cytoplasm. Expression of its mRNA is seen in etiolated seedlings and points to a possible nonphotosynthetic role for this isoform.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CA2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (4757856..4762666)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene proteasome assembly chaperone-like protein Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein Neighboring gene myb domain protein 66 Neighboring gene L-aspartate oxidase Neighboring gene PPR repeat protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization and expression of two cDNAs encoding carbonic anhydrase in Arabidopsis thaliana. Fett JP, et al. Plant Physiol, 1994 Jun. PMID 7520589, Free PMC Article
    2. The Cytoplasmic Carbonic Anhydrases βCA2 and βCA4 Are Required for Optimal Plant Growth at Low CO2. DiMario RJ, et al. Plant Physiol, 2016 May. PMID 26993617, Free PMC Article
    3. Characterization and expression analysis of genes encoding alpha and beta carbonic anhydrases in Arabidopsis. Fabre N, et al. Plant Cell Environ, 2007 May. PMID 17407539
    4. Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants. Sunderhaus S, et al. J Biol Chem, 2006 Mar 10. PMID 16407270
    5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytoplasmic CA2 plays an important role in amino acid biosynthesis and plant growth at low CO2.
      Title: The Cytoplasmic Carbonic Anhydrases βCA2 and βCA4 Are Required for Optimal Plant Growth at Low CO2.
    2. CA2 is an integral membrane protein localized on the matrix-exposed side of the membrane arm of complex I.
      Title: Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001036806.2
    NM_001036807.1
    NM_001085114.1
    NM_001343359.1
    NM_001343360.1
    NM_001343361.1
    NM_001343362.1
    NM_121478.4
    NM_203053.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbon utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    carbonic anhydrase 2
    NP_001031883.1
    • carbonic anhydrase 2 (CA2); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: defense response to bacterium, carbon utilization; LOCATED IN: cytosol, chloroplast thylakoid membrane, apoplast, chloroplast, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, prokaryotic-like, conserved site (InterPro:IPR015892), Carbonic anhydrase (InterPro:IPR001765); BEST Arabidopsis thaliana protein match is: carbonic anhydrase 1 (TAIR:AT3G01500.3); Has 5107 Blast hits to 5090 proteins in 1530 species: Archae - 36; Bacteria - 3948; Metazoa - 60; Fungi - 213; Plants - 355; Viruses - 0; Other Eukaryotes - 495 (source: NCBI BLink).
    NP_001031884.1
    • carbonic anhydrase 2 (CA2); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: defense response to bacterium, carbon utilization; LOCATED IN: cytosol, chloroplast thylakoid membrane, apoplast, chloroplast, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, prokaryotic-like, conserved site (InterPro:IPR015892), Carbonic anhydrase (InterPro:IPR001765); BEST Arabidopsis thaliana protein match is: carbonic anhydrase 1 (TAIR:AT3G01500.3); Has 5114 Blast hits to 5097 proteins in 1529 species: Archae - 36; Bacteria - 3948; Metazoa - 60; Fungi - 213; Plants - 357; Viruses - 0; Other Eukaryotes - 500 (source: NCBI BLink).
    NP_001078583.1
    • carbonic anhydrase 2 (CA2); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: defense response to bacterium, carbon utilization; LOCATED IN: cytosol, chloroplast thylakoid membrane, apoplast, chloroplast, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, prokaryotic-like, conserved site (InterPro:IPR015892), Carbonic anhydrase (InterPro:IPR001765); BEST Arabidopsis thaliana protein match is: carbonic anhydrase 1 (TAIR:AT3G01500.2); Has 5023 Blast hits to 5008 proteins in 1512 species: Archae - 36; Bacteria - 3889; Metazoa - 60; Fungi - 203; Plants - 352; Viruses - 0; Other Eukaryotes - 483 (source: NCBI BLink).
    NP_568303.2
    • carbonic anhydrase 2 (CA2); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: defense response to bacterium, carbon utilization; LOCATED IN: in 7 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, prokaryotic-like, conserved site (InterPro:IPR015892), Carbonic anhydrase (InterPro:IPR001765); BEST Arabidopsis thaliana protein match is: carbonic anhydrase 1 (TAIR:AT3G01500.2); Has 5122 Blast hits to 5105 proteins in 1527 species: Archae - 36; Bacteria - 3955; Metazoa - 59; Fungi - 207; Plants - 361; Viruses - 0; Other Eukaryotes - 504 (source: NCBI BLink).
    NP_974782.1
    • carbonic anhydrase 2 (CA2); FUNCTIONS IN: carbonate dehydratase activity, zinc ion binding; INVOLVED IN: defense response to bacterium, carbon utilization; LOCATED IN: cytosol, chloroplast thylakoid membrane, apoplast, chloroplast, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbonic anhydrase, prokaryotic-like, conserved site (InterPro:IPR015892), Carbonic anhydrase (InterPro:IPR001765); BEST Arabidopsis thaliana protein match is: carbonic anhydrase 1 (TAIR:AT3G01500.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4757856..4762666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036806.2 → NP_001031883.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K873
      Conserved Domains (2) summary
      PLN03019
      Location:1 → 330
      PLN03019; carbonic anhydrase
      cl00391
      Location:73 → 326
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    2. NM_001343359.1 → NP_001330235.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UT81, A0A654G125
      Conserved Domains (1) summary
      PLN03019
      Location:1 → 259
      PLN03019; carbonic anhydrase

    3. NM_001343360.1 → NP_001330236.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UT81, A0A654G125
      Conserved Domains (1) summary
      PLN03019
      Location:1 → 259
      PLN03019; carbonic anhydrase

    4. NM_001343361.1 → NP_001330237.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UT81, A0A654G125
      Conserved Domains (1) summary
      PLN03019
      Location:1 → 259
      PLN03019; carbonic anhydrase

    5. NM_121478.4 → NP_568303.2  carbonic anhydrase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568303.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHN2, F4K874, P42737, Q42116, Q9FDZ0, Q9LER2
      Conserved Domains (1) summary
      PLN03019
      Location:1 → 331
      PLN03019; carbonic anhydrase

    6. NM_203053.2 → NP_974782.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UT81, A0A654G125
      Conserved Domains (1) summary
      PLN03019
      Location:1 → 259
      PLN03019; carbonic anhydrase

    7. NM_001085114.1 → NP_001078583.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MQY4
      Conserved Domains (2) summary
      PLN03019
      Location:1 → 310
      PLN03019; carbonic anhydrase
      cl00391
      Location:73 → 277
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    8. NM_001036807.1 → NP_001031884.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K875
      Conserved Domains (2) summary
      PLN03019
      Location:1 → 330
      PLN03019; carbonic anhydrase
      cl00391
      Location:73 → 326
      beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

    9. NM_001343362.1 → NP_001330238.1  carbonic anhydrase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UT81, A0A654G125
      Conserved Domains (1) summary
      PLN03019
      Location:1 → 259
      PLN03019; carbonic anhydrase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42737.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.