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Conserved domains on  [gi|30685030|ref|NP_568303|]
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carbonic anhydrase 2 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN03019 PLN03019
carbonic anhydrase
1-331 0e+00

carbonic anhydrase


:

Pssm-ID: 166660  Cd Length: 330  Bit Score: 641.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
Cdd:PLN03019   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
Cdd:PLN03019  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
Cdd:PLN03019 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEReAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWE 320
Cdd:PLN03019 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-AVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWE 319
                        330
                 ....*....|.
gi 30685030  321 LQFGISPVHSI 331
Cdd:PLN03019 320 LQFGISPVHSI 330
 
Name Accession Description Interval E-value
PLN03019 PLN03019
carbonic anhydrase
1-331 0e+00

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 641.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
Cdd:PLN03019   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
Cdd:PLN03019  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
Cdd:PLN03019 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEReAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWE 320
Cdd:PLN03019 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-AVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWE 319
                        330
                 ....*....|.
gi 30685030  321 LQFGISPVHSI 331
Cdd:PLN03019 320 LQFGISPVHSI 330
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
130-319 7.76e-103

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 299.84  E-value: 7.76e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 130 GFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDK-VKYAGVGAAIEYA 208
Cdd:cd00884   1 GFRRFRKEYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPdGGFHGTSAAIEYA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 209 VLHLKVENIVVIGHSACGGIKGLMSFPlDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEREAVNVSLANLL 288
Cdd:cd00884  81 VAVLKVEHIVVCGHSDCGGIRALLSPE-DLLDKLPFIGKWLRIAEPAKEVVLAELSHADFDDQLRALEKENVLLSLENLL 159
                       170       180       190
                ....*....|....*....|....*....|.
gi 30685030 289 TYPFVREGVVKGTLALKGGYYDFVNGSFELW 319
Cdd:cd00884 160 TYPFVRERLEAGTLSLHGWYYDIETGELYAY 190
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
125-314 2.58e-71

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 220.04  E-value: 2.58e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 125 ERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAA 204
Cdd:COG0288   5 KRLLEGNRRFVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYD----PGVLAS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 205 IEYAVLHLKVENIVVIGHSACGGIKGLMSfpLDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEREAVNVSL 284
Cdd:COG0288  81 IEYAVEVLGVKLIVVLGHSGCGAVKAALD--GLELEELGLIGNWLRHIRPAVERVRAELPAADGEERLDRLVELNVREQV 158
                       170       180       190
                ....*....|....*....|....*....|
gi 30685030 285 ANLLTYPFVREGVVKGTLALKGGYYDFVNG 314
Cdd:COG0288 159 ENLRTSPIVREAVAAGKLKVHGWVYDLATG 188
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
157-314 2.58e-62

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 195.42  E-value: 2.58e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   157 YMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSfPL 236
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYD----LNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALD-AA 75
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30685030   237 DGNNSTDFIEDWVKICLPAKSKVLAESESS-AFEDQCGRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNG 314
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLdDPEERDDALEELNVREQVENLRTFPIVREAVAKGKLKIHGWVYDLETG 154
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
150-321 1.32e-58

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 185.79  E-value: 1.32e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    150 AKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIK 229
Cdd:smart00947   1 AKGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYD----DGVLASLEYAVEVLGVKEIVVCGHTDCGAVK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    230 GLMsfpldgNNSTDFIEDWVKICLPAKSKVLAESESSAfedqcgRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYY 309
Cdd:smart00947  77 AAL------DDEPGLIDNWLERIRPARERALEELGDVD------ALEELNVRDQVENLRTSPAIREAVAKGKLKVHGWVY 144
                          170
                   ....*....|..
gi 30685030    310 DFVNGsfELWEL 321
Cdd:smart00947 145 DIETG--KLEVL 154
 
Name Accession Description Interval E-value
PLN03019 PLN03019
carbonic anhydrase
1-331 0e+00

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 641.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
Cdd:PLN03019   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
Cdd:PLN03019  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
Cdd:PLN03019 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEReAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWE 320
Cdd:PLN03019 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-AVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWE 319
                        330
                 ....*....|.
gi 30685030  321 LQFGISPVHSI 331
Cdd:PLN03019 320 LQFGISPVHSI 330
PLN03014 PLN03014
carbonic anhydrase
73-331 2.90e-170

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 476.92  E-value: 2.90e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   73 MGNESYEDAIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKG 152
Cdd:PLN03014  78 MGTEAYDEAIEALKKLLIEKEELKTVAAAKVEQITAALQTGTSSDKKAFDPVETIKQGFIKFKKEKYETNPALYGELAKG 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 232
Cdd:PLN03014 158 QSPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPFDKVKYGGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  233 SFPLDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFV 312
Cdd:PLN03014 238 SFPLDGNNSTDFIEDWVKICLPAKSKVISELGDSAFEDQCGRCEREAVNVSLANLLTYPFVREGLVKGTLALKGGYYDFV 317
                        250
                 ....*....|....*....
gi 30685030  313 NGSFELWELQFGISPVHSI 331
Cdd:PLN03014 318 KGAFELWGLEFGLSETSSV 336
PLN00416 PLN00416
carbonate dehydratase
73-327 4.31e-138

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 391.71  E-value: 4.31e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   73 MGNESYEDAIEALKKLLIEKDDLKDVAAAKVKKITAELQAAsssDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKG 152
Cdd:PLN00416   1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKEL---DSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 232
Cdd:PLN00416  78 QTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLM 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  233 SFPLD-GNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDF 311
Cdd:PLN00416 158 SIEDDaAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNF 237
                        250
                 ....*....|....*.
gi 30685030  312 VNGSFELWELQFGISP 327
Cdd:PLN00416 238 VKGTFDLWELDFKTTP 253
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
130-319 7.76e-103

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 299.84  E-value: 7.76e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 130 GFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDK-VKYAGVGAAIEYA 208
Cdd:cd00884   1 GFRRFRKEYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPdGGFHGTSAAIEYA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 209 VLHLKVENIVVIGHSACGGIKGLMSFPlDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEREAVNVSLANLL 288
Cdd:cd00884  81 VAVLKVEHIVVCGHSDCGGIRALLSPE-DLLDKLPFIGKWLRIAEPAKEVVLAELSHADFDDQLRALEKENVLLSLENLL 159
                       170       180       190
                ....*....|....*....|....*....|.
gi 30685030 289 TYPFVREGVVKGTLALKGGYYDFVNGSFELW 319
Cdd:cd00884 160 TYPFVRERLEAGTLSLHGWYYDIETGELYAY 190
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
125-314 2.58e-71

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 220.04  E-value: 2.58e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 125 ERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAA 204
Cdd:COG0288   5 KRLLEGNRRFVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYD----PGVLAS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 205 IEYAVLHLKVENIVVIGHSACGGIKGLMSfpLDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCEREAVNVSL 284
Cdd:COG0288  81 IEYAVEVLGVKLIVVLGHSGCGAVKAALD--GLELEELGLIGNWLRHIRPAVERVRAELPAADGEERLDRLVELNVREQV 158
                       170       180       190
                ....*....|....*....|....*....|
gi 30685030 285 ANLLTYPFVREGVVKGTLALKGGYYDFVNG 314
Cdd:COG0288 159 ENLRTSPIVREAVAAGKLKVHGWVYDLATG 188
PLN03006 PLN03006
carbonate dehydratase
94-326 6.81e-64

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 204.59  E-value: 6.81e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   94 DLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVL 173
Cdd:PLN03006  52 NLQVMASGKTPGLTQEANGVAIDRQNNTDVFDDMKQRFLAFKKLKYMDDFEHYKNLADAQAPKFLVIACADSRVCPSAVL 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  174 DFHPGDAFVVRNIANMVPPFDKVKyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGnNSTDFIEDWVKICL 253
Cdd:PLN03006 132 GFQPGDAFTVRNIANLVPPYESGP-TETKAALEFSVNTLNVENILVIGHSRCGGIQALMKMEDEG-DSRSFIHNWVVVGK 209
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30685030  254 PAKSKVLAESESSAFEDQCGRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWELQFGIS 326
Cdd:PLN03006 210 KAKESTKAVASNLHFDHQCQHCEKASINHSLERLLGYPWIEEKVRQGSLSLHGGYYNFVDCTFEKWTVDYAAS 282
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
157-314 2.58e-62

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 195.42  E-value: 2.58e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030   157 YMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSfPL 236
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYD----LNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALD-AA 75
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30685030   237 DGNNSTDFIEDWVKICLPAKSKVLAESESS-AFEDQCGRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNG 314
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLdDPEERDDALEELNVREQVENLRTFPIVREAVAKGKLKIHGWVYDLETG 154
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
150-321 1.32e-58

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 185.79  E-value: 1.32e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    150 AKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIK 229
Cdd:smart00947   1 AKGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYD----DGVLASLEYAVEVLGVKEIVVCGHTDCGAVK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030    230 GLMsfpldgNNSTDFIEDWVKICLPAKSKVLAESESSAfedqcgRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYY 309
Cdd:smart00947  77 AAL------DDEPGLIDNWLERIRPARERALEELGDVD------ALEELNVRDQVENLRTSPAIREAVAKGKLKVHGWVY 144
                          170
                   ....*....|..
gi 30685030    310 DFVNGsfELWEL 321
Cdd:smart00947 145 DIETG--KLEVL 154
PLN02154 PLN02154
carbonic anhydrase
106-321 5.54e-53

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 176.09  E-value: 5.54e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  106 ITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRN 185
Cdd:PLN02154  58 IREEFMDLNRETETSYDFLDEMRHRFLKFKRQKYLPEIEKFKALAIAQSPKVMVIGCADSRVCPSYVLGFQPGEAFTIRN 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  186 IANMVPPFDKVKyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVLAESES 265
Cdd:PLN02154 138 VANLVTPVQNGP-TETNSALEFAVTTLQVENIIVMGHSNCGGIAALMSHQNHQGQHSSLVERWVMNGKAAKLRTQLASSH 216
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 30685030  266 SAFEDQCGRCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFVNGSFELWEL 321
Cdd:PLN02154 217 LSFDEQCRNCEKESIKDSVMNLITYSWIRDRVKRGEVKIHGCYYNLSDCSLEKWRL 272
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
153-319 2.95e-47

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 155.35  E-value: 2.95e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGlm 232
Cdd:cd00382   1 QKPKALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPPYD----LDVLASLEYAVEVLGVKHIIVCGHTDCGAVKA-- 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 233 sfpldgnnstdfiedwvkiclpakskvlaesessafedqcgrCEREAVNVSLANLLTYPFVREGVVKGTLALKGGYYDFV 312
Cdd:cd00382  75 ------------------------------------------LVEENVREQVENLRSHPLIQEAVAPGELKVHGWVYDIE 112

                ....*..
gi 30685030 313 NGSFELW 319
Cdd:cd00382 113 TGKLEVL 119
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
136-229 2.15e-33

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 121.52  E-value: 2.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 136 KEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVE 215
Cdd:cd00883   6 EEKKAKDPDFFPRLAKGQTPEYLWIGCSDSRVPENTILGLLPGEVFVHRNIANLVSPTD----LNCLSVLQYAVDVLKVK 81
                        90
                ....*....|....
gi 30685030 216 NIVVIGHSACGGIK 229
Cdd:cd00883  82 HIIVCGHYGCGGVK 95
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
125-230 2.01e-24

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 96.83  E-value: 2.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030 125 ERIKEG---FVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPfdkvkyaGV 201
Cdd:cd03378   6 ERLKEGnkrFVSGKPLHPDQDLARRRELAKGQKPFAVILSCSDSRVPPEIIFDQGLGDLFVVRVAGNIVDD-------DV 78
                        90       100
                ....*....|....*....|....*....
gi 30685030 202 GAAIEYAVLHLKVENIVVIGHSACGGIKG 230
Cdd:cd03378  79 LGSLEYAVEVLGVPLVVVLGHESCGAVAA 107
PRK10437 PRK10437
carbonic anhydrase; Provisional
140-250 2.71e-17

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 79.21  E-value: 2.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  140 ETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVV 219
Cdd:PRK10437  20 EEDPGFFEKLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTD----LNCLSVVQYAVDVLEVEHIII 95
                         90       100       110
                 ....*....|....*....|....*....|....
gi 30685030  220 IGHSACGGIKGLMSFPLDG--NNSTDFIED-WVK 250
Cdd:PRK10437  96 CGHYGCGGVQAAVENPELGliNNWLLHIRDiWFK 129
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
154-226 1.11e-07

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 50.33  E-value: 1.11e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30685030 154 SPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVppfdkvkyagVGAAIEYAVL---HLKVENIVVIGHSACG 226
Cdd:cd03379   2 ARKLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRV----------TDDAIRSLVVsvyLLGTREIIVIHHTDCG 67
PRK15219 PRK15219
carbonic anhydrase; Provisional
150-320 1.49e-07

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 51.76  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  150 AKGQSPKYMVFACSDSRVCPSHVLDFHPGDAF---VVRNIANmvppfdkvkyAGVGAAIEYAVLHLKVENIVVIGHSACG 226
Cdd:PRK15219  85 AAGQYPAAVILSCIDSRAPAEIILDTGIGETFnsrVAGNISN----------DDLLGSMEFACAVAGAKVVLVMGHTACG 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30685030  227 GIKGLMSFPLDGNNSTdfIEDWVKiclPAKSKVLAESE-SSAFEDQCGRCEREAVNVSLANLL-TYPFVREGVVKGTLAL 304
Cdd:PRK15219 155 AVKGAIDNVELGNLTG--LLDRIK---PAIEVTEFDGErSSKNYKFVDAVARKNVELTIENIRkNSPILRKLEQEGKIKI 229
                        170
                 ....*....|....*.
gi 30685030  305 KGGYYDFVNGSFELWE 320
Cdd:PRK15219 230 VGSMYNLNGGKVEFFM 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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