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Conserved domains on  [gi|145334412|ref|NP_001078583|]
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carbonic anhydrase 2 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03019 super family cl28980
carbonic anhydrase
 1-310 0e+00

carbonic anhydrase


The actual alignment was detected with superfamily member PLN03019:

Pssm-ID: 166660  Cd Length: 330  Bit Score: 579.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
Cdd:PLN03019   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
Cdd:PLN03019  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
Cdd:PLN03019 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-------------------VRGSECVTSKPIDISicerrscer 301
Cdd:PLN03019 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCERavnvslanlltypfvregvVKGTLALKGGYYDFV--------- 311


                 ....*....
gi 145334412 302 NTCFEGRLL 310
Cdd:PLN03019 312 NGSFELWEL 320
 
Name Accession Description Interval E-value
PLN03019 PLN03019
carbonic anhydrase
 1-310 0e+00

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 579.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
Cdd:PLN03019   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
Cdd:PLN03019  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
Cdd:PLN03019 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-------------------VRGSECVTSKPIDISicerrscer 301
Cdd:PLN03019 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCERavnvslanlltypfvregvVKGTLALKGGYYDFV--------- 311


                 ....*....
gi 145334412 302 NTCFEGRLL 310
Cdd:PLN03019 312 NGSFELWEL 320
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 130-277 6.25e-77

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 233.20  E-value: 6.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 130 GFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDK-VKYAGVGAAIEYA 208
Cdd:cd00884    1 GFRRFRKEYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPdGGFHGTSAAIEYA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145334412 209 VLHLKVENIVVIGHSACGGIKGLMSFPlDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER 277
Cdd:cd00884   81 VAVLKVEHIVVCGHSDCGGIRALLSPE-DLLDKLPFIGKWLRIAEPAKEVVLAELSHADFDDQLRALEK 148
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
125-277 1.87e-55

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 178.82  E-value: 1.87e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 125 ERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAA 204
Cdd:COG0288    5 KRLLEGNRRFVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYD----PGVLAS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334412 205 IEYAVLHLKVENIVVIGHSACGGIKGLMSfpLDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER 277
Cdd:COG0288   81 IEYAVEVLGVKLIVVLGHSGCGAVKAALD--GLELEELGLIGNWLRHIRPAVERVRAELPAADGEERLDRLVE 151
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 150-288 1.89e-45

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 151.12  E-value: 1.89e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412   150 AKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIK 229
Cdd:smart00947   1 AKGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYD----DGVLASLEYAVEVLGVKEIVVCGHTDCGAVK 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334412   230 GLMsfpldgNNSTDFIEDWVKICLPAKSKVLAESESS------AFEDQcgrCERVRGSECVTSKP 288
Cdd:smart00947  77 AAL------DDEPGLIDNWLERIRPARERALEELGDVdaleelNVRDQ---VENLRTSPAIREAV 132
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 157-278 2.33e-44

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 148.43  E-value: 2.33e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  157 YMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSfPL 236
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYD----LNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALD-AA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 145334412  237 DGNNSTDFIEDWVKICLPAKSKVLAESESS-AFEDQCGRCERV 278
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLdDPEERDDALEEL 118
 
Name Accession Description Interval E-value
PLN03019 PLN03019
carbonic anhydrase
 1-310 0e+00

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 579.02  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80
Cdd:PLN03019   1 MVPFWTTVSRNGSSDSETTLQSASKATKQYKYPSLRPSHRLSLLFLFPFHLSANGACFRCTCFSHFKLELRRMGNESYED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160
Cdd:PLN03019  81 AIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240
Cdd:PLN03019 161 ACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-------------------VRGSECVTSKPIDISicerrscer 301
Cdd:PLN03019 241 STDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCERavnvslanlltypfvregvVKGTLALKGGYYDFV--------- 311


                 ....*....
gi 145334412 302 NTCFEGRLL 310
Cdd:PLN03019 312 NGSFELWEL 320
PLN03014 PLN03014
carbonic anhydrase
 73-277 2.10e-134

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 384.86  E-value: 2.10e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  73 MGNESYEDAIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKG 152
Cdd:PLN03014  78 MGTEAYDEAIEALKKLLIEKEELKTVAAAKVEQITAALQTGTSSDKKAFDPVETIKQGFIKFKKEKYETNPALYGELAKG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 232
Cdd:PLN03014 158 QSPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPFDKVKYGGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 145334412 233 SFPLDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER 277
Cdd:PLN03014 238 SFPLDGNNSTDFIEDWVKICLPAKSKVISELGDSAFEDQCGRCER 282
PLN00416 PLN00416
carbonate dehydratase
 73-277 6.91e-105

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 306.58  E-value: 6.91e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  73 MGNESYEDAIEALKKLLIEKDDLKDVAAAKVKKITAELQAAsssDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKG 152
Cdd:PLN00416   1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKEL---DSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 232
Cdd:PLN00416  78 QTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLM 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 145334412 233 SFPLD-GNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER 277
Cdd:PLN00416 158 SIEDDaAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEK 203
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 130-277 6.25e-77

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 233.20  E-value: 6.25e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 130 GFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDK-VKYAGVGAAIEYA 208
Cdd:cd00884    1 GFRRFRKEYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPdGGFHGTSAAIEYA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145334412 209 VLHLKVENIVVIGHSACGGIKGLMSFPlDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER 277
Cdd:cd00884   81 VAVLKVEHIVVCGHSDCGGIRALLSPE-DLLDKLPFIGKWLRIAEPAKEVVLAELSHADFDDQLRALEK 148
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
125-277 1.87e-55

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 178.82  E-value: 1.87e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 125 ERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAA 204
Cdd:COG0288    5 KRLLEGNRRFVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYD----PGVLAS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334412 205 IEYAVLHLKVENIVVIGHSACGGIKGLMSfpLDGNNSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER 277
Cdd:COG0288   81 IEYAVEVLGVKLIVVLGHSGCGAVKAALD--GLELEELGLIGNWLRHIRPAVERVRAELPAADGEERLDRLVE 151
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 150-288 1.89e-45

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 151.12  E-value: 1.89e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412   150 AKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIK 229
Cdd:smart00947   1 AKGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYD----DGVLASLEYAVEVLGVKEIVVCGHTDCGAVK 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334412   230 GLMsfpldgNNSTDFIEDWVKICLPAKSKVLAESESS------AFEDQcgrCERVRGSECVTSKP 288
Cdd:smart00947  77 AAL------DDEPGLIDNWLERIRPARERALEELGDVdaleelNVRDQ---VENLRTSPAIREAV 132
PLN03006 PLN03006
carbonate dehydratase
 94-277 2.93e-45

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 155.67  E-value: 2.93e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  94 DLKDVAAAKVKKITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVL 173
Cdd:PLN03006  52 NLQVMASGKTPGLTQEANGVAIDRQNNTDVFDDMKQRFLAFKKLKYMDDFEHYKNLADAQAPKFLVIACADSRVCPSAVL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 174 DFHPGDAFVVRNIANMVPPFDKVKyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGnNSTDFIEDWVKICL 253
Cdd:PLN03006 132 GFQPGDAFTVRNIANLVPPYESGP-TETKAALEFSVNTLNVENILVIGHSRCGGIQALMKMEDEG-DSRSFIHNWVVVGK 209

                        170       180
                 ....*....|....*....|....
gi 145334412 254 PAKSKVLAESESSAFEDQCGRCER 277
Cdd:PLN03006 210 KAKESTKAVASNLHFDHQCQHCEK 233
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 157-278 2.33e-44

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 148.43  E-value: 2.33e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412  157 YMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSfPL 236
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYD----LNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALD-AA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 145334412  237 DGNNSTDFIEDWVKICLPAKSKVLAESESS-AFEDQCGRCERV 278
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLdDPEERDDALEEL 118
PLN02154 PLN02154
carbonic anhydrase
 106-277 8.92e-40

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 141.04  E-value: 8.92e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 106 ITAELQAASSSDSKSFDPVERIKEGFVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRN 185
Cdd:PLN02154  58 IREEFMDLNRETETSYDFLDEMRHRFLKFKRQKYLPEIEKFKALAIAQSPKVMVIGCADSRVCPSYVLGFQPGEAFTIRN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 186 IANMVPPFDKVKyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVLAESES 265
Cdd:PLN02154 138 VANLVTPVQNGP-TETNSALEFAVTTLQVENIIVMGHSNCGGIAALMSHQNHQGQHSSLVERWVMNGKAAKLRTQLASSH 216

                        170
                 ....*....|..
gi 145334412 266 SAFEDQCGRCER 277
Cdd:PLN02154 217 LSFDEQCRNCEK 228
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 153-231 6.72e-39

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 133.01  E-value: 6.72e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145334412 153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGL 231
Cdd:cd00382    1 QKPKALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPPYD----LDVLASLEYAVEVLGVKHIIVCGHTDCGAVKAL 75
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 136-229 1.33e-33

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 121.52  E-value: 1.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 136 KEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVE 215
Cdd:cd00883    6 EEKKAKDPDFFPRLAKGQTPEYLWIGCSDSRVPENTILGLLPGEVFVHRNIANLVSPTD----LNCLSVLQYAVDVLKVK 81

                         90
                 ....*....|....
gi 145334412 216 NIVVIGHSACGGIK 229
Cdd:cd00883   82 HIIVCGHYGCGGVK 95
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 125-230 9.77e-25

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 97.21  E-value: 9.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 125 ERIKEG---FVTFKKEKYETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPfdkvkyaGV 201
Cdd:cd03378    6 ERLKEGnkrFVSGKPLHPDQDLARRRELAKGQKPFAVILSCSDSRVPPEIIFDQGLGDLFVVRVAGNIVDD-------DV 78

                         90       100
                 ....*....|....*....|....*....
gi 145334412 202 GAAIEYAVLHLKVENIVVIGHSACGGIKG 230
Cdd:cd03378   79 LGSLEYAVEVLGVPLVVVLGHESCGAVAA 107
PRK10437 PRK10437
carbonic anhydrase; Provisional
 140-250 2.08e-17

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 79.21  E-value: 2.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 140 ETNPALYGELAKGQSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDkvkyAGVGAAIEYAVLHLKVENIVV 219
Cdd:PRK10437  20 EEDPGFFEKLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTD----LNCLSVVQYAVDVLEVEHIII 95

                         90       100       110
                 ....*....|....*....|....*....|....
gi 145334412 220 IGHSACGGIKGLMSFPLDG--NNSTDFIED-WVK 250
Cdd:PRK10437  96 CGHYGCGGVQAAVENPELGliNNWLLHIRDiWFK 129
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 154-226 1.40e-07

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 49.94  E-value: 1.40e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145334412 154 SPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVppfdkvkyagVGAAIEYAVL---HLKVENIVVIGHSACG 226
Cdd:cd03379    2 ARKLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRV----------TDDAIRSLVVsvyLLGTREIIVIHHTDCG 67
PRK15219 PRK15219
carbonic anhydrase; Provisional
 150-230 2.00e-06

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 48.29  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334412 150 AKGQSPKYMVFACSDSRVCPSHVLDFHPGDAF---VVRNIANmvppfdkvkyAGVGAAIEYAVLHLKVENIVVIGHSACG 226
Cdd:PRK15219  85 AAGQYPAAVILSCIDSRAPAEIILDTGIGETFnsrVAGNISN----------DDLLGSMEFACAVAGAKVVLVMGHTACG 154


                 ....
gi 145334412 227 GIKG 230
Cdd:PRK15219 155 AVKG 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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