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    Tspan32 tetraspanin 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tspan32provided by RGD
    Official Full Name
    tetraspanin 32provided by RGD
    Primary source
    RGD:1308721
    See related
    EnsemblRapid:ENSRNOG00000026039 AllianceGenome:RGD:1308721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phemx
    Summary
    Predicted to act upstream of or within several processes, including defense response to protozoan; integrin-mediated signaling pathway; and negative regulation of leukocyte activation. Predicted to be located in cell surface. Predicted to be part of integrin alphaIIb-beta3 complex. Predicted to be active in plasma membrane. Orthologous to human TSPAN32 (tetraspanin 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 59.1), Spleen (RPKM 42.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tspan32 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (207619566..207633885)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198190128..198204447)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216189535..216206202)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099959 Neighboring gene tyrosine hydroxylase Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene Cd81 molecule Neighboring gene tumor suppressing subtransferable candidate 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice. Goschnick MW, et al. Blood, 2006 Sep 15. PMID 16720835
    2. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Van Uden JH, et al. Eur J Immunol, 2001 Nov. PMID 11745345
    3. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. Gartlan KH, et al. J Immunol, 2010 Sep 15. PMID 20709950
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin alphaIIb-beta3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-32
    Names
    pan hematopoietic expression

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419843.1 → NP_001406772.1  tetraspanin-32

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HY89, A6HY92, F7F785

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      207619566..207633885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590274.2 → XP_017445763.1  tetraspanin-32 isoform X1

      UniProtKB/TrEMBL
      A6HY89, A6HY92, F7F785
      Related
      ENSRNOP00000102180.1, ENSRNOT00000156865.1
      Conserved Domains (2) summary
      cd03153
      Location:113 → 195
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:11 → 161
      Tetraspannin; Tetraspanin family

    2. XM_006230916.3 → XP_006230978.1  tetraspanin-32 isoform X3

      See identical proteins and their annotated locations for XP_006230978.1

      UniProtKB/TrEMBL
      A6HY92
      Conserved Domains (1) summary
      cl02781
      Location:113 → 199
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    3. XM_063269790.1 → XP_063125860.1  tetraspanin-32 isoform X6

    4. XM_006230915.3 → XP_006230977.1  tetraspanin-32 isoform X2

      See identical proteins and their annotated locations for XP_006230977.1

      UniProtKB/TrEMBL
      A6HY92
      Conserved Domains (1) summary
      cd03153
      Location:94 → 170
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

    5. XM_039101288.1 → XP_038957216.1  tetraspanin-32 isoform X4

      Conserved Domains (1) summary
      cl02781
      Location:94 → 174
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    6. XM_063269797.1 → XP_063125867.1  tetraspanin-32 isoform X9

    7. XM_039101290.1 → XP_038957218.1  tetraspanin-32 isoform X7

      UniProtKB/TrEMBL
      Q5I0J3
      Related
      ENSRNOP00000051746.4, ENSRNOT00000054863.6
      Conserved Domains (1) summary
      cl02781
      Location:74 → 140
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    8. XM_039101292.1 → XP_038957220.1  tetraspanin-32 isoform X10

      UniProtKB/TrEMBL
      Q5I0J3
      Conserved Domains (1) summary
      cl02781
      Location:74 → 112
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    9. XM_039101293.1 → XP_038957221.1  tetraspanin-32 isoform X11

      Conserved Domains (1) summary
      cl02781
      Location:94 → 127
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    10. XM_063269786.1 → XP_063125856.1  tetraspanin-32 isoform X5

    11. XM_039101291.1 → XP_038957219.1  tetraspanin-32 isoform X8

      Conserved Domains (1) summary
      cd03153
      Location:11 → 92
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    Nucleotide Protein Strain
    Heading Accession and Version

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