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Conserved domains on  [gi|1958654610|ref|XP_038957218|]
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tetraspanin-32 isoform X7 [Rattus norvegicus]

Protein Classification

tetraspanin family protein( domain architecture ID 548)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886|GO:0097197
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 74-140 1.02e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03153:

Pssm-ID: 351888  Cd Length: 87  Bit Score: 47.13  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958654610  74 LGAALSTIATVREAHGLMAA--------------------DCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWF 133
Cdd:cd03153     1 LHSPTQVEDAVLDTYDLVYEqalksisgsvrqelaaiqdtFLCCGKKSPFGLLGSTGATLCQGGEAMREVAMLLCLFLWF 80


                  ....*..
gi 1958654610 134 AIHSYCG 140
Cdd:cd03153    81 AILSGHG 87
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 74-140 1.02e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 47.13  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958654610  74 LGAALSTIATVREAHGLMAA--------------------DCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWF 133
Cdd:cd03153     1 LHSPTQVEDAVLDTYDLVYEqalksisgsvrqelaaiqdtFLCCGKKSPFGLLGSTGATLCQGGEAMREVAMLLCLFLWF 80


                  ....*..
gi 1958654610 134 AIHSYCG 140
Cdd:cd03153    81 AILSGHG 87
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 74-140 1.02e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 47.13  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958654610  74 LGAALSTIATVREAHGLMAA--------------------DCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWF 133
Cdd:cd03153     1 LHSPTQVEDAVLDTYDLVYEqalksisgsvrqelaaiqdtFLCCGKKSPFGLLGSTGATLCQGGEAMREVAMLLCLFLWF 80


                  ....*..
gi 1958654610 134 AIHSYCG 140
Cdd:cd03153    81 AILSGHG 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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