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Conserved domains on  [gi|564332530|ref|XP_006230978|]
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tetraspanin-32 isoform X3 [Rattus norvegicus]

Protein Classification

tetraspanin family protein( domain architecture ID 1001202)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL super family cl02781
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 113-199 6.27e-31

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


The actual alignment was detected with superfamily member cd03153:

Pssm-ID: 351888  Cd Length: 87  Bit Score: 109.15  E-value: 6.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530 113 FHNPTQVEDAVLDTYDLVYDQAMKSPSSSWWQELAVIQDTDCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWF 192
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMREVAMLLCLFLWF 80


                 ....*..
gi 564332530 193 AIHSYCG 199
Cdd:cd03153   81 AILSGHG 87
Tetraspanin super family cl28961
Tetraspanin family;
11-190 4.37e-03

Tetraspanin family;


The actual alignment was detected with superfamily member pfam00335:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 36.91  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530   11 KCQILITNFFVLLLGLSLATMTVVTHFGDHFTVIGHASLQRnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530   91 MAAGFLCFALSFCILVQVAFWRFHNPTQ--------VEDAVLDTYDLVYDQAMKSPSSswwqeLAVIQDT-----DCLQS 157
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKlsgllsnwLKKSLEDGYRDWLDLYSCLNSA-----LDSLQSEfgccgGCKEK 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 564332530  158 IRNFLWTHYRIAStLTCTSLALTVYAMMLCAFL 190
Cdd:pfam00335 149 LLEWLRKNLKIIG-AGVIALGVIQLLGIILACC 180
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-199 6.27e-31

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 109.15  E-value: 6.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530 113 FHNPTQVEDAVLDTYDLVYDQAMKSPSSSWWQELAVIQDTDCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWF 192
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMREVAMLLCLFLWF 80


                 ....*..
gi 564332530 193 AIHSYCG 199
Cdd:cd03153   81 AILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
11-190 4.37e-03

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 36.91  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530   11 KCQILITNFFVLLLGLSLATMTVVTHFGDHFTVIGHASLQRnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530   91 MAAGFLCFALSFCILVQVAFWRFHNPTQ--------VEDAVLDTYDLVYDQAMKSPSSswwqeLAVIQDT-----DCLQS 157
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKlsgllsnwLKKSLEDGYRDWLDLYSCLNSA-----LDSLQSEfgccgGCKEK 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 564332530  158 IRNFLWTHYRIAStLTCTSLALTVYAMMLCAFL 190
Cdd:pfam00335 149 LLEWLRKNLKIIG-AGVIALGVIQLLGIILACC 180
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-199 6.27e-31

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 109.15  E-value: 6.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530 113 FHNPTQVEDAVLDTYDLVYDQAMKSPSSSWWQELAVIQDTDCLQSIRNFLWTHYRIASTLTCTSLALTVYAMMLCAFLWF 192
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMREVAMLLCLFLWF 80


                 ....*..
gi 564332530 193 AIHSYCG 199
Cdd:cd03153   81 AILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
11-190 4.37e-03

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 36.91  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530   11 KCQILITNFFVLLLGLSLATMTVVTHFGDHFTVIGHASLQRnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564332530   91 MAAGFLCFALSFCILVQVAFWRFHNPTQ--------VEDAVLDTYDLVYDQAMKSPSSswwqeLAVIQDT-----DCLQS 157
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKlsgllsnwLKKSLEDGYRDWLDLYSCLNSA-----LDSLQSEfgccgGCKEK 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 564332530  158 IRNFLWTHYRIAStLTCTSLALTVYAMMLCAFL 190
Cdd:pfam00335 149 LLEWLRKNLKIIG-AGVIALGVIQLLGIILACC 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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