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    CG4860 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41480, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG4860provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037999
    Locus tag
    Dmel_CG4860
    See related
    AllianceGenome:FB:FBgn0037999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACAD11; ACADS; Dmel\CG4860
    Summary
    Predicted to enable short-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in butyrate catabolic process and fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be active in mitochondrion. Is expressed in embryonic/larval oenocyte and organism. Human ortholog(s) of this gene implicated in alcohol use disorder and short chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADS (acyl-CoA dehydrogenase short chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG4860 in Genome Data Viewer
    Location:
    87B2-87B2; 3-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12219881..12221464, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8045603..8047186, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 1 Neighboring gene antisense RNA:CR46012 Neighboring gene Radial spoke binding protein 15 Neighboring gene antisense RNA:CR43477 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity  
    enables acyl-CoA dehydrogenase activity PubMed 
    enables flavin adenine dinucleotide binding  
    enables short-chain fatty acyl-CoA dehydrogenase activity  
    Process Evidence Code Pubs
    involved_in butyrate catabolic process  
    involved_in fatty acid beta-oxidation PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase  
    Component Evidence Code Pubs
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG4860-PA
    NP_650163.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12219881..12221464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141906.4 → NP_650163.2  uncharacterized protein Dmel_CG4860 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650163.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95S48, Q9VGC2
      Related
      FBpp0082092
      Conserved Domains (2) summary
      cd01158
      Location:39 → 410
      SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases
      COG1960
      Location:37 → 414
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
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