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Sps1 Selenophosphate synthetase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36587, updated on 9-Dec-2024

Summary

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Official Symbol
Sps1provided by FlyBase
Official Full Name
Selenophosphate synthetase 1provided by FlyBase
Primary source
FLYBASE:FBgn0261270
Locus tag
Dmel_CG8553
See related
AllianceGenome:FB:FBgn0261270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
142926_at; anon-WO0172774.145; anon-WO0172774.146; CG8553; Dm SelD; Dm-SelD; Dmel\CG8553; dsps1; dSPS1; Dsps1; DSPS1; l(2)k12303; l(2)SH1599; l(2)SH2 1599; ptf1; ptuf; ptuf1; selD; SelD; SelD like; selD/sps1; SeS; SPS1
Summary
Predicted to enable ATP binding activity. Involved in negative regulation of mitochondrial fusion and negative regulation of reactive oxygen species metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; brain; embryonic/larval midgut; embryonic/larval optic lobe; and midgut primordium. Orthologous to several human genes including SEPHS2 (selenophosphate synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sps1 in Genome Data Viewer
Location:
50E6-50E6; 2-69 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14268772..14270658, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10156277..10158163, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene beta1,4-N-acetylgalactosaminyltransferase A Neighboring gene uncharacterized protein Neighboring gene convoluted Neighboring gene I[[h]] channel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of a selenophosphate synthetase from a collection of P-lacW insertion mutants in Drosophila. Alsina B, et al. Int J Dev Biol, 1996. PMID 9087708
  2. SelD homolog from Drosophila lacking selenide-dependent monoselenophosphate synthetase activity. Persson BC, et al. J Mol Biol, 1997 Nov 28. PMID 9398525
  3. Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster. Morey M, et al. FEBS Lett, 2003 Jan 16. PMID 12527370
  4. Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation. Lee KH, et al. BMC Genomics, 2011 Aug 24. PMID 21864351, Free PMC Article
  5. patufet, the gene encoding the Drosophila melanogaster homologue of selenophosphate synthetase, is involved in imaginal disc morphogenesis. Alsina B, et al. Mol Gen Genet, 1998 Jan. PMID 9491069

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the selenophosphate synthetase 1 regulate PLP bisynthesis, and the intracellular PLP level affects various biological process such as amino acid metabolism, defense and other important metabolic activities.
    Title: Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation.
  2. in Drosophila, SPS1/SelD regulates the intracellular glutamine by inhibiting GS1 and l(2)01810 expression
    Title: Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells.
  3. Our results strongly suggest that selD haploinsufficiency makes heterozygous flies more sensitive to oxidative stress and add further evidence to the role of selenoproteins as cellular antioxidants
    Title: Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables selenide, water dikinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables selenide, water dikinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables selenide, water dikinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
selenophosphate synthetase 1
Names
CG8553-PA
CG8553-PB
Selenide,water dikinase
Sps1-PA
Sps1-PB
lethal (2) SH1599
patufet
selD-like
selenophosphate synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14268772..14270658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166045.2 → NP_725374.1  selenophosphate synthetase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18373, O18597, Q0E979, Q9V700
    Related
    FBpp0086691
    Conserved Domains (1) summary
    cd02195
    Location:40 → 376
    SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...

  2. NM_166046.2 → NP_725375.1  selenophosphate synthetase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725375.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18373, O18597, Q0E979, Q9V700
    Related
    FBpp0086690
    Conserved Domains (1) summary
    cd02195
    Location:40 → 376
    SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18373.1 O18373

Gene LinkOut

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