U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ValRS Valyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45783, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ValRSprovided by FlyBase
    Official Full Name
    Valyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027079
    Locus tag
    Dmel_CG4062
    See related
    AllianceGenome:FB:FBgn0027079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aaRS(Val); aats-val; Aats-val; BEST:LD45671; CG4062; Dmel\CG4062; dVARS; l(2)03531; l(2)rI255; ld45671; VARS; VRS
    Summary
    Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in adult head; embryonic/larval salivary gland; and organism. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ValRS in Genome Data Viewer
    Location:
    49F7-49F7; 2-68 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13198850..13202709)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9086355..9090214)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lysine demethylase 4B Neighboring gene sequoia Neighboring gene uncharacterized protein Neighboring gene Origin recognition complex subunit 3 Neighboring gene FLICE-associated huge protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
    2. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    3. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. Huang Y, et al. PLoS One, 2015. PMID 26659849, Free PMC Article
    4. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Li S, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958650, Free PMC Article
    5. MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure. Wu Z, et al. Mol Cell, 2019 Aug 22. PMID 31378462, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Valyl-tRNA synthetase
    Names
    CG4062-PA
    CG4062-PB
    CG4062-PC
    ValRS-PA
    ValRS-PB
    ValRS-PC
    NP_001260946.1
    NP_524838.1
    NP_725259.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13198850..13202709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274017.1 → NP_001260946.1  Valyl-tRNA synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF06, T2GFI6
      Conserved Domains (5) summary
      cd07962
      Location:736 → 873
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:129 → 736
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:80 → 1053
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam10458
      Location:978 → 1053
      Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
      pfam13603
      Location:307 → 436
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

    2. NM_165970.2 → NP_725259.1  Valyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E993, T2GFI6
      Related
      FBpp0086847
      Conserved Domains (5) summary
      cd07962
      Location:730 → 867
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:129 → 730
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:80 → 1047
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam10458
      Location:972 → 1047
      Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
      pfam13603
      Location:307 → 436
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2

    3. NM_080099.3 → NP_524838.1  Valyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E993, T2GFI6
      Related
      FBpp0086848
      Conserved Domains (5) summary
      cd07962
      Location:730 → 867
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:129 → 730
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:80 → 1047
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam10458
      Location:972 → 1047
      Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
      pfam13603
      Location:307 → 436
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF06 A0A0B4KF06
    Q0E993 Q0E993
    Q960E6 Q960E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools