|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
80-1053 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1487.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 80 PGEKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPeygrASIDAPNPNG-KFVMIIPPPNVTGSLHLGHALTNAIEDAI 158
Cdd:PTZ00419 14 KKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKP----AEDAKSLNSGkKFVIVLPPPNVTGYLHIGHALTGAIQDSL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 159 TRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVA 238
Cdd:PTZ00419 90 IRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 239 FTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEG 318
Cdd:PTZ00419 170 FTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLED 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 319 SDE-EIIVATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPF-STRRLPIVCDE-FVDMAFGTGAVKITPAHDPNDYEV 395
Cdd:PTZ00419 250 SGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFiPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 396 GKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCS 475
Cdd:PTZ00419 330 AKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCK 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 476 DMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSlqtgssahgSVNDDEQYWIVA 555
Cdd:PTZ00419 410 DMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPE---------TDPSDEEPWVVA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 556 RSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFG 635
Cdd:PTZ00419 481 RSEEEALEKAKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 636 QKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPEC 715
Cdd:PTZ00419 561 LHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPEC 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 716 GSDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQM----DAWILSRLAA 791
Cdd:PTZ00419 641 GTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVESlpweDKWILHRLNV 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 792 AIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGS-EEQQTAARRTLYVCLDYGLRLLSPFMPFITEELY 870
Cdd:PTZ00419 721 AIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSdGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELY 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 871 QRLPRANP-APSICVASYP-SNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASD 948
Cdd:PTZ00419 801 QRLPNYLRkSESISIAKYPqPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAENL 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 949 LATISYCSNVVF------DSPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATK 1022
Cdd:PTZ00419 881 ISTLAKIGSVSVippieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDK 960
|
970 980 990
....*....|....*....|....*....|.
gi 442623560 1023 VPAEVQEANETKLCESRAEIERIAAAIETLK 1053
Cdd:PTZ00419 961 VPEDVRKLNDEKIDELNEEIKQLEQAIEELK 991
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
90-1053 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1228.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasidaPNPNGK-FVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRT 168
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKAD--------PDSDKEpFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 169 TLWVPGCDHAGIATQVVVEKLLwRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRA 248
Cdd:COG0525 75 TLWQPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 249 VTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVEGSDEEIIVATT 328
Cdd:COG0525 154 VREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGH----------------LWHIRYPLADGSGYIVVATT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 329 RIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFN 408
Cdd:COG0525 218 RPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILD 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 409 DDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSG 488
Cdd:COG0525 298 EDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 489 ELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHvsftdpslqtgssahgsvnDDEQYWIVARSEAEALTKAAEr 568
Cdd:COG0525 378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWY-------------------CPDGEVYVARTEPEACAKAGS- 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 569 fgvdaskIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVY 648
Cdd:COG0525 438 -------VNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVY 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 649 LHPMVRDAHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALCAYI 728
Cdd:COG0525 511 IHGLVRDEQGRKMSKSKGNVIDPLDLID-------------------------------------KYGADALRFTLAALA 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 729 TQARDINLDINRVLGYRFFCNKLWNATKFALLYFtgsEKFDTELSASAAINQM-DAWILSRLAAAIEACNTGFESYDFAA 807
Cdd:COG0525 554 SPGRDIKFDEERVEGYRNFANKLWNASRFVLMNL---EGFDPGLDPDPEELSLaDRWILSRLNKTIAEVTEALEKYRFDE 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 808 ATSACYAF-WlYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVAS 886
Cdd:COG0525 631 AAQALYDFvW-NEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGESIMLAP 709
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 887 YP-SNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFDSPAP 965
Cdd:COG0525 710 WPeADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVDEK 789
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 966 QGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIERI 1045
Cdd:COG0525 790 PEGAASAVVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKL 869
|
....*...
gi 442623560 1046 AAAIETLK 1053
Cdd:COG0525 870 EEQLARLK 877
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
24-1052 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 1198.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 24 AKQLEKERLKA-EKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAP-GEKKDLSGALPDAYSPRYVEA 101
Cdd:PLN02381 28 AKEKELKKLKAaQKEAKAKLQAQQASDGTNVPKKSEKKSRKRDVEDENPEDFIDPDTPfGQKKRLSSQMAKQYSPSAVEK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 102 QWYSWWEKEGFFTPeygrasiDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIA 181
Cdd:PLN02381 108 SWYAWWEKSGYFGA-------DAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 182 TQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGS 261
Cdd:PLN02381 181 TQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 262 IYRSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAV 341
Cdd:PLN02381 261 IYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGLGEIVVATTRIETMLGDTAIAI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 342 HPQDDRYKHLHGKFVVHPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYG-E 419
Cdd:PLN02381 341 HPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGsE 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 420 FTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGE---LKIIPEH 496
Cdd:PLN02381 421 FAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGEnkkLEFIPKQ 500
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 497 HTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTgssaHGSVNDdeqYWIVARSEAEALTKAAERFGvdASKI 576
Cdd:PLN02381 501 YLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQLKE----LGSYND---HWVVARNESDALLEASQKFP--GKKF 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 577 VLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDA 656
Cdd:PLN02381 572 ELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDA 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 657 HGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINL 736
Cdd:PLN02381 652 HGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDALRFALVSYTAQSDKINL 731
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 737 DINRVLGYRFFCNKLWNATKFALlyftgsEKFDTELSASAAINQMD-----AWILSRLAAAIEACNTGFESYDFAAATSA 811
Cdd:PLN02381 732 DILRVVGYRQWCNKLWNAVRFAM------SKLGDDYTPPATLSVETmpfscKWILSVLNKAISKTVSSLDAYEFSDAAST 805
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 812 CYAFWLYDLCDVYLECLKPIFQSGSEE---QQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPA---PSICVA 885
Cdd:PLN02381 806 VYSWWQYQFCDVFIEAIKPYFAGDNPEfasERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHtrkDSIMIS 885
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 886 SYPSNT-SWRSTKIESDVEFVQKAARIIRSARSDynLPNKVKTE---VYIVCTDSVPSEILKRYASDLATISYCSNVVF- 960
Cdd:PLN02381 886 EYPSAVeAWTNEKVEYEMDLVLSTVKCLRSLRAE--VLEKQKNErlpAFALCRNQEIAAIIKSHQLEILTLANLSSLKVl 963
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 961 ----DSPaPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLC 1036
Cdd:PLN02381 964 lsenDAP-PAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPANIQEEDARKLT 1042
|
1050
....*....|....*.
gi 442623560 1037 ESRAEIERIAAAIETL 1052
Cdd:PLN02381 1043 KLLQELEFFEKESKRL 1058
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
90-1053 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1184.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasidaPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTT 169
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD--------DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 170 LWVPGCDHAGIATQVVVEKLLwRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAV 249
Cdd:PRK05729 77 LWLPGTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 250 TEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVEGSDEEIIVATTR 329
Cdd:PRK05729 156 REVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGK----------------LWHIRYPLADGSDYLVVATTR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 330 IETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFND 409
Cdd:PRK05729 220 PETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 410 DGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGE 489
Cdd:PRK05729 300 DGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 490 LKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHvsftdpslqtgssahgsvnDDEQYWIVARSEAEALTKAAerf 569
Cdd:PRK05729 380 IKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWY-------------------DEDGEVYVGREEPEAREKAL--- 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 570 gvdaskivLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYL 649
Cdd:PRK05729 438 --------LTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYI 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 650 HPMVRDAHGRKMSKSLGNVIDPMDVirgitleglhaqlvgsnldpreIEKakagqkqdYpqgipecGSDALRFALCAYIT 729
Cdd:PRK05729 510 HGLVRDEQGRKMSKSKGNVIDPLDL----------------------IDK--------Y-------GADALRFTLAALAS 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 730 QARDINLDINRVLGYRFFCNKLWNATKFALLYFTGseKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAAT 809
Cdd:PRK05729 553 PGRDIRFDEERVEGYRNFANKLWNASRFVLMNLEG--ADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAA 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 810 SACYAFWLYDLCDVYLECLKPIFQsgsEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYPS 889
Cdd:PRK05729 631 RALYEFIWNEFCDWYLELAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEESIMLAPWPE 707
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 890 NTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVF---DSPAPQ 966
Cdd:PRK05729 708 ADEAIDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEIladDEEAPE 787
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 967 GCAILtVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIERIA 1046
Cdd:PRK05729 788 GAASA-VVGGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLK 866
|
....*..
gi 442623560 1047 AAIETLK 1053
Cdd:PRK05729 867 ERLARLK 873
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
90-1035 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1010.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasidaPNPNGK-FVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRT 168
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPD--------GNSNKPpFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 169 TLWVPGCDHAGIATQVVVEKLLWRDEKlSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRA 248
Cdd:TIGR00422 73 VLWLPGTDHAGIATQVKVEKKLGAEGK-TKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 249 VTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVE-GSDEEIIVAT 327
Cdd:TIGR00422 152 VKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGK----------------LYYIRYPLAnGSKDYLVVAT 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 328 TRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIF 407
Cdd:TIGR00422 216 TRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 408 NDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRS 487
Cdd:TIGR00422 296 DEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEE 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 488 GELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSftdpslQTGSsahgsvnddeqyWIVARSEAEALTKAAe 567
Cdd:TIGR00422 376 GEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCK------ECGE------------VYVAKEEPLPDDKTN- 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 568 rfgvDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEV 647
Cdd:TIGR00422 437 ----TGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEV 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 648 YLHPMVRDAHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALCAY 727
Cdd:TIGR00422 513 YIHGLVRDEQGRKMSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASL 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 728 ITQARDINLDINRVLGYRFFCNKLWNATKFALLyftgSEKFDTELSA-SAAINQMDAWILSRLAAAIEACNTGFESYDFA 806
Cdd:TIGR00422 556 VTPGDDINFDWKRVESARNFLNKLWNASRFVLM----NLSDDLELSGgEEKLSLADRWILSKLNRTIKEVRKALDKYRFA 631
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 807 AATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPraNPAPSICVAS 886
Cdd:TIGR00422 632 EAAKALYEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK--EGADSIMLQS 709
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 887 YPS-NTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFDSPAP 965
Cdd:TIGR00422 710 YPVvDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKP 789
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442623560 966 -QGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKL 1035
Cdd:TIGR00422 790 eVTEAVVELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKL 860
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
90-1039 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 868.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasiDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTT 169
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGD------EHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 170 LWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAV 249
Cdd:PRK14900 89 LWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 250 TEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEipgrtflsipgyedkVEFGVLIKFAYKVEGSDEEIIVATTR 329
Cdd:PRK14900 169 REVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEE---------------AHQGELWSFAYPLADGSGEIVVATTR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 330 IETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFN 408
Cdd:PRK14900 234 PETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 409 DDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETlnNPMVVPI--CSRSKDVVEPLIKPQWYVSCSDMAASATEAVR 486
Cdd:PRK14900 314 PDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGA--KPHVLPLgrCQRSATILEPLLSDQWYVRIEPLARPAIEAVE 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 487 SGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPslqtgssahgsvnddeqywIVARSEAEALTKAA 566
Cdd:PRK14900 392 QGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV-------------------TVARETPEACSTCG 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 567 ERfgvdaskiVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKE 646
Cdd:PRK14900 453 KA--------ELRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRT 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 647 VYLHPMVRDAHGRKMSKSLGNVIDPMDVirgitleglhaqlvgsnldpreiekakagqkqdypqgIPECGSDALRFALCA 726
Cdd:PRK14900 525 VYLHPMVRDEKGQKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAA 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 727 YITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKfDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFA 806
Cdd:PRK14900 568 LTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNLSGYQE-RGEDPARLARTPADRWILARLQRAVNETVEALEAFRFN 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 807 AATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLP---RANPAP-SI 882
Cdd:PRK14900 647 DAANAVYAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvGASAWAdSV 726
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 883 CVASYPSNTswrSTKIESDVEFVQKAARI--IRSARSDYNLPNKVKTE----VYIVCTDSVPSEILKR----YASDLATI 952
Cdd:PRK14900 727 LAAEYPRKG---EADEAAEAAFRPVLGIIdaVRNIRGEMGIPWKVKLGaqapVEIAVADPALRDLLQAgelaRVHRVAGV 803
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 953 SYCSNVVFDSPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANE 1032
Cdd:PRK14900 804 EGSRLVVAAATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDR 883
|
....*..
gi 442623560 1033 TKLCESR 1039
Cdd:PRK14900 884 ARAEELR 890
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
100-1055 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 767.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 100 EAQWYSWWEKEGFFTPEYGRASidapNPngkFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAG 179
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGG----DP---FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 180 IATQVVVEKLLwRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEE 259
Cdd:PLN02943 139 IATQLVVEKML-ASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEK 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 260 GSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVEG-SDEEIIVATTRIETMLGDTA 338
Cdd:PLN02943 218 GLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGT----------------LYYIKYRVAGgSEDFLTIATTRPETLFGDVA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 339 VAVHPQDDRYKHLHGKFVVHPFST-RRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIigdy 417
Cdd:PLN02943 282 IAVNPEDDRYSKYIGKMAIVPMTYgRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTL---- 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 418 GEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHH 497
Cdd:PLN02943 358 NEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 498 TKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVsftdpslqTGSsahgsvnDDEQYWIVARSEAEALTKAAERFGVDaskIV 577
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWYI--------VGK-------DCEEDYIVARSAEEALEKAREKYGKD---VE 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 578 LKQDEDVLDTWFSSGIFPFSVFGWPD-QTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDA 656
Cdd:PLN02943 500 IYQDPDVLDTWFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDS 579
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 657 HGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALcAYITQARDINL 736
Cdd:PLN02943 580 QGRKMSKTLGNVIDPLDTIK-------------------------------------EFGTDALRFTL-ALGTAGQDLNL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 737 DINRVLGYRFFCNKLWNATKFALLYFTGSE-----------KFDTElSASAAINQMDAWILSRLAAAIEACNTGFESYDF 805
Cdd:PLN02943 622 STERLTSNKAFTNKLWNAGKFVLQNLPSQSdtsawehilacKFDKE-ESLLSLPLPECWVVSKLHELIDSVTTSYDKYFF 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 806 AAATSACYAFWLYDLCDVYLECLKP-IFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPraNPAPSICV 884
Cdd:PLN02943 701 GDVGREIYDFFWSDFADWYIEASKTrLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALP--YRKEALIV 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 885 ASYPSNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASdLATISYC--SNVVFDS 962
Cdd:PLN02943 779 SPWPQTSLPKDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEV-LALLSRLdlQNVHFTD 857
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 963 PAPqGCAILTV----TGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCES 1038
Cdd:PLN02943 858 SPP-GDANQSVhlvaSEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEA 936
|
970
....*....|....*..
gi 442623560 1039 RAEIERIAAAIETLKLM 1055
Cdd:PLN02943 937 EEKIKLTKNRLAFLKST 953
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
102-737 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 662.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 102 QWYSWWEKEGFFTPEygrasIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIA 181
Cdd:pfam00133 1 QIYEFWDEQGYFKPE-----LEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 182 TQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGS 261
Cdd:pfam00133 76 TEQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 262 IYRSSRLVNWSCTLRSAISDIEVDkveipgrtflsipgYEDKVefGVLIKFAYKVEGSDE-EIIVATTRIETMLGDTAVA 340
Cdd:pfam00133 156 IYRGKKLVNWSPALNTALSNLEVE--------------YKDVK--GPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 341 VHP-------------------------------QDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHD 389
Cdd:pfam00133 220 VNPefdyvitgegyilaeallkslykkgtdkkilEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 390 PNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQ 469
Cdd:pfam00133 300 ENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQ 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 470 WYVSCSDMAASATEAVRsgELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSahgsvndde 549
Cdd:pfam00133 380 WFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGEL--------- 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 550 QYWIVARSEAEALTKAAERFGVD---ASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQ-TKDLQTFYPTSLLETGHDILF 625
Cdd:pfam00133 449 FELVAGRFEEEGSIKWLHREAKDklgYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTR 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 626 FWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqk 705
Cdd:pfam00133 529 GWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID----------------------------- 579
|
650 660 670
....*....|....*....|....*....|..
gi 442623560 706 qdypqgipECGSDALRFALCaYITQARDINLD 737
Cdd:pfam00133 580 --------KYGADALRLWLA-NSDYGRDINLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
129-736 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 615.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 129 GKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKlSRHDLGREKFIE 208
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGK-TRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 209 RIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVdkve 288
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 289 ipgrtflsipgyedkvefgvlikfaykvegsdeeiivattrietmlgdtavavhpqddrykhlhgkfvvhpfstrrlpiv 368
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 369 cdefvdmafgtgavkitpahdpndyevgkrcnlpfitifnddgyiigdygeftgmkrfecrkkileklkalnlyretlnn 448
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 449 pmvvpiCSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHV 528
Cdd:cd00817 156 ------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 529 SftdpslqtgssahgsvndDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDL 608
Cdd:cd00817 230 K------------------DGGHWVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDL 291
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 609 QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGItleglhaqlv 688
Cdd:cd00817 292 KKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY---------- 361
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 442623560 689 gsnldpreiekakagqkqdypqgipecGSDALRFALCAYITQARDINL 736
Cdd:cd00817 362 ---------------------------GADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
89-966 |
1.64e-165 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 507.04 E-value: 1.64e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 89 ALPDAYSPRYVEAQWYSWWEKEG--FFTPEYGRA--SIDAPnpngkfvmiipPPNVTGSLHLGHALTNAIEDAITRYHRM 164
Cdd:PRK13208 5 ELPKKYDPEELEEKWQKIWEEEGtyKFDPDERKPvySIDTP-----------PPTVSGSLHIGHVFSYTHTDFIARYQRM 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 165 KGRTTLWVPGCDHAGIATQVVVEKLLwrdeKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPK 244
Cdd:PRK13208 74 RGYNVFFPQGWDDNGLPTERKVEKYY----GIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 245 LCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVdkveipgrtflsipgyEDKVEFGVLIKFAYKVEGsDEEII 324
Cdd:PRK13208 150 YRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEV----------------EYREREGKLNYIKFPVED-GEEIE 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 325 VATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFI 404
Cdd:PRK13208 213 IATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 405 TIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLY--RETLNNPmvVPICSRSKDVVEPLIKPQWYVSCSDMAASAT 482
Cdd:PRK13208 293 IIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLgkQEPIKHN--VKFCERCDTPLEILVTRQWFIKVLDLKEELL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 483 EAVRsgELKIIPEHHTKTWYHWMDGIR-DWCVSRQ--------LWW----GHRIPAyhvsftdpslqtgssahgsvnDDE 549
Cdd:PRK13208 371 ERGK--EINWYPEHMRVRLENWIEGLNwDWCISRQryfgtpipVWYckdcGHPILP---------------------DEE 427
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 550 QYWIVARSEAEALTKAAERfGVDAskivLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFW-- 627
Cdd:PRK13208 428 DLPVDPTKDEPPGYKCPQC-GSPG----FEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWlf 502
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 628 --VARMVFfgqkLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIrgitleglhaqlvgsnldpreiekakagqk 705
Cdd:PRK13208 503 ytILRAYL----LTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELL------------------------------ 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 706 QDYpqgipecGSDALRFALcAYITQARDINLDINRV-LGYRFFcNKLWNATKFALLYftgseKFDTELSASAAINQMDAW 784
Cdd:PRK13208 549 EKY-------GADAVRYWA-ASARLGSDTPFDEKQVkIGRRLL-TKLWNASRFVLHF-----SADPEPDKAEVLEPLDRW 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 785 ILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKP-IFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMP 863
Cdd:PRK13208 615 ILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLP 694
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 864 FITEELYQRLPRAnpapSICVASYPS-NTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPsEIL 942
Cdd:PRK13208 695 FITEEVWSWLYGG----SVHRASWPEpDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPADL-ELL 769
|
890 900
....*....|....*....|....
gi 442623560 943 KRYASDLATISYCSNVVFDSPAPQ 966
Cdd:PRK13208 770 EAAEEDLKAAGNIEELELVEGDPE 793
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
99-967 |
3.69e-91 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 312.40 E-value: 3.69e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 99 VEAQWYSWWEKEGFFtpeygRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCD-H 177
Cdd:COG0060 21 REPEILKFWEENDIY-----EKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 178 aGIATQVVVEKLLWRDeKLSRHDLGREKFIER--------IWDWRrekggriyEQLKSLGSSYDWTRVAFTMDPKLCRAV 249
Cdd:COG0060 96 -GLPIELKVEKELGIK-KKDIEKVGIAEFREKcreyalkyVDEQR--------EDFKRLGVWGDWDNPYLTMDPEYEESI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 250 TEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVdkveipgrtflsipGYEDKVEFGVLIKF----AYKVEGSDEEIIV 325
Cdd:COG0060 166 WWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV--------------EYKDVTSPSIYVKFpvkdEKALLLLEDAYLV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 326 A-TTRIETMLGDTAVAVHPQ----------DDRY---------------------------KHLHGKFVVHPFST----- 362
Cdd:COG0060 232 IwTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFYYvvgyd 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 363 RRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALN-- 440
Cdd:COG0060 312 RAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGal 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 441 LYRETLNNPmvVPICSRSKdvvEPLI---KPQWYVSCSDMAASATEAVRsgelKI--IPEHHTKTWYHWMDGIRDWCVSR 515
Cdd:COG0060 392 LAREKITHS--YPHCWRCK---TPLIyraTPQWFISMDKLRDRALEAIE----KVnwIPEWGEGRFGNMLENRPDWCISR 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 516 QLWWGHRIPAYhvsftdpslqtgssahgsVNDDEQYWI----VARSEAEALTKAAER--FGVDASKIVL----------- 578
Cdd:COG0060 463 QRYWGVPIPIW------------------VCEDCGELHrteeVIGSVAELLEEEGADawFELDLHRPFLdetlkcpkcgg 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 579 --KQDEDVLDTWFSSGIFPFSV------FGWPdqtKDL------QT---FYpTSLLEtghdilffwvARMVFfgqkllGK 641
Cdd:COG0060 525 tmRRVPDVLDVWFDSGSMHFAVlenreeLHFP---ADFylegsdQTrgwFY-SSLLT----------STALF------GR 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 642 LPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIrgitleglhaqlvgsnldpreiekakagqKQDypqgipecGSDALR 721
Cdd:COG0060 585 APYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI-----------------------------DKY--------GADILR 627
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 722 FALcAYITQARDINLD---INRVlgYRFFcNKLWNATKFallyFTGS-EKFD--TELSASAAINQMDAWILSRLAAAIEA 795
Cdd:COG0060 628 LWV-ASSDYWGDLRFSdeiLKEV--RDVY-RRLRNTYRF----LLANlDDFDpaEDAVPYEDLPELDRWILSRLNELIKE 699
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 796 CNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQ--TAARRTLYVCLDYGLRLLSPFMPFITEELYQRL 873
Cdd:COG0060 700 VTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLdrRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNL 779
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 874 PRANPaPSICVASYPS-NTSWRSTKIESDVEFVQK----AARIIRSARSDynlpNKVK---TEVYIVCTDSVPSEILKRY 945
Cdd:COG0060 780 PGEAE-ESVHLADWPEvDEELIDEELEAKWDLVREvrsaVLKALEAARKE----KLIRqplEAAVVLYADEELAAALESL 854
|
970 980
....*....|....*....|...
gi 442623560 946 ASDLATISYCSNVVF-DSPAPQG 967
Cdd:COG0060 855 GDLLAEELNVSEVELvDDAEDLG 877
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
736-873 |
1.58e-60 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 202.79 E-value: 1.58e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 736 LDINRVLGYRFFCNKLWNATKFALLYFtgsEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAF 815
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNL---EDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 442623560 816 WLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRL 873
Cdd:cd07962 78 FWNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
100-948 |
4.93e-57 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 214.25 E-value: 4.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 100 EAQWYSWWEKEGFFTpeygraSIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAG 179
Cdd:PLN02843 9 EPEIQKLWEENQVYK------RVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 180 IATQVVVEKLLwrDEKlSRHDLG----REK---FIERIWDWRREkggriyeQLKSLGSSYDWTRVAFTMDPKLCRAVTEA 252
Cdd:PLN02843 83 LPIELKVLQSL--DQE-ARKELTpiklRAKaakFAKKTVDTQRE-------SFKRYGVWGDWENPYLTLDPEYEAAQIEV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 253 FVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEipGRTFLSI--------PGYEDKVEFGVLIKFAYkvegsdeeII 324
Cdd:PLN02843 153 FGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPE--GHVSKSIyvafpvvsPSETSPEELEEFLPGLS--------LA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 325 VATTRIETMLGDTAVAVHPQDD--------------------------RYKHLHGKFVV--------------------- 357
Cdd:PLN02843 223 IWTTTPWTMPANAAVAVNDKLQysvvevqsfsedestsggnkkkrpgnVLKEQQKLFLIvatdlvpaleakwgvklvvlk 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 358 -------------HPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGM 423
Cdd:PLN02843 303 tfpgsdlegcryiHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGL 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 424 KRF-ECRKKILEKLK-ALNLYRETLNNPMVvPICSRSKdvvEPLI---KPQWYVSCSDMAASATEAVRSgeLKIIPEHHT 498
Cdd:PLN02843 383 SVLgEGNAAVVEALDeAGSLLMEEAYGHKY-PYDWRTK---KPTIfraTEQWFASVEGFRQAALDAIDK--VKWIPAQGE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 499 KTWYHWMDGIRDWCVSRQLWWGHRIPA-YHVSFTDPSL--------QTGSSAHGSvnddEQYWIVarSEAEALtkaAERF 569
Cdd:PLN02843 457 NRIRAMVSGRSDWCISRQRTWGVPIPVfYHVETKEPLMneetiahvKSIVAQKGS----DAWWYM--DVEDLL---PEKY 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 570 GVDASKivLKQDEDVLDTWFSSGIFPFSVFGwpdQTKDLQtfYPTSLLETGHDILFFWvarmvfFGQKLL------GKLP 643
Cdd:PLN02843 528 RDKASD--YEKGTDTMDVWFDSGSSWAGVLG---SREGLS--YPADLYLEGSDQHRGW------FQSSLLtsvatkGKAP 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 644 FKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGitleglhaqlvGSNldpreiekakagQKQDypqgiPECGSDALRF- 722
Cdd:PLN02843 595 YKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG-----------GKN------------QKQE-----PAYGADVLRLw 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 723 -ALCAY----------ITQARDInldinrvlgYRffcnKLWNATKFALlyfTGSEKFDTELSAS-AAINQMDAWILSRLA 790
Cdd:PLN02843 647 vASVDYtgdvligpqiLKQMSDI---------YR----KLRGTLRYLL---GNLHDWKPDNAVPyEDLPSIDKYALFQLE 710
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 791 AAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSeeQQTAARRT----LYVCLDYGLRLLSPFMPFIT 866
Cdd:PLN02843 711 NVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGG--TTSFTRRScqtvLAAHLLSLLRAIAPILPHLA 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 867 EELYQRLP---RANPAPSICVASYPS-NTSWRSTKIEsDVEFVQK-------AARIIRSARSDYNLPNKVKTEVYIVCTD 935
Cdd:PLN02843 789 EDAWQNLPfqeDGSAAESVFEAGWPTpNEEWLSFPAE-DVDFWSLllevrdeVNKVLESARNGKLIGASLEAKVYLHASD 867
|
970
....*....|...
gi 442623560 936 SVPSEILKRYASD 948
Cdd:PLN02843 868 ASLAARLAELCGA 880
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
130-676 |
1.46e-55 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 195.33 E-value: 1.46e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 130 KFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKlsrhDLGREKFIER 209
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKK----TIWIEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 210 IWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLvnwsctlrsaisdievdkvei 289
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP--------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 290 pgrtflsipgyedkvefgvlikfaykvegsdeeiivattrietmlgdtaVAVHPQddrykhlhgkfvvhpfstrrlpivc 369
Cdd:cd00668 136 -------------------------------------------------VRITEQ------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 370 dEFVDMafgtgavkitpahdpndyevgkrcnlpfitifnddgyiigdyGEFtgmkrfecRKKILEKLKalnlyretlnnp 449
Cdd:cd00668 142 -WFFDM------------------------------------------PKF--------KEKLLKALR------------ 158
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 450 mvvpicsrskdvveplikpqwyvscsdmaasateavrsgELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPayhvs 529
Cdd:cd00668 159 ---------------------------------------RGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP----- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 530 ftdpslqtgssahgsvnddeqywivarseaealtkaaerfgvdaskivlkqdEDVLDTWFSSGIFPFSVFGWPDQTKDLQ 609
Cdd:cd00668 195 ----------------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFK 222
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623560 610 TFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIR 676
Cdd:cd00668 223 DSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE 289
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
782-931 |
4.99e-40 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 144.47 E-value: 4.99e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 782 DAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQqtAARRTLYVCLDYGLRLLSPF 861
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS--RAQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 862 MPFITEELYQRLpranpapSICVASYPSNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYI 931
Cdd:pfam08264 79 MPFITEELWQKE-------SIHLAPWPEDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
121-875 |
2.96e-39 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 158.98 E-value: 2.96e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 121 SIDAPNPNGK-------FVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrD 193
Cdd:PTZ00427 87 SIDAFNTSNKlaknkkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEK----E 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 194 EKLSRhdlgREKFIERIWDWRREKGGRIY--------EQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRS 265
Cdd:PTZ00427 163 NNINK----KEDILKMGIDVYNEKCRGIVlkysnewvKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKS 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 266 SRLVNWSCTLRSAISDIEV--------DKVEIPGRTFLS--------IPGYEDKVEFGVLIKFAY--KVEGSDE------ 321
Cdd:PTZ00427 239 FKVMPYSCKCNTPISNFELnlnykdtpDPSIIISFVLCSdfpkveeeCNIEEDKQLLGEKYSVLYnnKRENSNNgnnnst 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 322 ---------EIIVATTRIETMLGDTAVAV------------------------------------------------HPQ 344
Cdd:PTZ00427 319 nnvcyaqhsEILAWTTTPWTLPSNLALCVnehftylrihhvksnrvvivgecrlewimkelkwnvedlkivnrfkgkELK 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 345 DDRYKHLHGKFV-VHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNL--PFITIFND----DGYIIGDY 417
Cdd:PTZ00427 399 GLRYKPLFTNFYeKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIFIDpldaNGYFTNEV 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 418 GEFTGMKRFECRKKILEKLKALNlyRETLNNPMV--VPICSRSKdvvEPLIK---PQWYVSCSDmaaSATEAVRSGELKI 492
Cdd:PTZ00427 479 EEVQNLYIKEADNVIKKKLKNEN--RLLSNNTIVhsYPFCWRSD---TPLIYraiPAWFIRVSN---STNELVKNNETTY 550
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 493 -IPEH-HTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAH-------GSVNDDEQYWIvARSEAEALT 563
Cdd:PTZ00427 551 wIPAHiKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHleelsgvKNINDLHRHFI-DHIEIKNPK 629
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 564 kaaerfGVDASKivLKQDEDVLDTWFSSGIFPFSVFGWP--DQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGK 641
Cdd:PTZ00427 630 ------GKTYPK--LKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDK 701
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 642 LPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSnldpreiEKAKAGQKQDYPQGIPECgsdALR 721
Cdd:PTZ00427 702 APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINS-------VAVRAENLKFQEKGVNEV---VKS 771
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 722 FALCAYITqardinldinrvlgYRFFCNKL-----WNATKFAllyftgsekFDTELSASAAiNQMDAWILSRLAAAIEAC 796
Cdd:PTZ00427 772 FILPFYHS--------------FRFFSQEVtryecLNKKQFL---------FNTDYIYKND-NIMDQWIFSSVQSLTKSV 827
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 797 NTGFESYDFAAATSACYAFwLYDLCDVYLECLKPIFQ-SGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPR 875
Cdd:PTZ00427 828 HTEMKAYKLYNVLPKLLQF-IENLTNWYIRLNRDRMRgSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRR 906
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
94-873 |
6.65e-37 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 150.29 E-value: 6.65e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 94 YSPRYVEAQWYSWWEKEGFFTPEygrasiDAPNPNGKFVM-IIPPPnvTGSLHLGHALTNAIEDAITRYHRMKGRTTLWV 172
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVT------DDSSKPKYYILsMFPYP--SGALHMGHVRNYTITDVLSRYYRMKGYNVLHP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 173 PGCDHAGI-ATQVVVEKllwrdeklSRHDLgrekfieriwDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTE 251
Cdd:TIGR00396 73 IGWDAFGLpAENAAIKR--------GIHPA----------KWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQW 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 252 AFVRLHEEGSIYRSSRLVNWSCTL-------------RSAISDIEVDKVEIPgRTFLSIPGYEDKV-------------- 304
Cdd:TIGR00396 135 IFLELFEKGLAYVKEADVNWCPNDgtvlaneqvdsdgRSWRGDTPVEKKELK-QWFLKITAYAEELlndleeldhwpesv 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 305 ----------EFGVLIKFayKVEGSDEEIIVATTRIETMLGDTAVAV---HP-------------------------QDD 346
Cdd:TIGR00396 214 kemqrnwigkSEGVEITF--KIADHDEKITVFTTRPDTIFGVTYLALapeHPlvekaaennpkvaafikkilnktvaERT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 347 RYKHLH-----GKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITI-------------FN 408
Cdd:TIGR00396 292 KATKEKkgvdtGIKAIHPLTGEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVidpaekdlsltaaYT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 409 DDGYIIgDYGEFTGMKRFECRKKILEKLKALNLYRETLNnpmvvpicsrskdvveplikpqwyvscsdmaasateavrsg 488
Cdd:TIGR00396 372 EDGVLV-NSGEFNGLNSSEARNAIIDMLEKEGKGKRKVN----------------------------------------- 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 489 elkiipehhtktwYHwmdgIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAE- 567
Cdd:TIGR00396 410 -------------YR----LRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNv 472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 568 ---RFGVDAskivlKQDEDVLDTWFSSGIFpFSVFGWPDQT------KDLQTFYPTSLLETG--HDILFFWVARmvfFGQ 636
Cdd:TIGR00396 473 tcpSCGKPA-----LRETDTMDTFAGSSWY-YLRYLDPKNTdgpfdkEKAEYWLPVDLYIGGieHAILHLLYAR---FFH 543
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 637 KLLG-------KLPFKEVYLHPMV-----------------------RDAHGR--------KMSKSLGNVIDPMDVIRgi 678
Cdd:TIGR00396 544 KFLRdigyvntKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIVE-- 621
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 679 tleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNatkfa 758
Cdd:TIGR00396 622 -----------------------------------SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWN----- 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 759 lLYFTGSEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFE-SYDFAAATSACYAF----WLYDLCDVYLECLKPIfq 833
Cdd:TIGR00396 662 -LVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEkRESFNTAISAMMELlnklYKAKKEALMLEYLKGF-- 738
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 442623560 834 sgseeqqtaarrtlyvcldygLRLLSPFMPFITEELYQRL 873
Cdd:TIGR00396 739 ---------------------VTVLSPFAPHLAEELWEKL 757
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
137-924 |
1.53e-36 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 149.88 E-value: 1.53e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 137 PPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLL---WRDEKLsrhDLGREKFIER---- 209
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLgikRRDDVL---KMGIDKYNEEcrsi 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 210 ----IWDWrrEKggriyeQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVd 285
Cdd:PLN02882 123 vtrySKEW--EK------TVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 286 kveipGRTFLSIPGYEDKVEFGVlikfaykVEGSDEEIIVA-TTRIETMLGDTAVAVHPQ-------------------- 344
Cdd:PLN02882 194 -----GLNYKDVSDPAVMVSFPI-------VGDPDNASFVAwTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaes 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 345 -------------------------------------DDRYKHLHGKFVvhPFSTRRLPIVCDEFVDMAFGTGAVKITPA 387
Cdd:PLN02882 262 rlsalptakpkskkgskpenaaegyevlakvpgsslvGKKYEPLFDYFS--EFSDTAFRVVADDYVTDDSGTGVVHCAPA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 388 HDPNDYEV-------GKRCNLPfiTIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKd 460
Cdd:PLN02882 340 FGEDDYRVclangiiEKGGNLP--VPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSD- 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 461 vvEPLIK---PQWYVSCSDMAASATEavRSGELKIIPEH-HTKTWYHWMDGIRDWCVSRQLWWGHRIPAYhvsftdpslq 536
Cdd:PLN02882 417 --TPLIYravPSWFVKVEEIKDRLLE--NNKQTYWVPDYvKEKRFHNWLENARDWAVSRSRFWGTPLPIW---------- 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 537 tgssahgsVNDDEQYWIVARS--EAEALT--KAAE--RFGVDASKI---------VLKQDEDVLDTWFSSGIFPFSVFGW 601
Cdd:PLN02882 483 --------ISDDGEEVVVIGSiaELEKLSgvKVTDlhRHFIDHITIpssrgpefgVLRRVDDVFDCWFESGSMPYAYIHY 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 602 PDQTKDL-QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITL 680
Cdd:PLN02882 555 PFENKELfEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 681 EGLHAQLVGSnldpreiekakagqkqdypqgiPECGSDALRFALCAYITQARDINLDINRvlGYRFFcnkLWNATKFALl 760
Cdd:PLN02882 635 DALRLYLINS----------------------PVVRAEPLRFKEEGVFGVVKDVFLPWYN--AYRFL---VQNAKRLEV- 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 761 yfTGSEKFDTELSAS--AAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFwLYDLCDVYLEC----LKPifQS 834
Cdd:PLN02882 687 --EGGAPFVPLDLAKlqNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTNIYVRFnrkrLKG--RT 761
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 835 GSEEQQTAArRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPA--PSICVASYPS-NTSWRSTKIESDVEFVQKAARI 911
Cdd:PLN02882 762 GEEDCRTAL-STLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGseESIHYCSFPQvDEGELDERIEQSVSRMQTVIEL 840
|
890
....*....|...
gi 442623560 912 IRSARSDYNLPNK 924
Cdd:PLN02882 841 ARNIRERHNKPLK 853
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
91-888 |
1.76e-35 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 145.58 E-value: 1.76e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 91 PDAYSPRYVEAQWYSWWEKEGFFtpeygRASIDAPNPngKF---VMIiPPPnvTGSLHLGHALTNAIEDAITRYHRMKGR 167
Cdd:COG0495 2 QERYNPKEIEKKWQKYWEENGTF-----KADEDSSKP--KYyvlDMF-PYP--SGRLHMGHVRNYTIGDVVARYKRMQGY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 168 TTL----WvpgcD-------HAGIATQVvvekllwrdeklsrHdlgrekfiERIWDW------RRekggriyeQLKSLGS 230
Cdd:COG0495 72 NVLhpmgW----DafglpaeNAAIKNGV--------------H--------PAEWTYenianmRR--------QLKRLGL 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 231 SYDWTRVAFTMDP-------KLcravteaFVRLHEEGSIYRSSRLVNW--SC--TL--------RSAISDIEVDKVEIPG 291
Cdd:COG0495 118 SYDWSREIATCDPeyykwtqWI-------FLQLYEKGLAYRKEAPVNWcpVDqtVLaneqvidgRCWRCGAPVEKKELPQ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 292 rTFLSI--------------PGYEDKV----------EFGVLIKFayKVEGSDEEIIVATTRIETMLGDTAVAV---HP- 343
Cdd:COG0495 191 -WFLKItdyadellddldklDGWPEKVktmqrnwigrSEGAEVDF--PVEGSDEKITVFTTRPDTLFGATFMVLapeHPl 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 344 -----------------------------QDDRYKH--LHGKFVVHPFSTRRLPI-VCDeFVDMAFGTGAVKITPAHDPN 391
Cdd:COG0495 268 vkelatpeqnaavaafieeakkkseiertSETKEKTgvFTGLYAINPLTGEKIPIwIAD-YVLMDYGTGAVMAVPAHDQR 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 392 DYEVGKRCNLPFITI---------------FNDDGYIIgDYGEFTGMKRFECRKKILEKLKALNLYRETLNnpmvvpics 456
Cdd:COG0495 347 DFEFAKKYGLPIKQViapedgddpdileeaYTGDGVLI-NSGEFDGLDSEEAKEAIIEWLEEKGLGKRKVN--------- 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 457 rskdvveplikpqwyvscsdmaasateavrsgelkiipehhtktwYHwmdgIRDWCVSRQLWWGHRIPAYHvsftDPSlq 536
Cdd:COG0495 417 ---------------------------------------------YR----LRDWLISRQRYWGEPIPIIH----CED-- 441
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 537 tgssaHGSVN-----------DDEQYWIVARSeaeALTKAAE-------RFGVDAskivlKQDEDVLDTWF-SSGIF--- 594
Cdd:COG0495 442 -----CGVVPvpedqlpvelpEDVDFDPTGGS---PLARAPEwvnvtcpKCGGPA-----RRETDTMDTFVdSSWYYlry 508
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 595 --------PFSvfgwPDQTK-----DLqtfYptslleTG---HDILFFWVARmvFFgQKLL---GKLPFKEvylhP---- 651
Cdd:COG0495 509 tdphndeaPFD----PEAANywlpvDQ---Y------IGgieHAILHLLYAR--FF-TKVLrdlGLVSFDE----Pfkrl 568
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 652 ----MVRD--------AHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqDYpqgipecGSDA 719
Cdd:COG0495 569 ltqgMVLEvgkdgvviGGIEKMSKSKGNVVDPDEIIE------------------------------KY-------GADT 611
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 720 LRFalcaYITQA----RDINLDINRVLG-YRFFcNKLWNatkfalLYFTGSEKFDTELSASAAinqMDAWILSRLAAAIE 794
Cdd:COG0495 612 LRL----FEMFAgppeRDLEWSDSGVEGaYRFL-NRVWR------LVVDEAEALKLDVADLSE---ADKELRRALHKTIK 677
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 795 ACNTGFESYDFAAATSACYAF--WLYDLCDvyleclkpifqsgSEEQQTAARRTLYVCLdygLRLLSPFMPFITEELYQR 872
Cdd:COG0495 678 KVTEDIERLRFNTAIAALMELvnALYKAKD-------------SGEADRAVLREALETL---VLLLAPFAPHIAEELWER 741
|
970
....*....|....*.
gi 442623560 873 LpraNPAPSICVASYP 888
Cdd:COG0495 742 L---GHEGSVADAPWP 754
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
144-943 |
2.00e-30 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 129.99 E-value: 2.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 144 LHLGHALTNAIEDAITRYHRMKGRTTLWvPGCDHA------GIAtqvvvEKLLWRDEKL-----SRHDLGRE---KFI-- 207
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PMAFHVtgtpilGIA-----ERIARGDPETielykSLYGIPEEeleKFKdp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 208 ERIWDWRREKggrIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWsCTlrsaisdievdKV 287
Cdd:PRK12300 75 EYIVEYFSEE---AKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRY-CP-----------ND 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 288 EIP-GRTflSIPGYEDK--VEFgVLIKFAykvEGSDEEIIVATTRIETMLGDTAVAVHP--------------------- 343
Cdd:PRK12300 140 NNPvGDH--DLLDGEEPeiVEY-TLIKFE---ESEDLILPAATLRPETIFGVTNLWVNPdatyvkaevdgekwivskeaa 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 344 -----QDDRYK--------HLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDY----EVGKRCNL----- 401
Cdd:PRK12300 214 eklsfQDRDVEiieeikgsELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldvie 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 402 --PFITI-----F--------------NDD----------------GYIIGDYGEFTGMKRFECRKKILEKLKALNLYRE 444
Cdd:PRK12300 294 piPLIEVegygeFpakevveklgiksqEDPeleeatkevyraefhkGVLKENTGEYAGKPVREAREKITKDLIEKGIADI 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 445 --TLNNPMVVPICSrSKDVVEpLIKPQWYVSCSDMA--ASATEAVrsGELKIIPEHhTKTWYH----WMDgirDWCVSRQ 516
Cdd:PRK12300 374 myEFSNRPVYCRCG-TECVVK-VVKDQWFIDYSDPEwkELAHKAL--DNMEIIPEE-YRKEFEntidWLK---DRACARR 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 517 LWWGHRIPAyhvsftdpslqtgssahgsvnDDEqyWIVarseaEALT------------KAAERFGVDASKIvlkqDEDV 584
Cdd:PRK12300 446 RGLGTRLPW---------------------DEE--WII-----ESLSdstiymayytiaHKIREYGIKPEQL----TPEF 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 585 LDTWF-----------SSGIFPfsvfgwpDQTKDLQT----FYPTSLLETGHD-----ILFF------------WVARMV 632
Cdd:PRK12300 494 FDYVFlgkgdpeevskKTGIPK-------EILEEMREeflyWYPVDWRHSGKDlipnhLTFFifnhvaifpeekWPRGIV 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 633 FFGQKLLGklpfkevylhpmvrdahGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgi 712
Cdd:PRK12300 567 VNGFVLLE-----------------GKKMSKSKGNVIPLRKAIE------------------------------------ 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 713 pECGSDALRFAL--CAYITQarDINLDINRVLGYRFFCNKLWNatkFAL-LYFTGSEKFDTELsasaainqmDAWILSRL 789
Cdd:PRK12300 594 -EYGADVVRLYLtsSAELLQ--DADWREKEVESVRRQLERFYE---LAKeLIEIGGEEELRFI---------DKWLLSRL 658
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 790 AAAIEACNTGFESYDF-AAATSACYAfwLYDLCDVYLEclkpifqSGSEEQQTAARRTLyvclDYGLRLLSPFMPFITEE 868
Cdd:PRK12300 659 NRIIKETTEAMESFQTrDAVQEAFYE--LLNDLRWYLR-------RVGEANNKVLREVL----EIWIRLLAPFTPHLAEE 725
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623560 869 LYQRLPRANPapsICVASYPS-NTSWRSTKIESDVEFVQkaaRIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILK 943
Cdd:PRK12300 726 LWHKLGGEGF---VSLEKWPEpDESKIDEEAELAEEYVK---RLIEDIREILKVAKIKPKKVYIYVAPDWKYEVLE 795
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
137-675 |
1.11e-29 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 121.19 E-value: 1.11e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 137 PPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIER------- 209
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAKcrefalr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 210 -IWDWRrekggriyEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWsctlrsaisdievdkve 288
Cdd:cd00818 89 yVDEQE--------EQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 289 ipgrtflsipgyedkvefgvlikfaykvegsdeeiivattrietmlgdtavavhpqddrykhlhgkfvvhpfstrrlPIv 368
Cdd:cd00818 144 -----------------------------------------------------------------------------PL- 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 369 cdefvdmafgtgavkitpahdpndyevgkrcnlpfitifnddgyiigdygeftgmkrfecrkkileklkalnLYRETlnn 448
Cdd:cd00818 146 ------------------------------------------------------------------------IYRAT--- 150
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 449 pmvvpicsrskdvveplikPQWYVSCSDMAASATEAVRsgELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPayhv 528
Cdd:cd00818 151 -------------------PQWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIP---- 205
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 529 sftdpslqtgssahgsvnddeqywiVARSEaealtkaaerfgvDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDL 608
Cdd:cd00818 206 -------------------------VWYCE-------------DCGEVLVRRVPDVLDVWFDSGSMPYAQLHYPFENEDF 247
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623560 609 QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVI 675
Cdd:cd00818 248 EELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
65-440 |
3.74e-27 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 119.54 E-value: 3.74e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 65 TKEVKEAAVYTAQTAPGEKKDLSGALPDAYSPRYVEAQWYSWWEK-EGFFTPEygraSIDAPNPNgKFVM-IIPPPNVTG 142
Cdd:PLN02563 51 SRSLTRRAFAAPSALTSTTAKTTPAAKRAYPFHEIEPKWQRYWEEnRTFRTPD----DVDTSKPK-FYVLdMFPYPSGAG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 143 sLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGI-ATQVVVEKllwrdeklSRHDlgREKFIERIwdwrrekgGRI 221
Cdd:PLN02563 126 -LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLpAEQYAIET--------GTHP--KITTLKNI--------ARF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 222 YEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDK----------VEIPG 291
Cdd:PLN02563 187 RSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglsergghpvIRKPM 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 292 RTF-LSIPGYEDK-----------------------------VEFGVLikfAYKVEGSDEEIIVATTRIETMLGDTAVAV 341
Cdd:PLN02563 267 RQWmLKITAYADRlledlddldwpesikemqrnwigrsegaeLDFSVL---DGEGKERDEKITVYTTRPDTLFGATYLVV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 342 HPQ---------DDRYKHLH--------------------------GKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITP 386
Cdd:PLN02563 344 APEhpllsslttAEQKEAVEeyvdaasrksdlertelqkektgvftGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVP 423
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442623560 387 AHDPNDYEVGKRCNLPFITI--------------FNDDGYIIG---DYGEFTGMKRFECRKKILEKLKALN 440
Cdd:PLN02563 424 AHDTRDFEFAQKFDLPIKWVvkpadgneddaekaYTGEGVIVNsssSGLDINGLSSKEAAKKVIEWLEETG 494
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
745-916 |
4.50e-23 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 97.62 E-value: 4.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 745 RFFCNKLWNATKFALLY-----FTGSEKFDTELSAsaaiNQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLyD 819
Cdd:cd07961 11 RKVLLPLWNAYRFFVTYanldgFDPGKDDDAVASL----NVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFID-E 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 820 LCDVYLECLKPIF-QSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANP--APSICVASYPS-NTSWRS 895
Cdd:cd07961 86 LTNWYIRRNRKRFwGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGdaPESVHLLDWPEvDESLID 165
|
170 180
....*....|....*....|.
gi 442623560 896 TKIESDVEFVQKaarIIRSAR 916
Cdd:cd07961 166 EELEEAMELVRE---IVELGR 183
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
307-436 |
4.06e-17 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 80.28 E-value: 4.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 307 GVLIKFayKVEGSDEEIIVATTRIETMLGDTAVAV---HP---------------------QDDRYKHLH---------G 353
Cdd:pfam13603 9 GAEITF--PVEGTDEKIEVFTTRPDTLMGVTFVALapeHPlveklaeknpevaafieecknTSEIERTSEtkekegvftG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 354 KFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFI-TIFNDDGYIIGDY--------------G 418
Cdd:pfam13603 87 LYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKpVIQPEDGDLDLDImteayteegilvnsG 166
|
170
....*....|....*...
gi 442623560 419 EFTGMKRFECRKKILEKL 436
Cdd:pfam13603 167 EFDGLDSEEAKEAIIKKL 184
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
506-873 |
3.23e-16 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 83.24 E-value: 3.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 506 DGIRDWCVSRQLWWGHRIPayhvsftdpslqtgssahgsvNDDEQY---WIvarseaEALT-------KAAERFGVDASk 575
Cdd:COG0143 221 EGLQDLSISRDFDWGIPVP---------------------GDPGKVfyvWF------DALIgyisatkGYADDRGLPED- 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 576 ivlkqdedvLDTWfssgifpfsvfgWPDQTKDLQTFYptslletGHDILFF----WVArMvffgqkLLG---KLPfKEVY 648
Cdd:COG0143 273 ---------FEKY------------WPAPDTELVHFI-------GKDIIRFhaiiWPA-M------LMAaglPLP-KKVF 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 649 lhpmvrdAH------GRKMSKSLGNVIDPMDVIrgitleglhaqlvgsnldpreiekakagqkQDYpqgipecGSDALRF 722
Cdd:COG0143 317 -------AHgfltveGEKMSKSRGNVIDPDDLL------------------------------DRY-------GPDALRY 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 723 ALCAYITQARDINLD-------------------INRVLGyrfFCNKlwnatkfallyftgseKFDTELSASAAINQMDA 783
Cdd:COG0143 353 YLLREVPFGQDGDFSwedfvarvnsdlandlgnlASRTLS---MIHK----------------YFDGKVPEPGELTEADE 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 784 WILSRLAAAIEACNTGFESYDFAAATSACYAFWlyDLCDVYLECLKPIFQSgSEEQQTAARRTLYVCLdYGLR----LLS 859
Cdd:COG0143 414 ELLAEAEAALEEVAEAMEAFEFRKALEEIMALA--RAANKYIDETAPWKLA-KDEDPERLATVLYTLL-EALRilaiLLK 489
|
410
....*....|....
gi 442623560 860 PFMPFITEELYQRL 873
Cdd:COG0143 490 PFLPETAEKILEQL 503
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
130-271 |
2.79e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 74.98 E-value: 2.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 130 KFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAG-----IAtqvvvekllwrdEKLSRHDLgre 204
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGlpaenAA------------IKIGRDPE--- 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623560 205 kfieriwDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNW 271
Cdd:cd00812 66 -------DWTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
744-920 |
1.17e-13 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 70.25 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 744 YRffcnKLWNATKFAL--LY-FtgseKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDL 820
Cdd:cd07960 13 YR----KIRNTFRFLLgnLNdF----DPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 821 CDVYLE-------CLKPifqsGSEEQQtAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYPS-NTS 892
Cdd:cd07960 85 SAFYLDiikdrlyCDAK----DSLERR-SAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFLEDWPElPEE 159
|
170 180
....*....|....*....|....*...
gi 442623560 893 WRSTKIESDVEfvqkaarIIRSARSDYN 920
Cdd:cd07960 160 WKDEELEEKWE-------KLLALRDEVN 180
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
138-266 |
2.79e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 63.46 E-value: 2.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 138 PNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrdeklsrHDLGREKFIERIWDwrrek 217
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK----------EGITPEELVDRYHE----- 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 442623560 218 ggRIYEQLKSLGSSYD-WTRvafTMDPKLCRAVTEAFVRLHEEGSIYRSS 266
Cdd:pfam09334 73 --IHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKE 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
130-266 |
2.48e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.05 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 130 KFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGiatqvvvEKLLWRDEKlsrhdLGREKFier 209
Cdd:PRK11893 2 KFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHG-------QKIQRKAEE-----AGISPQ--- 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 442623560 210 iwDWRREKGGRIYEQLKSLGSSYD-WTRvafTMDPKLCRAVTEAFVRLHEEGSIYRSS 266
Cdd:PRK11893 67 --ELADRNSAAFKRLWEALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGK 119
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
620-873 |
4.49e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 60.28 E-value: 4.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 620 GHDILFF----WVArmvfFGQKLLGKLPfKEVYLHP-MVRDahGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldp 694
Cdd:PRK11893 261 GKDILRFhavyWPA----FLMAAGLPLP-KRVFAHGfLTLD--GEKMSKSLGNVIDPFDLVD------------------ 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 695 reiekakagqkqdypqgipECGSDALR--FALCAYITQARDINLD-----INRVLGYRFfcNKLWNAT-KFALLYFTGSE 766
Cdd:PRK11893 316 -------------------EYGVDAVRyfLLREIPFGQDGDFSREafinrINADLANDL--GNLAQRTlSMIAKNFDGKV 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 767 KFDTELSASaainqmDAWILSRLAAAIEACNTGFESYDFAAatsACYAFW-LYDLCDVYLECLKP--IFQSGSEEQQTaa 843
Cdd:PRK11893 375 PEPGALTEA------DEALLEAAAALLERVRAAMDNLAFDK---ALEAILaLVRAANKYIDEQAPwsLAKTDPERLAT-- 443
|
250 260 270
....*....|....*....|....*....|....
gi 442623560 844 rrTLYVCLDYgLR----LLSPFMPFITEELYQRL 873
Cdd:PRK11893 444 --VLYTLLEV-LRgiavLLQPVMPELAAKILDQL 474
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
138-263 |
5.55e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.08 E-value: 5.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 138 PNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrdEKLSRHDLGRE--KFIERIWDWrr 215
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEE-----EGVTPQELCDKyhEIFKDLFKW-- 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 442623560 216 ekggriyeqlksLGSSYD-WTRvafTMDPKLCRAVTEAFVRLHEEGSIY 263
Cdd:cd00814 82 ------------LNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIY 115
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
739-862 |
1.03e-08 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 54.43 E-value: 1.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 739 NRVLGYRFFCNKLWNATKFALLYFTG-SEKFDTELsasaaINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWL 817
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGtQPKWDNEL-----LEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTN 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 442623560 818 YDlcDVYLECLKPIFQSgsEEQQTAARRTLYVCLDYGLRLLSPFM 862
Cdd:cd07375 77 EL--NWYLDELKPALQT--EELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
731-873 |
1.09e-06 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 48.64 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 731 ARDI-NLdINRVLGyrfFCNKlwnatkfallyftgseKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAAT 809
Cdd:cd07957 6 ANNLgNL-VNRTLN---MASK----------------YFGGVVPEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKAL 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623560 810 SAcyAFWLYDLCDVYLECLKPiFQSGSEEQQTAARRTLYVCLdYGLR----LLSPFMPFITEELYQRL 873
Cdd:cd07957 66 EE--IMELARAANKYIDETAP-WKLAKEEDPERLATVLYVLL-ELLRilaiLLSPFMPETAEKILDQL 129
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
600-873 |
1.78e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 52.11 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 600 GWPDQTKDL-QTFYPTSLLETGHDIL-F---FWVArMVffgqKLLG-KLPfKEVYlhpmvrdAHG------RKMSKSLGN 667
Cdd:PRK12267 240 GYGSDDDELfKKFWPADVHLVGKDILrFhaiYWPI-ML----MALGlPLP-KKVF-------AHGwwlmkdGKMSKSKGN 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 668 VIDPMDVIrgitleglhaqlvgsnldpreiekakagqkQDYpqgipecGSDALRFALCAYITQARD-----------INL 736
Cdd:PRK12267 307 VVDPEELV------------------------------DRY-------GLDALRYYLLREVPFGSDgdfspealverINS 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 737 DINrvlgyrffcNKLWNatkfaLLYFTGS--EK-FDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSacy 813
Cdd:PRK12267 350 DLA---------NDLGN-----LLNRTVAmiNKyFDGEIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALE--- 412
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623560 814 AFW-LYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDyGLR----LLSPFMPFITEELYQRL 873
Cdd:PRK12267 413 EVWkLISRANKYIDETAPWVLAKDEGKKERLATVMYHLAE-SLRkvavLLSPFMPETSKKIFEQL 476
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
466-675 |
9.11e-06 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 48.78 E-value: 9.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 466 IKPQWYV--SCSDMAASATEAVRsgELKIIPEHHTKTWYHWMDgirdwcVSRQLWWGHRIPayhVSFTDPSLqTGSS--- 540
Cdd:cd00812 128 LLDQWFLkySETEWKEKLLKDLE--KLDGWPEEVRAMQENWIG------CSRQRYWGTPIP---WTDTMESL-SDSTwyy 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 541 -----AHGSVNDDEQYWIVARSEAEALTKaaerfgVDaskivlkqdedvldtWFSSGifpfsvfgwpdqtKDLQ----TF 611
Cdd:cd00812 196 arytdAHNLEQPYEGDLEFDREEFEYWYP------VD---------------IYIGG-------------KEHApnhlLY 241
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442623560 612 YptslletghdiLFFWVArmvFFGQKLLGKLPFKEVYLHPMVRdAHGRKMSKSLGNVIDPMDVI 675
Cdd:cd00812 242 S-----------RFNHKA---LFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
140-263 |
1.02e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.41 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 140 VTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGiatqvvvEKllwrdeklsrhdlgrekfIERIwdwRREKG- 218
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG-------QK------------------IQQA---AEKAGk 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 442623560 219 ----------GRIYEQLKSLGSSYDwtrvAF--TMDPKLCRAVTEAFVRLHEEGSIY 263
Cdd:PRK12267 67 tpqeyvdeisAGFKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIY 119
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
99-170 |
3.94e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 47.76 E-value: 3.94e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442623560 99 VEAQWYSWWEKEGFFTPEYGRasiDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTL 170
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAEAGD---EPPKPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
978-1053 |
7.28e-05 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 41.87 E-value: 7.28e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623560 978 EVHLLLKGLVEADKEIAKLQKKsdqlvqtvgkltqaIQAADYATKVPAEVQEANETKLCESRAEIERIAAAIETLK 1053
Cdd:pfam10458 5 ERARLEKELAKLQKEIERVQGK--------------LANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
782-873 |
7.66e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 43.35 E-value: 7.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 782 DAWILSRLAAAIEACNTGFESYDFAAATSACYaFWLYDLCDVYLEclkpifqSGSEEqqtAARRTLYVCLDYGLRLLSPF 861
Cdd:cd07959 37 DRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLDWYRE-------RGGAG---MNKDLLRRFIEVWTRLLAPF 105
|
90
....*....|..
gi 442623560 862 MPFITEELYQRL 873
Cdd:cd07959 106 APHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
744-873 |
6.13e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 40.67 E-value: 6.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 744 YRFFcNKLWNatkfallYFTGSEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAF--WLYDLc 821
Cdd:cd07958 10 YRFL-NRVWR-------LVTELAEALAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELvnALYKY- 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 442623560 822 DVYLECLKPIFQSGSEeqqtaarrTLyvcldygLRLLSPFMPFITEELYQRL 873
Cdd:cd07958 81 KKKDAQHAAVLREALE--------TL-------VLLLAPFAPHIAEELWEEL 117
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
133-214 |
1.32e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 40.16 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 133 MIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGiatqvvvEKLLWRD-EKLSRHDLGREKFIERI- 210
Cdd:cd00802 1 TTFSGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAG-------GLIGDPAnKKGENAKAFVERWIERIk 73
|
....*.
gi 442623560 211 --WDWR 214
Cdd:cd00802 74 edVEYM 79
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
138-264 |
2.09e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 42.06 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 138 PNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrdEKLSrhdlgREKFIERIWdwrrek 217
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEK-----EGIT-----PEELIARYH------ 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 442623560 218 gGRIYEQLKSLGSSYD-WTRvafTMDPkLCRAVTEAFVR-LHEEGSIYR 264
Cdd:PRK00133 75 -AEHKRDFAGFGISFDnYGS---THSE-ENRELAQEIYLkLKENGYIYE 118
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
547-676 |
3.53e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 41.24 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623560 547 DDEQYWIVARSEAEALTKAAERFGVDaskiVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTF----YPTSLLETGHD 622
Cdd:PLN02224 255 NEVQSWIKSGLRDFSISRALVDWGIP----VPDDDKQTIYVWFDALLGYISALTEDNKQQNLETAvsfgWPASLHLIGKD 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 442623560 623 ILFF----WVARMVFFGQKLlGKLPFKEVYLhpmVRDahGRKMSKSLGNVIDPMDVIR 676
Cdd:PLN02224 331 ILRFhavyWPAMLMSAGLEL-PKMVFGHGFL---TKD--GMKMGKSLGNTLEPFELVQ 382
|
|
| |
