|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
80-1047 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1488.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 80 PGEKKDLSGALPDAYSPRYVEAQWYSWWEKEGFFTPeygrASIDAPNPNG-KFVMIIPPPNVTGSLHLGHALTNAIEDAI 158
Cdd:PTZ00419 14 KKNKKRNISSMAASYDPKEVESGWYEWWEKSGFFKP----AEDAKSLNSGkKFVIVLPPPNVTGYLHIGHALTGAIQDSL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 159 TRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVA 238
Cdd:PTZ00419 90 IRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 239 FTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEG 318
Cdd:PTZ00419 170 FTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLED 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 319 SDE-EIIVATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPF-STRRLPIVCDE-FVDMAFGTGAVKITPAHDPNDYEV 395
Cdd:PTZ00419 250 SGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFiPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 396 GKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCS 475
Cdd:PTZ00419 330 AKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCK 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 476 DMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSlqtGSNDDEQYWIVARSEAEA 555
Cdd:PTZ00419 410 DMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPE---TDPSDEEPWVVARSEEEA 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 556 LTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGK 635
Cdd:PTZ00419 487 LEKAKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDK 566
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 636 LPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALR 715
Cdd:PTZ00419 567 LPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALR 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 716 FALCAYITQARDINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQM----DAWILSRLAAAIEACN 791
Cdd:PTZ00419 647 FGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNVESlpweDKWILHRLNVAIKEVT 726
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 792 TGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGS-EEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRA 870
Cdd:PTZ00419 727 EGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSdGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNY 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 871 NP-APSICVASYP-SNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISY 948
Cdd:PTZ00419 807 LRkSESISIAKYPqPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAENLISTLAK 886
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 949 CSNVVF------DSPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQ 1022
Cdd:PTZ00419 887 IGSVSVippieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVR 966
|
970 980
....*....|....*....|....*
gi 24653289 1023 EANETKLCESRAEIERIAAAIETLK 1047
Cdd:PTZ00419 967 KLNDEKIDELNEEIKQLEQAIEELK 991
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
90-1047 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1230.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasidaPNPNGK-FVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRT 168
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKAD--------PDSDKEpFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 169 TLWVPGCDHAGIATQVVVEKLLwRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRA 248
Cdd:COG0525 75 TLWQPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 249 VTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVEGSDEEIIVATT 328
Cdd:COG0525 154 VREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGH----------------LWHIRYPLADGSGYIVVATT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 329 RIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFN 408
Cdd:COG0525 218 RPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILD 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 409 DDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSG 488
Cdd:COG0525 298 EDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 489 ELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHvsftdpslqtgsnDDEQYWIVARSEAEALTKAAErfgvdas 568
Cdd:COG0525 378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWY-------------CPDGEVYVARTEPEACAKAGS------- 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 569 kIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVR 648
Cdd:COG0525 438 -VNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVR 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 649 DAHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALCAYITQARDI 728
Cdd:COG0525 517 DEQGRKMSKSKGNVIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDI 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 729 NLDINRVLGYRFFCNKLWNATKFALLYFtgsEKFDTELSASAAINQM-DAWILSRLAAAIEACNTGFESYDFAAATSACY 807
Cdd:COG0525 560 KFDEERVEGYRNFANKLWNASRFVLMNL---EGFDPGLDPDPEELSLaDRWILSRLNKTIAEVTEALEKYRFDEAAQALY 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 808 AF-WlYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYP-SNT 885
Cdd:COG0525 637 DFvW-NEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGESIMLAPWPeADE 715
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 886 SWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFDSPAPQGCAIL 965
Cdd:COG0525 716 ELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVDEKPEGAAS 795
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 966 TVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIERIAAAIET 1045
Cdd:COG0525 796 AVVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLAR 875
|
..
gi 24653289 1046 LK 1047
Cdd:COG0525 876 LK 877
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
24-1046 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 1200.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 24 AKQLEKERLKA-EKLAKLQAKLDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAP-GEKKDLSGALPDAYSPRYVEA 101
Cdd:PLN02381 28 AKEKELKKLKAaQKEAKAKLQAQQASDGTNVPKKSEKKSRKRDVEDENPEDFIDPDTPfGQKKRLSSQMAKQYSPSAVEK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 102 QWYSWWEKEGFFTPeygrasiDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIA 181
Cdd:PLN02381 108 SWYAWWEKSGYFGA-------DAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 182 TQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGS 261
Cdd:PLN02381 181 TQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 262 IYRSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEGSDEEIIVATTRIETMLGDTAVAV 341
Cdd:PLN02381 261 IYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGLGEIVVATTRIETMLGDTAIAI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 342 HPQDDRYKHLHGKFVVHPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYG-E 419
Cdd:PLN02381 341 HPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGsE 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 420 FTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGE---LKIIPEH 496
Cdd:PLN02381 421 FAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGEnkkLEFIPKQ 500
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 497 HTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQT-GSNDDeqYWIVARSEAEALTKAAERFGvdASKIVLKQD 575
Cdd:PLN02381 501 YLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQLKElGSYND--HWVVARNESDALLEASQKFP--GKKFELSQD 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 576 EDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKM 655
Cdd:PLN02381 577 PDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKM 656
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 656 SKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDINRV 735
Cdd:PLN02381 657 SKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDALRFALVSYTAQSDKINLDILRV 736
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 736 LGYRFFCNKLWNATKFALlyftgsEKFDTELSASAAINQMD-----AWILSRLAAAIEACNTGFESYDFAAATSACYAFW 810
Cdd:PLN02381 737 VGYRQWCNKLWNAVRFAM------SKLGDDYTPPATLSVETmpfscKWILSVLNKAISKTVSSLDAYEFSDAASTVYSWW 810
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 811 LYDLCDVYLECLKPIFQSGSEE---QQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPA---PSICVASYPSN 884
Cdd:PLN02381 811 QYQFCDVFIEAIKPYFAGDNPEfasERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQPKDHtrkDSIMISEYPSA 890
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 885 T-SWRSTKIESDVEFVQKAARIIRSARSDynLPNKVKTE---VYIVCTDSVPSEILKRYASDLATISYCSNVVF-----D 955
Cdd:PLN02381 891 VeAWTNEKVEYEMDLVLSTVKCLRSLRAE--VLEKQKNErlpAFALCRNQEIAAIIKSHQLEILTLANLSSLKVllsenD 968
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 956 SPaPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAE 1035
Cdd:PLN02381 969 AP-PAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPANIQEEDARKLTKLLQE 1047
|
1050
....*....|.
gi 24653289 1036 IERIAAAIETL 1046
Cdd:PLN02381 1048 LEFFEKESKRL 1058
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
90-1047 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1185.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasidaPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTT 169
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD--------DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 170 LWVPGCDHAGIATQVVVEKLLwRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAV 249
Cdd:PRK05729 77 LWLPGTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 250 TEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVEGSDEEIIVATTR 329
Cdd:PRK05729 156 REVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGK----------------LWHIRYPLADGSDYLVVATTR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 330 IETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFND 409
Cdd:PRK05729 220 PETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 410 DGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGE 489
Cdd:PRK05729 300 DGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 490 LKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHvsftdpslqtgsnDDEQYWIVARSEAEALTKAAerfgvdask 569
Cdd:PRK05729 380 IKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWY-------------DEDGEVYVGREEPEAREKAL--------- 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 570 ivLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRD 649
Cdd:PRK05729 438 --LTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRD 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 650 AHGRKMSKSLGNVIDPMDVirgitleglhaqlvgsnldpreIEKakagqkqdYpqgipecGSDALRFALCAYITQARDIN 729
Cdd:PRK05729 516 EQGRKMSKSKGNVIDPLDL----------------------IDK--------Y-------GADALRFTLAALASPGRDIR 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 730 LDINRVLGYRFFCNKLWNATKFALLYFTGseKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAF 809
Cdd:PRK05729 559 FDEERVEGYRNFANKLWNASRFVLMNLEG--ADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEF 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 810 WLYDLCDVYLECLKPIFQsgsEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYPSNTSWRS 889
Cdd:PRK05729 637 IWNEFCDWYLELAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEESIMLAPWPEADEAID 713
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 890 TKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVF---DSPAPQGCAILt 966
Cdd:PRK05729 714 EAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEIladDEEAPEGAASA- 792
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 967 VTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIERIAAAIETL 1046
Cdd:PRK05729 793 VVGGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARL 872
|
.
gi 24653289 1047 K 1047
Cdd:PRK05729 873 K 873
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
90-1029 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1011.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasidaPNPNGK-FVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRT 168
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPD--------GNSNKPpFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYN 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 169 TLWVPGCDHAGIATQVVVEKLLWRDEKlSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRA 248
Cdd:TIGR00422 73 VLWLPGTDHAGIATQVKVEKKLGAEGK-TKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 249 VTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVE-GSDEEIIVAT 327
Cdd:TIGR00422 152 VKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGK----------------LYYIRYPLAnGSKDYLVVAT 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 328 TRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIF 407
Cdd:TIGR00422 216 TRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINIL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 408 NDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRS 487
Cdd:TIGR00422 296 DEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEE 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 488 GELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSftdpslQTGSnddeqyWIVARSEAEALTKAAerfgvDA 567
Cdd:TIGR00422 376 GEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCK------ECGE------VYVAKEEPLPDDKTN-----TG 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 568 SKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMV 647
Cdd:TIGR00422 439 PSVELEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLV 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 648 RDAHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALCAYITQARD 727
Cdd:TIGR00422 519 RDEQGRKMSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDD 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 728 INLDINRVLGYRFFCNKLWNATKFALLyftgSEKFDTELSA-SAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSAC 806
Cdd:TIGR00422 562 INFDWKRVESARNFLNKLWNASRFVLM----NLSDDLELSGgEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKAL 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 807 YAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPraNPAPSICVASYPS-NT 885
Cdd:TIGR00422 638 YEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK--EGADSIMLQSYPVvDA 715
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 886 SWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFDSPAP-QGCAI 964
Cdd:TIGR00422 716 EFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPeVTEAV 795
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653289 965 LTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKL 1029
Cdd:TIGR00422 796 VELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKL 860
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
90-1033 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 869.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 90 LPDAYSPRYVEAQWYSWWEKEGFFTPEygrasiDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTT 169
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGD------EHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 170 LWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAV 249
Cdd:PRK14900 89 LWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 250 TEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEipgrtflsipgyedkVEFGVLIKFAYKVEGSDEEIIVATTR 329
Cdd:PRK14900 169 REVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEE---------------AHQGELWSFAYPLADGSGEIVVATTR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 330 IETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFN 408
Cdd:PRK14900 234 PETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 409 DDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETlnNPMVVPI--CSRSKDVVEPLIKPQWYVSCSDMAASATEAVR 486
Cdd:PRK14900 314 PDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGA--KPHVLPLgrCQRSATILEPLLSDQWYVRIEPLARPAIEAVE 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 487 SGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPslqtgsnddeqywIVARSEAEALTKAAERfgvd 566
Cdd:PRK14900 392 QGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHV-------------TVARETPEACSTCGKA---- 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 567 askiVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPM 646
Cdd:PRK14900 455 ----ELRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPM 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 647 VRDAHGRKMSKSLGNVIDPMDVirgitleglhaqlvgsnldpreiekakagqkqdypqgIPECGSDALRFALCAYITQAR 726
Cdd:PRK14900 531 VRDEKGQKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGR 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 727 DINLDINRVLGYRFFCNKLWNATKFALLYFTGSEKfDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSAC 806
Cdd:PRK14900 574 DIKLAKERIEGYRAFANKLWNASRFALMNLSGYQE-RGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAV 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 807 YAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLP---RANPAP-SICVASYP 882
Cdd:PRK14900 653 YAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvGASAWAdSVLAAEYP 732
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 883 SNTswrSTKIESDVEFVQKAARI--IRSARSDYNLPNKVKTE----VYIVCTDSVPSEILKR----YASDLATISYCSNV 952
Cdd:PRK14900 733 RKG---EADEAAEAAFRPVLGIIdaVRNIRGEMGIPWKVKLGaqapVEIAVADPALRDLLQAgelaRVHRVAGVEGSRLV 809
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 953 VFDSPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCES 1032
Cdd:PRK14900 810 VAAATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARAEEL 889
|
.
gi 24653289 1033 R 1033
Cdd:PRK14900 890 R 890
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
100-1049 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 771.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 100 EAQWYSWWEKEGFFTPEYGRASidapNPngkFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAG 179
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGG----DP---FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 180 IATQVVVEKLLwRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEE 259
Cdd:PLN02943 139 IATQLVVEKML-ASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEK 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 260 GSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRtflsipgyedkvefgvLIKFAYKVEG-SDEEIIVATTRIETMLGDTA 338
Cdd:PLN02943 218 GLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGT----------------LYYIKYRVAGgSEDFLTIATTRPETLFGDVA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 339 VAVHPQDDRYKHLHGKFVVHPFST-RRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIigdy 417
Cdd:PLN02943 282 IAVNPEDDRYSKYIGKMAIVPMTYgRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTL---- 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 418 GEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHH 497
Cdd:PLN02943 358 NEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 498 TKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVsftdpslqTGSNDDEQYwIVARSEAEALTKAAERFGVDaskIVLKQDED 577
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWYI--------VGKDCEEDY-IVARSAEEALEKAREKYGKD---VEIYQDPD 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 578 VLDTWFSSGIFPFSVFGWPD-QTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMS 656
Cdd:PLN02943 506 VLDTWFSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMS 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 657 KSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALcAYITQARDINLDINRVL 736
Cdd:PLN02943 586 KTLGNVIDPLDTIK-------------------------------------EFGTDALRFTL-ALGTAGQDLNLSTERLT 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 737 GYRFFCNKLWNATKFALLYFTGSE-----------KFDTElSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSA 805
Cdd:PLN02943 628 SNKAFTNKLWNAGKFVLQNLPSQSdtsawehilacKFDKE-ESLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGRE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 806 CYAFWLYDLCDVYLECLKP-IFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPraNPAPSICVASYPSN 884
Cdd:PLN02943 707 IYDFFWSDFADWYIEASKTrLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALP--YRKEALIVSPWPQT 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 885 TSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILKRYASdLATISYC--SNVVFDSPAPqGC 962
Cdd:PLN02943 785 SLPKDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEV-LALLSRLdlQNVHFTDSPP-GD 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 963 AILTV----TGQCEVHLLLKGLVEADKEIAKLQKKSDQLVQTVGKLTQAIQAADYATKVPAEVQEANETKLCESRAEIER 1038
Cdd:PLN02943 863 ANQSVhlvaSEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIKL 942
|
970
....*....|.
gi 24653289 1039 IAAAIETLKLM 1049
Cdd:PLN02943 943 TKNRLAFLKST 953
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
102-731 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 664.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 102 QWYSWWEKEGFFTPEygrasIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIA 181
Cdd:pfam00133 1 QIYEFWDEQGYFKPE-----LEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 182 TQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGS 261
Cdd:pfam00133 76 TEQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 262 IYRSSRLVNWSCTLRSAISDIEVDkveipgrtflsipgYEDKVefGVLIKFAYKVEGSDE-EIIVATTRIETMLGDTAVA 340
Cdd:pfam00133 156 IYRGKKLVNWSPALNTALSNLEVE--------------YKDVK--GPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 341 VHP-------------------------------QDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHD 389
Cdd:pfam00133 220 VNPefdyvitgegyilaeallkslykkgtdkkilEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 390 PNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKDVVEPLIKPQ 469
Cdd:pfam00133 300 ENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQ 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 470 WYVSCSDMAASATEAVRsgELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTGSNDDeqyWIVA 549
Cdd:pfam00133 380 WFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFE---LVAG 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 550 RSEAEALTKAAERFGVD---ASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQ-TKDLQTFYPTSLLETGHDILFFWVARM 625
Cdd:pfam00133 455 RFEEEGSIKWLHREAKDklgYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRM 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 626 VFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqg 705
Cdd:pfam00133 535 IMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID----------------------------------- 579
|
650 660
....*....|....*....|....*.
gi 24653289 706 ipECGSDALRFALCaYITQARDINLD 731
Cdd:pfam00133 580 --KYGADALRLWLA-NSDYGRDINLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
129-730 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 617.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 129 GKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKlSRHDLGREKFIE 208
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGK-TRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 209 RIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVdkve 288
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 289 ipgrtflsipgyedkvefgvlikfaykvegsdeeiivattrietmlgdtavavhpqddrykhlhgkfvvhpfstrrlpiv 368
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 369 cdefvdmafgtgavkitpahdpndyevgkrcnlpfitifnddgyiigdygeftgmkrfecrkkileklkalnlyretlnn 448
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 449 pmvvpiCSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHV 528
Cdd:cd00817 156 ------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC 229
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 529 SftdpslqtgsndDEQYWIVARSEAEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPT 608
Cdd:cd00817 230 K------------DGGHWVVAREEDEAIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPT 297
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 609 SLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGItleglhaqlvgsnldp 688
Cdd:cd00817 298 SLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY---------------- 361
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 24653289 689 reiekakagqkqdypqgipecGSDALRFALCAYITQARDINL 730
Cdd:cd00817 362 ---------------------GADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
89-960 |
2.84e-166 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 508.96 E-value: 2.84e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 89 ALPDAYSPRYVEAQWYSWWEKEG--FFTPEYGRA--SIDAPnpngkfvmiipPPNVTGSLHLGHALTNAIEDAITRYHRM 164
Cdd:PRK13208 5 ELPKKYDPEELEEKWQKIWEEEGtyKFDPDERKPvySIDTP-----------PPTVSGSLHIGHVFSYTHTDFIARYQRM 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 165 KGRTTLWVPGCDHAGIATQVVVEKLLwrdeKLSRHDLGREKFIERIWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPK 244
Cdd:PRK13208 74 RGYNVFFPQGWDDNGLPTERKVEKYY----GIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 245 LCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVdkveipgrtflsipgyEDKVEFGVLIKFAYKVEGsDEEII 324
Cdd:PRK13208 150 YRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEV----------------EYREREGKLNYIKFPVED-GEEIE 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 325 VATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFI 404
Cdd:PRK13208 213 IATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTR 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 405 TIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLY--RETLNNPmvVPICSRSKDVVEPLIKPQWYVSCSDMAASAT 482
Cdd:PRK13208 293 IIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLgkQEPIKHN--VKFCERCDTPLEILVTRQWFIKVLDLKEELL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 483 EAVRsgELKIIPEHHTKTWYHWMDGIR-DWCVSRQ--------LWW----GHRIPAyhvsftdpslqtgsnDDEQYWIVA 549
Cdd:PRK13208 371 ERGK--EINWYPEHMRVRLENWIEGLNwDWCISRQryfgtpipVWYckdcGHPILP---------------DEEDLPVDP 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 550 RSEAEALTKAAERfGVDAskivLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDILFFW----VARM 625
Cdd:PRK13208 434 TKDEPPGYKCPQC-GSPG----FEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRA 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 626 VFfgqkLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIrgitleglhaqlvgsnldpreiekakagqkQDYpqg 705
Cdd:PRK13208 509 YL----LTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELL------------------------------EKY--- 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 706 ipecGSDALRFALcAYITQARDINLDINRV-LGYRFFcNKLWNATKFALLYftgseKFDTELSASAAINQMDAWILSRLA 784
Cdd:PRK13208 552 ----GADAVRYWA-ASARLGSDTPFDEKQVkIGRRLL-TKLWNASRFVLHF-----SADPEPDKAEVLEPLDRWILAKLA 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 785 AAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKP-IFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEEL 863
Cdd:PRK13208 621 KVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEV 700
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 864 YQRLPRAnpapSICVASYPS-NTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYIVCTDSVPsEILKRYASD 942
Cdd:PRK13208 701 WSWLYGG----SVHRASWPEpDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPADL-ELLEAAEED 775
|
890
....*....|....*...
gi 24653289 943 LATISYCSNVVFDSPAPQ 960
Cdd:PRK13208 776 LKAAGNIEELELVEGDPE 793
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
99-961 |
2.92e-92 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 315.48 E-value: 2.92e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 99 VEAQWYSWWEKEGFFtpeygRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCD-H 177
Cdd:COG0060 21 REPEILKFWEENDIY-----EKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 178 aGIATQVVVEKLLWRDeKLSRHDLGREKFIER--------IWDWRrekggriyEQLKSLGSSYDWTRVAFTMDPKLCRAV 249
Cdd:COG0060 96 -GLPIELKVEKELGIK-KKDIEKVGIAEFREKcreyalkyVDEQR--------EDFKRLGVWGDWDNPYLTMDPEYEESI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 250 TEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVdkveipgrtflsipGYEDKVEFGVLIKF----AYKVEGSDEEIIV 325
Cdd:COG0060 166 WWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV--------------EYKDVTSPSIYVKFpvkdEKALLLLEDAYLV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 326 A-TTRIETMLGDTAVAVHPQ----------DDRY---------------------------KHLHGKFVVHPFST----- 362
Cdd:COG0060 232 IwTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFYYvvgyd 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 363 RRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALN-- 440
Cdd:COG0060 312 RAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGal 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 441 LYRETLNNPmvVPICSRSKdvvEPLI---KPQWYVSCSDMAASATEAVRsgelKI--IPEHHTKTWYHWMDGIRDWCVSR 515
Cdd:COG0060 392 LAREKITHS--YPHCWRCK---TPLIyraTPQWFISMDKLRDRALEAIE----KVnwIPEWGEGRFGNMLENRPDWCISR 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 516 QLWWGHRIPAyhvsFTDPSLQTGSNDDEqywiVARSEAEALTKAAER--FGVDASKIVL-------------KQDEDVLD 580
Cdd:COG0060 463 QRYWGVPIPI----WVCEDCGELHRTEE----VIGSVAELLEEEGADawFELDLHRPFLdetlkcpkcggtmRRVPDVLD 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 581 TWFSSGIFPFSV------FGWPdqtKDL------QT---FYpTSLLEtghdilffwvARMVFfgqkllGKLPFKEVYLHP 645
Cdd:COG0060 535 VWFDSGSMHFAVlenreeLHFP---ADFylegsdQTrgwFY-SSLLT----------STALF------GRAPYKNVLTHG 594
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 646 MVRDAHGRKMSKSLGNVIDPMDVIrgitleglhaqlvgsnldpreiekakagqKQDypqgipecGSDALRFALcAYITQA 725
Cdd:COG0060 595 FVLDEDGRKMSKSLGNVVDPQEVI-----------------------------DKY--------GADILRLWV-ASSDYW 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 726 RDINLD---INRVlgYRFFcNKLWNATKFallyFTGS-EKFD--TELSASAAINQMDAWILSRLAAAIEACNTGFESYDF 799
Cdd:COG0060 637 GDLRFSdeiLKEV--RDVY-RRLRNTYRF----LLANlDDFDpaEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDF 709
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 800 AAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQ--TAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPaPSIC 877
Cdd:COG0060 710 HRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLdrRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAE-ESVH 788
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 878 VASYPS-NTSWRSTKIESDVEFVQK----AARIIRSARSDynlpNKVK---TEVYIVCTDSVPSEILKRYASDLATISYC 949
Cdd:COG0060 789 LADWPEvDEELIDEELEAKWDLVREvrsaVLKALEAARKE----KLIRqplEAAVVLYADEELAAALESLGDLLAEELNV 864
|
970
....*....|...
gi 24653289 950 SNVVF-DSPAPQG 961
Cdd:COG0060 865 SEVELvDDAEDLG 877
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
730-867 |
1.89e-60 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 202.40 E-value: 1.89e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 730 LDINRVLGYRFFCNKLWNATKFALLYFtgsEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAF 809
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNL---EDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 24653289 810 WLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRL 867
Cdd:cd07962 78 FWNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
100-942 |
1.14e-56 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 213.09 E-value: 1.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 100 EAQWYSWWEKEGFFTpeygraSIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAG 179
Cdd:PLN02843 9 EPEIQKLWEENQVYK------RVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 180 IATQVVVEKLLwrDEKlSRHDLG----REK---FIERIWDWRREkggriyeQLKSLGSSYDWTRVAFTMDPKLCRAVTEA 252
Cdd:PLN02843 83 LPIELKVLQSL--DQE-ARKELTpiklRAKaakFAKKTVDTQRE-------SFKRYGVWGDWENPYLTLDPEYEAAQIEV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 253 FVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEipGRTFLSI--------PGYEDKVEFGVLIKFAYkvegsdeeII 324
Cdd:PLN02843 153 FGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPE--GHVSKSIyvafpvvsPSETSPEELEEFLPGLS--------LA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 325 VATTRIETMLGDTAVAVHPQDD--------------------------RYKHLHGKFVV--------------------- 357
Cdd:PLN02843 223 IWTTTPWTMPANAAVAVNDKLQysvvevqsfsedestsggnkkkrpgnVLKEQQKLFLIvatdlvpaleakwgvklvvlk 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 358 -------------HPFSTRRLPIVCD-EFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGM 423
Cdd:PLN02843 303 tfpgsdlegcryiHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGL 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 424 KRF-ECRKKILEKLK-ALNLYRETLNNPMVvPICSRSKdvvEPLI---KPQWYVSCSDMAASATEAVRSgeLKIIPEHHT 498
Cdd:PLN02843 383 SVLgEGNAAVVEALDeAGSLLMEEAYGHKY-PYDWRTK---KPTIfraTEQWFASVEGFRQAALDAIDK--VKWIPAQGE 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 499 KTWYHWMDGIRDWCVSRQLWWGHRIPA-YHVSFTDPsLQTGSNDDEQYWIVARSEAEALTKAA------ERFGVDASKiv 571
Cdd:PLN02843 457 NRIRAMVSGRSDWCISRQRTWGVPIPVfYHVETKEP-LMNEETIAHVKSIVAQKGSDAWWYMDvedllpEKYRDKASD-- 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 572 LKQDEDVLDTWFSSGIFPFSVFGwpdQTKDLQtfYPTSLLETGHDILFFWvarmvfFGQKLL------GKLPFKEVYLHP 645
Cdd:PLN02843 534 YEKGTDTMDVWFDSGSSWAGVLG---SREGLS--YPADLYLEGSDQHRGW------FQSSLLtsvatkGKAPYKSVLTHG 602
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 646 MVRDAHGRKMSKSLGNVIDPMDVIRGitleglhaqlvGSNldpreiekakagQKQDypqgiPECGSDALRF--ALCAY-- 721
Cdd:PLN02843 603 FVLDEKGFKMSKSLGNVVDPRLVIEG-----------GKN------------QKQE-----PAYGADVLRLwvASVDYtg 654
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 722 --------ITQARDInldinrvlgYRffcnKLWNATKFALlyfTGSEKFDTELSAS-AAINQMDAWILSRLAAAIEACNT 792
Cdd:PLN02843 655 dvligpqiLKQMSDI---------YR----KLRGTLRYLL---GNLHDWKPDNAVPyEDLPSIDKYALFQLENVVNEIEE 718
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 793 GFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSeeQQTAARRT----LYVCLDYGLRLLSPFMPFITEELYQRLP 868
Cdd:PLN02843 719 SYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGG--TTSFTRRScqtvLAAHLLSLLRAIAPILPHLAEDAWQNLP 796
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 869 ---RANPAPSICVASYPS-NTSWRSTKIEsDVEFVQK-------AARIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILK 937
Cdd:PLN02843 797 fqeDGSAAESVFEAGWPTpNEEWLSFPAE-DVDFWSLllevrdeVNKVLESARNGKLIGASLEAKVYLHASDASLAARLA 875
|
....*
gi 24653289 938 RYASD 942
Cdd:PLN02843 876 ELCGA 880
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
130-670 |
2.72e-56 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 197.64 E-value: 2.72e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 130 KFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKlsrhDLGREKFIER 209
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKK----TIWIEEFRED 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 210 IWDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLvnwsctlrsaisdievdkvei 289
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP--------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 290 pgrtflsipgyedkvefgvlikfaykvegsdeeiivattrietmlgdtaVAVHPQddrykhlhgkfvvhpfstrrlpivc 369
Cdd:cd00668 136 -------------------------------------------------VRITEQ------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 370 dEFVDMafgtgavkitpahdpndyevgkrcnlpfitifnddgyiigdyGEFtgmkrfecRKKILEKLKalnlyretlnnp 449
Cdd:cd00668 142 -WFFDM------------------------------------------PKF--------KEKLLKALR------------ 158
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 450 mvvpicsrskdvveplikpqwyvscsdmaasateavrsgELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPayhvs 529
Cdd:cd00668 159 ---------------------------------------RGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP----- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 530 ftdpslqtgsnddeqywivarseaealtkaaerfgvdaskivlkqdEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTS 609
Cdd:cd00668 195 ----------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPAD 228
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653289 610 LLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIR 670
Cdd:cd00668 229 WHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVE 289
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
776-925 |
5.85e-40 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 144.47 E-value: 5.85e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 776 DAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQqtAARRTLYVCLDYGLRLLSPF 855
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS--RAQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 856 MPFITEELYQRLpranpapSICVASYPSNTSWRSTKIESDVEFVQKAARIIRSARSDYNLPNKVKTEVYI 925
Cdd:pfam08264 79 MPFITEELWQKE-------SIHLAPWPEDAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
121-869 |
7.63e-39 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 157.44 E-value: 7.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 121 SIDAPNPNGK-------FVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrD 193
Cdd:PTZ00427 87 SIDAFNTSNKlaknkkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEK----E 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 194 EKLSRhdlgREKFIERIWDWRREKGGRIY--------EQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRS 265
Cdd:PTZ00427 163 NNINK----KEDILKMGIDVYNEKCRGIVlkysnewvKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKS 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 266 SRLVNWSCTLRSAISDIEV--------DKVEIPGRTFLS--------IPGYEDKVEFGVLIKFAY--KVEGSDE------ 321
Cdd:PTZ00427 239 FKVMPYSCKCNTPISNFELnlnykdtpDPSIIISFVLCSdfpkveeeCNIEEDKQLLGEKYSVLYnnKRENSNNgnnnst 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 322 ---------EIIVATTRIETMLGDTAVAV------------------------------------------------HPQ 344
Cdd:PTZ00427 319 nnvcyaqhsEILAWTTTPWTLPSNLALCVnehftylrihhvksnrvvivgecrlewimkelkwnvedlkivnrfkgkELK 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 345 DDRYKHLHGKFV-VHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNL--PFITIFND----DGYIIGDY 417
Cdd:PTZ00427 399 GLRYKPLFTNFYeKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIFIDpldaNGYFTNEV 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 418 GEFTGMKRFECRKKILEKLKALNlyRETLNNPMV--VPICSRSKdvvEPLIK---PQWYVSCSDmaaSATEAVRSGELKI 492
Cdd:PTZ00427 479 EEVQNLYIKEADNVIKKKLKNEN--RLLSNNTIVhsYPFCWRSD---TPLIYraiPAWFIRVSN---STNELVKNNETTY 550
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 493 -IPEH-HTKTWYHWMDGIRDWCVSRQLWWGHRIPAYhvsfTDPSLQTgsnddeQYWIVARSEAEALT-----KAAERFGV 565
Cdd:PTZ00427 551 wIPAHiKEKKFHNWIKDAKDWCISRNRYWGTPIPIW----ADEKMET------VICVESIKHLEELSgvkniNDLHRHFI 620
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 566 DASKI---------VLKQDEDVLDTWFSSGIFPFSVFGWP--DQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLG 634
Cdd:PTZ00427 621 DHIEIknpkgktypKLKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFD 700
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 635 KLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSnldpreiEKAKAGQKQDYPQGIPECgsdAL 714
Cdd:PTZ00427 701 KAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINS-------VAVRAENLKFQEKGVNEV---VK 770
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 715 RFALCAYITqardinldinrvlgYRFFCNKL-----WNATKFAllyftgsekFDTELSASAAiNQMDAWILSRLAAAIEA 789
Cdd:PTZ00427 771 SFILPFYHS--------------FRFFSQEVtryecLNKKQFL---------FNTDYIYKND-NIMDQWIFSSVQSLTKS 826
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 790 CNTGFESYDFAAATSACYAFwLYDLCDVYLECLKPIFQ-SGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLP 868
Cdd:PTZ00427 827 VHTEMKAYKLYNVLPKLLQF-IENLTNWYIRLNRDRMRgSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLR 905
|
.
gi 24653289 869 R 869
Cdd:PTZ00427 906 R 906
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
94-867 |
2.88e-37 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 151.44 E-value: 2.88e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 94 YSPRYVEAQWYSWWEKEGFFTPEygrasiDAPNPNGKFVM-IIPPPnvTGSLHLGHALTNAIEDAITRYHRMKGRTTLWV 172
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVT------DDSSKPKYYILsMFPYP--SGALHMGHVRNYTITDVLSRYYRMKGYNVLHP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 173 PGCDHAGI-ATQVVVEKllwrdeklSRHDLgrekfieriwDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTE 251
Cdd:TIGR00396 73 IGWDAFGLpAENAAIKR--------GIHPA----------KWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQW 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 252 AFVRLHEEGSIYRSSRLVNWSCTL-------------RSAISDIEVDKVEIPgRTFLSIPGYEDKV-------------- 304
Cdd:TIGR00396 135 IFLELFEKGLAYVKEADVNWCPNDgtvlaneqvdsdgRSWRGDTPVEKKELK-QWFLKITAYAEELlndleeldhwpesv 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 305 ----------EFGVLIKFayKVEGSDEEIIVATTRIETMLGDTAVAV---HP-------------------------QDD 346
Cdd:TIGR00396 214 kemqrnwigkSEGVEITF--KIADHDEKITVFTTRPDTIFGVTYLALapeHPlvekaaennpkvaafikkilnktvaERT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 347 RYKHLH-----GKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITI-------------FN 408
Cdd:TIGR00396 292 KATKEKkgvdtGIKAIHPLTGEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVidpaekdlsltaaYT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 409 DDGYIIgDYGEFTGMKRFECRKKILEKLKALNLYRETLNnpmvvpicsrskdvveplikpqwyvscsdmaasateavrsg 488
Cdd:TIGR00396 372 EDGVLV-NSGEFNGLNSSEARNAIIDMLEKEGKGKRKVN----------------------------------------- 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 489 elkiipehhtktwYHwmdgIRDWCVSRQLWWGHRIPAYH------VSFTDPSLQTGSNDDEQYWIVARSEAEALTKAAE- 561
Cdd:TIGR00396 410 -------------YR----LRDWGFSRQRYWGEPIPIIHcedggvVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNv 472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 562 ---RFGVDAskivlKQDEDVLDTWFSSGIFpFSVFGWPDQT------KDLQTFYPTSLLETG--HDILFFWVARmvfFGQ 630
Cdd:TIGR00396 473 tcpSCGKPA-----LRETDTMDTFAGSSWY-YLRYLDPKNTdgpfdkEKAEYWLPVDLYIGGieHAILHLLYAR---FFH 543
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 631 KLLG-------KLPFKEVYLHPMV-----------------------RDAHGR--------KMSKSLGNVIDPMDVIRgi 672
Cdd:TIGR00396 544 KFLRdigyvntKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIVE-- 621
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 673 tleglhaqlvgsnldpreiekakagqkqdypqgipECGSDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNatkfa 752
Cdd:TIGR00396 622 -----------------------------------SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWN----- 661
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 753 lLYFTGSEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFE-SYDFAAATSACYAF----WLYDLCDVYLECLKPIfq 827
Cdd:TIGR00396 662 -LVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEkRESFNTAISAMMELlnklYKAKKEALMLEYLKGF-- 738
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 24653289 828 sgseeqqtaarrtlyvcldygLRLLSPFMPFITEELYQRL 867
Cdd:TIGR00396 739 ---------------------VTVLSPFAPHLAEELWEKL 757
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
137-918 |
4.14e-37 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 151.80 E-value: 4.14e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 137 PPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLL---WRDEKLsrhDLGREKFIER---- 209
Cdd:PLN02882 46 PPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLgikRRDDVL---KMGIDKYNEEcrsi 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 210 ----IWDWrrEKggriyeQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVd 285
Cdd:PLN02882 123 vtrySKEW--EK------TVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 286 kveipGRTFLSIPGYEDKVEFGVlikfaykVEGSDEEIIVA-TTRIETMLGDTAVAVHPQ-------------------- 344
Cdd:PLN02882 194 -----GLNYKDVSDPAVMVSFPI-------VGDPDNASFVAwTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaes 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 345 -------------------------------------DDRYKHLHGKFVvhPFSTRRLPIVCDEFVDMAFGTGAVKITPA 387
Cdd:PLN02882 262 rlsalptakpkskkgskpenaaegyevlakvpgsslvGKKYEPLFDYFS--EFSDTAFRVVADDYVTDDSGTGVVHCAPA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 388 HDPNDYEV-------GKRCNLPfiTIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLNNPMVVPICSRSKd 460
Cdd:PLN02882 340 FGEDDYRVclangiiEKGGNLP--VPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSD- 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 461 vvEPLIK---PQWYVSCSDMAASATEavRSGELKIIPEH-HTKTWYHWMDGIRDWCVSRQLWWGHRIPAYhvsftdpslq 536
Cdd:PLN02882 417 --TPLIYravPSWFVKVEEIKDRLLE--NNKQTYWVPDYvKEKRFHNWLENARDWAVSRSRFWGTPLPIW---------- 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 537 tgSNDDEQYWIVARS--EAEALT--KAAE--RFGVDASKI---------VLKQDEDVLDTWFSSGIFPFSVFGWPDQTKD 601
Cdd:PLN02882 483 --ISDDGEEVVVIGSiaELEKLSgvKVTDlhRHFIDHITIpssrgpefgVLRRVDDVFDCWFESGSMPYAYIHYPFENKE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 602 L-QTFYPTSLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVIRGITLEGLHAQ 680
Cdd:PLN02882 561 LfEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLY 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 681 LVGSnldpreiekakagqkqdypqgiPECGSDALRFALCAYITQARDINLDINRvlGYRFFcnkLWNATKFALlyfTGSE 760
Cdd:PLN02882 641 LINS----------------------PVVRAEPLRFKEEGVFGVVKDVFLPWYN--AYRFL---VQNAKRLEV---EGGA 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 761 KFDTELSAS--AAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFwLYDLCDVYLEC----LKPifQSGSEEQQ 834
Cdd:PLN02882 691 PFVPLDLAKlqNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTNIYVRFnrkrLKG--RTGEEDCR 767
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 835 TAArRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPA--PSICVASYPS-NTSWRSTKIESDVEFVQKAARIIRSARS 911
Cdd:PLN02882 768 TAL-STLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGseESIHYCSFPQvDEGELDERIEQSVSRMQTVIELARNIRE 846
|
....*..
gi 24653289 912 DYNLPNK 918
Cdd:PLN02882 847 RHNKPLK 853
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
91-882 |
6.80e-36 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 147.12 E-value: 6.80e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 91 PDAYSPRYVEAQWYSWWEKEGFFtpeygRASIDAPNPngKF---VMIiPPPnvTGSLHLGHALTNAIEDAITRYHRMKGR 167
Cdd:COG0495 2 QERYNPKEIEKKWQKYWEENGTF-----KADEDSSKP--KYyvlDMF-PYP--SGRLHMGHVRNYTIGDVVARYKRMQGY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 168 TTL----WvpgcD-------HAGIATQVvvekllwrdeklsrHdlgrekfiERIWDW------RRekggriyeQLKSLGS 230
Cdd:COG0495 72 NVLhpmgW----DafglpaeNAAIKNGV--------------H--------PAEWTYenianmRR--------QLKRLGL 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 231 SYDWTRVAFTMDP-------KLcravteaFVRLHEEGSIYRSSRLVNW--SC--TL--------RSAISDIEVDKVEIPG 291
Cdd:COG0495 118 SYDWSREIATCDPeyykwtqWI-------FLQLYEKGLAYRKEAPVNWcpVDqtVLaneqvidgRCWRCGAPVEKKELPQ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 292 rTFLSI--------------PGYEDKV----------EFGVLIKFayKVEGSDEEIIVATTRIETMLGDTAVAV---HP- 343
Cdd:COG0495 191 -WFLKItdyadellddldklDGWPEKVktmqrnwigrSEGAEVDF--PVEGSDEKITVFTTRPDTLFGATFMVLapeHPl 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 344 -----------------------------QDDRYKH--LHGKFVVHPFSTRRLPI-VCDeFVDMAFGTGAVKITPAHDPN 391
Cdd:COG0495 268 vkelatpeqnaavaafieeakkkseiertSETKEKTgvFTGLYAINPLTGEKIPIwIAD-YVLMDYGTGAVMAVPAHDQR 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 392 DYEVGKRCNLPFITI---------------FNDDGYIIgDYGEFTGMKRFECRKKILEKLKALNLYRETLNnpmvvpics 456
Cdd:COG0495 347 DFEFAKKYGLPIKQViapedgddpdileeaYTGDGVLI-NSGEFDGLDSEEAKEAIIEWLEEKGLGKRKVN--------- 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 457 rskdvveplikpqwyvscsdmaasateavrsgelkiipehhtktwYHwmdgIRDWCVSRQLWWGHRIPAYH--------- 527
Cdd:COG0495 417 ---------------------------------------------YR----LRDWLISRQRYWGEPIPIIHcedcgvvpv 447
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 528 ------------VSFTdpslQTGSNddeqywivarseaeALTKAAE-------RFGVDAskivlKQDEDVLDTWF-SSGI 587
Cdd:COG0495 448 pedqlpvelpedVDFD----PTGGS--------------PLARAPEwvnvtcpKCGGPA-----RRETDTMDTFVdSSWY 504
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 588 F-----------PFSvfgwPDQTK-----DLqtfYptslleTG---HDILFFWVARmvFFgQKLL---GKLPFKEvylhP 645
Cdd:COG0495 505 YlrytdphndeaPFD----PEAANywlpvDQ---Y------IGgieHAILHLLYAR--FF-TKVLrdlGLVSFDE----P 564
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 646 --------MVRD--------AHGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqDYpqgipec 709
Cdd:COG0495 565 fkrlltqgMVLEvgkdgvviGGIEKMSKSKGNVVDPDEIIE------------------------------KY------- 607
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 710 GSDALRFalcaYITQA----RDINLDINRVLG-YRFFcNKLWNatkfalLYFTGSEKFDTELSASAAinqMDAWILSRLA 784
Cdd:COG0495 608 GADTLRL----FEMFAgppeRDLEWSDSGVEGaYRFL-NRVWR------LVVDEAEALKLDVADLSE---ADKELRRALH 673
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 785 AAIEACNTGFESYDFAAATSACYAF--WLYDLCDvyleclkpifqsgSEEQQTAARRTLYVCLdygLRLLSPFMPFITEE 862
Cdd:COG0495 674 KTIKKVTEDIERLRFNTAIAALMELvnALYKAKD-------------SGEADRAVLREALETL---VLLLAPFAPHIAEE 737
|
970 980
....*....|....*....|
gi 24653289 863 LYQRLpraNPAPSICVASYP 882
Cdd:COG0495 738 LWERL---GHEGSVADAPWP 754
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
144-937 |
4.68e-31 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 131.91 E-value: 4.68e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 144 LHLGHALTNAIEDAITRYHRMKGRTTLWvPGCDHA------GIAtqvvvEKLLWRDEKL-----SRHDLGRE---KFI-- 207
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PMAFHVtgtpilGIA-----ERIARGDPETielykSLYGIPEEeleKFKdp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 208 ERIWDWRREKggrIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISD---IEV 284
Cdd:PRK12300 75 EYIVEYFSEE---AKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdlLDG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 285 DKVEIpgrtflsipgyedkVEFgVLIKFAykvEGSDEEIIVATTRIETMLGDTAVAVHP--------------------- 343
Cdd:PRK12300 152 EEPEI--------------VEY-TLIKFE---ESEDLILPAATLRPETIFGVTNLWVNPdatyvkaevdgekwivskeaa 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 344 -----QDDRYK--------HLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDY----EVGKRCNL----- 401
Cdd:PRK12300 214 eklsfQDRDVEiieeikgsELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldvie 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 402 --PFITI-----F--------------NDD----------------GYIIGDYGEFTGMKRFECRKKILEKLKALNLYRE 444
Cdd:PRK12300 294 piPLIEVegygeFpakevveklgiksqEDPeleeatkevyraefhkGVLKENTGEYAGKPVREAREKITKDLIEKGIADI 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 445 --TLNNPMVVPICSrSKDVVEpLIKPQWYVSCSDMA--ASATEAVrsGELKIIPEHhTKTWYH----WMDgirDWCVSRQ 516
Cdd:PRK12300 374 myEFSNRPVYCRCG-TECVVK-VVKDQWFIDYSDPEwkELAHKAL--DNMEIIPEE-YRKEFEntidWLK---DRACARR 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 517 LWWGHRIPAyhvsftdpslqtgsnDDEqyWIVarseaEALT------------KAAERFGVDASKIvlkqDEDVLDTWF- 583
Cdd:PRK12300 446 RGLGTRLPW---------------DEE--WII-----ESLSdstiymayytiaHKIREYGIKPEQL----TPEFFDYVFl 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 584 ----------SSGIFPfsvfgwpDQTKDLQT----FYPTSLLETGHD-----ILFF------------WVARMVFFGQKL 632
Cdd:PRK12300 500 gkgdpeevskKTGIPK-------EILEEMREeflyWYPVDWRHSGKDlipnhLTFFifnhvaifpeekWPRGIVVNGFVL 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 633 LGklpfkevylhpmvrdahGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldpreiekakagqkqdypqgipECGSD 712
Cdd:PRK12300 573 LE-----------------GKKMSKSKGNVIPLRKAIE-------------------------------------EYGAD 598
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 713 ALRFAL--CAYITQarDINLDINRVLGYRFFCNKLWNatkFAL-LYFTGSEKFDTELsasaainqmDAWILSRLAAAIEA 789
Cdd:PRK12300 599 VVRLYLtsSAELLQ--DADWREKEVESVRRQLERFYE---LAKeLIEIGGEEELRFI---------DKWLLSRLNRIIKE 664
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 790 CNTGFESYDF-AAATSACYAfwLYDLCDVYLEclkpifqSGSEEQQTAARRTLyvclDYGLRLLSPFMPFITEELYQRLP 868
Cdd:PRK12300 665 TTEAMESFQTrDAVQEAFYE--LLNDLRWYLR-------RVGEANNKVLREVL----EIWIRLLAPFTPHLAEELWHKLG 731
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 869 RANPapsICVASYPS-NTSWRSTKIESDVEFVQkaaRIIRSARSDYNLPNKVKTEVYIVCTDSVPSEILK 937
Cdd:PRK12300 732 GEGF---VSLEKWPEpDESKIDEEAELAEEYVK---RLIEDIREILKVAKIKPKKVYIYVAPDWKYEVLE 795
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
137-669 |
2.05e-30 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 123.50 E-value: 2.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 137 PPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIER------- 209
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAKcrefalr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 210 -IWDWRrekggriyEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWsctlrsaisdievdkve 288
Cdd:cd00818 89 yVDEQE--------EQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 289 ipgrtflsipgyedkvefgvlikfaykvegsdeeiivattrietmlgdtavavhpqddrykhlhgkfvvhpfstrrlPIv 368
Cdd:cd00818 144 -----------------------------------------------------------------------------PL- 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 369 cdefvdmafgtgavkitpahdpndyevgkrcnlpfitifnddgyiigdygeftgmkrfecrkkileklkalnLYRETlnn 448
Cdd:cd00818 146 ------------------------------------------------------------------------IYRAT--- 150
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 449 pmvvpicsrskdvveplikPQWYVSCSDMAASATEAVRsgELKIIPEHHTKTWYHWMDGIRDWCVSRQLWWGHRIPayhv 528
Cdd:cd00818 151 -------------------PQWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIP---- 205
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 529 sftdpslqtgsnddeqywiVARSEaealtkaaerfgvDASKIVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPT 608
Cdd:cd00818 206 -------------------VWYCE-------------DCGEVLVRRVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPA 253
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653289 609 SLLETGHDILFFWVARMVFFGQKLLGKLPFKEVYLHPMVRDAHGRKMSKSLGNVIDPMDVI 669
Cdd:cd00818 254 DFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
65-440 |
3.76e-27 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 119.54 E-value: 3.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 65 TKEVKEAAVYTAQTAPGEKKDLSGALPDAYSPRYVEAQWYSWWEK-EGFFTPEygraSIDAPNPNgKFVM-IIPPPNVTG 142
Cdd:PLN02563 51 SRSLTRRAFAAPSALTSTTAKTTPAAKRAYPFHEIEPKWQRYWEEnRTFRTPD----DVDTSKPK-FYVLdMFPYPSGAG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 143 sLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGI-ATQVVVEKllwrdeklSRHDlgREKFIERIwdwrrekgGRI 221
Cdd:PLN02563 126 -LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLpAEQYAIET--------GTHP--KITTLKNI--------ARF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 222 YEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDK----------VEIPG 291
Cdd:PLN02563 187 RSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglsergghpvIRKPM 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 292 RTF-LSIPGYEDK-----------------------------VEFGVLikfAYKVEGSDEEIIVATTRIETMLGDTAVAV 341
Cdd:PLN02563 267 RQWmLKITAYADRlledlddldwpesikemqrnwigrsegaeLDFSVL---DGEGKERDEKITVYTTRPDTLFGATYLVV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 342 HPQ---------DDRYKHLH--------------------------GKFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITP 386
Cdd:PLN02563 344 APEhpllsslttAEQKEAVEeyvdaasrksdlertelqkektgvftGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVP 423
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653289 387 AHDPNDYEVGKRCNLPFITI--------------FNDDGYIIG---DYGEFTGMKRFECRKKILEKLKALN 440
Cdd:PLN02563 424 AHDTRDFEFAQKFDLPIKWVvkpadgneddaekaYTGEGVIVNsssSGLDINGLSSKEAAKKVIEWLEETG 494
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
739-910 |
4.56e-23 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 97.62 E-value: 4.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 739 RFFCNKLWNATKFALLY-----FTGSEKFDTELSAsaaiNQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLyD 813
Cdd:cd07961 11 RKVLLPLWNAYRFFVTYanldgFDPGKDDDAVASL----NVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFID-E 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 814 LCDVYLECLKPIF-QSGSEEQQTAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAP--SICVASYPS-NTSWRS 889
Cdd:cd07961 86 LTNWYIRRNRKRFwGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDApeSVHLLDWPEvDESLID 165
|
170 180
....*....|....*....|.
gi 24653289 890 TKIESDVEFVQKaarIIRSAR 910
Cdd:cd07961 166 EELEEAMELVRE---IVELGR 183
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
307-436 |
4.23e-17 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 80.28 E-value: 4.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 307 GVLIKFayKVEGSDEEIIVATTRIETMLGDTAVAV---HP---------------------QDDRYKHLH---------G 353
Cdd:pfam13603 9 GAEITF--PVEGTDEKIEVFTTRPDTLMGVTFVALapeHPlveklaeknpevaafieecknTSEIERTSEtkekegvftG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 354 KFVVHPFSTRRLPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFI-TIFNDDGYIIGDY--------------G 418
Cdd:pfam13603 87 LYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKpVIQPEDGDLDLDImteayteegilvnsG 166
|
170
....*....|....*...
gi 24653289 419 EFTGMKRFECRKKILEKL 436
Cdd:pfam13603 167 EFDGLDSEEAKEAIIKKL 184
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
506-867 |
6.61e-17 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 85.17 E-value: 6.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 506 DGIRDWCVSRQLWWGHRIPayhvsftdpslqtgsNDDEQY---WIvarseaEALT-------KAAERFGVDASkivlkqd 575
Cdd:COG0143 221 EGLQDLSISRDFDWGIPVP---------------GDPGKVfyvWF------DALIgyisatkGYADDRGLPED------- 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 576 edvLDTWfssgifpfsvfgWPDQTKDLQTFYptslletGHDILFF----WVArMvffgqkLLG---KLPfKEVYlhpmvr 648
Cdd:COG0143 273 ---FEKY------------WPAPDTELVHFI-------GKDIIRFhaiiWPA-M------LMAaglPLP-KKVF------ 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 649 dAH------GRKMSKSLGNVIDPMDVIrgitleglhaqlvgsnldpreiekakagqkQDYpqgipecGSDALRFALCAYI 722
Cdd:COG0143 317 -AHgfltveGEKMSKSRGNVIDPDDLL------------------------------DRY-------GPDALRYYLLREV 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 723 TQARDINLD-------------------INRVLGyrfFCNKlwnatkfallyftgseKFDTELSASAAINQMDAWILSRL 783
Cdd:COG0143 359 PFGQDGDFSwedfvarvnsdlandlgnlASRTLS---MIHK----------------YFDGKVPEPGELTEADEELLAEA 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 784 AAAIEACNTGFESYDFAAATSACYAFWlyDLCDVYLECLKPIFQSgSEEQQTAARRTLYVCLdYGLR----LLSPFMPFI 859
Cdd:COG0143 420 EAALEEVAEAMEAFEFRKALEEIMALA--RAANKYIDETAPWKLA-KDEDPERLATVLYTLL-EALRilaiLLKPFLPET 495
|
....*...
gi 24653289 860 TEELYQRL 867
Cdd:COG0143 496 AEKILEQL 503
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
130-271 |
3.01e-14 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 74.98 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 130 KFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAG-----IAtqvvvekllwrdEKLSRHDLgre 204
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGlpaenAA------------IKIGRDPE--- 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24653289 205 kfieriwDWRREKGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNW 271
Cdd:cd00812 66 -------DWTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
738-914 |
1.27e-13 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 70.25 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 738 YRffcnKLWNATKFAL--LY-FtgseKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDL 814
Cdd:cd07960 13 YR----KIRNTFRFLLgnLNdF----DPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 815 CDVYLE-------CLKPifqsGSEEQQtAARRTLYVCLDYGLRLLSPFMPFITEELYQRLPRANPAPSICVASYPS-NTS 886
Cdd:cd07960 85 SAFYLDiikdrlyCDAK----DSLERR-SAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFLEDWPElPEE 159
|
170 180
....*....|....*....|....*...
gi 24653289 887 WRSTKIESDVEfvqkaarIIRSARSDYN 914
Cdd:cd07960 160 WKDEELEEKWE-------KLLALRDEVN 180
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
138-266 |
2.79e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 63.46 E-value: 2.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 138 PNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrdeklsrHDLGREKFIERIWDwrrek 217
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK----------EGITPEELVDRYHE----- 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 24653289 218 ggRIYEQLKSLGSSYD-WTRvafTMDPKLCRAVTEAFVRLHEEGSIYRSS 266
Cdd:pfam09334 73 --IHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKE 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
130-266 |
2.52e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 61.05 E-value: 2.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 130 KFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGiatqvvvEKLLWRDEKlsrhdLGREKFier 209
Cdd:PRK11893 2 KFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHG-------QKIQRKAEE-----AGISPQ--- 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 24653289 210 iwDWRREKGGRIYEQLKSLGSSYD-WTRvafTMDPKLCRAVTEAFVRLHEEGSIYRSS 266
Cdd:PRK11893 67 --ELADRNSAAFKRLWEALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGK 119
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
614-867 |
4.61e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 60.28 E-value: 4.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 614 GHDILFF----WVArmvfFGQKLLGKLPfKEVYLHP-MVRDahGRKMSKSLGNVIDPMDVIRgitleglhaqlvgsnldp 688
Cdd:PRK11893 261 GKDILRFhavyWPA----FLMAAGLPLP-KRVFAHGfLTLD--GEKMSKSLGNVIDPFDLVD------------------ 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 689 reiekakagqkqdypqgipECGSDALR--FALCAYITQARDINLD-----INRVLGYRFfcNKLWNAT-KFALLYFTGSE 760
Cdd:PRK11893 316 -------------------EYGVDAVRyfLLREIPFGQDGDFSREafinrINADLANDL--GNLAQRTlSMIAKNFDGKV 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 761 KFDTELSASaainqmDAWILSRLAAAIEACNTGFESYDFAAatsACYAFW-LYDLCDVYLECLKP--IFQSGSEEQQTaa 837
Cdd:PRK11893 375 PEPGALTEA------DEALLEAAAALLERVRAAMDNLAFDK---ALEAILaLVRAANKYIDEQAPwsLAKTDPERLAT-- 443
|
250 260 270
....*....|....*....|....*....|....
gi 24653289 838 rrTLYVCLDYgLR----LLSPFMPFITEELYQRL 867
Cdd:PRK11893 444 --VLYTLLEV-LRgiavLLQPVMPELAAKILDQL 474
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
138-263 |
5.61e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.08 E-value: 5.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 138 PNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrdEKLSRHDLGRE--KFIERIWDWrr 215
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEE-----EGVTPQELCDKyhEIFKDLFKW-- 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 24653289 216 ekggriyeqlksLGSSYD-WTRvafTMDPKLCRAVTEAFVRLHEEGSIY 263
Cdd:cd00814 82 ------------LNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIY 115
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
733-856 |
1.16e-08 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 54.05 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 733 NRVLGYRFFCNKLWNATKFALLYFTG-SEKFDTELsasaaINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAFWL 811
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGtQPKWDNEL-----LEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTN 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 24653289 812 YDlcDVYLECLKPIFQSgsEEQQTAARRTLYVCLDYGLRLLSPFM 856
Cdd:cd07375 77 EL--NWYLDELKPALQT--EELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
725-867 |
1.17e-06 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 48.64 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 725 ARDI-NLdINRVLGyrfFCNKlwnatkfallyftgseKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAAT 803
Cdd:cd07957 6 ANNLgNL-VNRTLN---MASK----------------YFGGVVPEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKAL 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24653289 804 SAcyAFWLYDLCDVYLECLKPiFQSGSEEQQTAARRTLYVCLdYGLR----LLSPFMPFITEELYQRL 867
Cdd:cd07957 66 EE--IMELARAANKYIDETAP-WKLAKEEDPERLATVLYVLL-ELLRilaiLLSPFMPETAEKILDQL 129
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
594-867 |
1.94e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 51.72 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 594 GWPDQTKDL-QTFYPTSLLETGHDIL-F---FWVArMVffgqKLLG-KLPfKEVYlhpmvrdAHG------RKMSKSLGN 661
Cdd:PRK12267 240 GYGSDDDELfKKFWPADVHLVGKDILrFhaiYWPI-ML----MALGlPLP-KKVF-------AHGwwlmkdGKMSKSKGN 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 662 VIDPMDVIrgitleglhaqlvgsnldpreiekakagqkQDYpqgipecGSDALRFALCAYITQARD-----------INL 730
Cdd:PRK12267 307 VVDPEELV------------------------------DRY-------GLDALRYYLLREVPFGSDgdfspealverINS 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 731 DINrvlgyrffcNKLWNatkfaLLYFTGS--EK-FDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSacy 807
Cdd:PRK12267 350 DLA---------NDLGN-----LLNRTVAmiNKyFDGEIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALE--- 412
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24653289 808 AFW-LYDLCDVYLECLKPIFQSGSEEQQTAARRTLYVCLDyGLR----LLSPFMPFITEELYQRL 867
Cdd:PRK12267 413 EVWkLISRANKYIDETAPWVLAKDEGKKERLATVMYHLAE-SLRkvavLLSPFMPETSKKIFEQL 476
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
140-263 |
1.05e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 49.41 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 140 VTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGiatqvvvEKllwrdeklsrhdlgrekfIERIwdwRREKG- 218
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG-------QK------------------IQQA---AEKAGk 66
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 24653289 219 ----------GRIYEQLKSLGSSYDwtrvAF--TMDPKLCRAVTEAFVRLHEEGSIY 263
Cdd:PRK12267 67 tpqeyvdeisAGFKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIY 119
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
466-669 |
1.36e-05 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 48.40 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 466 IKPQWYV--SCSDMAASATEAVRsgELKIIPEHHTKTWYHWMDgirdwcVSRQLWWGHRIPayhvsftdpslqtgsndde 543
Cdd:cd00812 128 LLDQWFLkySETEWKEKLLKDLE--KLDGWPEEVRAMQENWIG------CSRQRYWGTPIP------------------- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 544 qyWivarseaealtkaaerfgvdaskivlkqdEDVLDTWFSSGIFP--FSVFGWPDQ---------TKDLQTFYPTSLLE 612
Cdd:cd00812 181 --W-----------------------------TDTMESLSDSTWYYarYTDAHNLEQpyegdlefdREEFEYWYPVDIYI 229
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653289 613 TGHD-----ILF--FWVArmVFFGQKLLGKLPFKEVYLHPMVRdAHGRKMSKSLGNVIDPMDVI 669
Cdd:cd00812 230 GGKEhapnhLLYsrFNHK--ALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
99-170 |
4.19e-05 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 47.76 E-value: 4.19e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24653289 99 VEAQWYSWWEKEGFFTPEYGRasiDAPNPNGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTL 170
Cdd:PLN02959 18 IEVAVQKWWEEEKVFEAEAGD---EPPKPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
972-1047 |
7.45e-05 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 41.87 E-value: 7.45e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653289 972 EVHLLLKGLVEADKEIAKLQKKsdqlvqtvgkltqaIQAADYATKVPAEVQEANETKLCESRAEIERIAAAIETLK 1047
Cdd:pfam10458 5 ERARLEKELAKLQKEIERVQGK--------------LANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
776-867 |
7.84e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 42.96 E-value: 7.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 776 DAWILSRLAAAIEACNTGFESYDFAAATSACYaFWLYDLCDVYLEclkpifqSGSEEqqtAARRTLYVCLDYGLRLLSPF 855
Cdd:cd07959 37 DRWLLSRLNRLIKETTEAYENMQFREALKEGL-YELQNDLDWYRE-------RGGAG---MNKDLLRRFIEVWTRLLAPF 105
|
90
....*....|..
gi 24653289 856 MPFITEELYQRL 867
Cdd:cd07959 106 APHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
738-867 |
6.15e-04 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 40.67 E-value: 6.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 738 YRFFcNKLWNatkfallYFTGSEKFDTELSASAAINQMDAWILSRLAAAIEACNTGFESYDFAAATSACYAF--WLYDLc 815
Cdd:cd07958 10 YRFL-NRVWR-------LVTELAEALAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELvnALYKY- 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24653289 816 DVYLECLKPIFQSGSEeqqtaarrTLyvcldygLRLLSPFMPFITEELYQRL 867
Cdd:cd07958 81 KKKDAQHAAVLREALE--------TL-------VLLLAPFAPHIAEELWEEL 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
523-670 |
1.12e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 42.78 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 523 IPAYHVSFTDPSLQTgsnDDEQYWIVARSEAEALTKAAERFGVDaskiVLKQDEDVLDTWFSSGIFPFSVFGWPDQTKDL 602
Cdd:PLN02224 240 ILAQNPRFVQPSYRL---NEVQSWIKSGLRDFSISRALVDWGIP----VPDDDKQTIYVWFDALLGYISALTEDNKQQNL 312
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24653289 603 QTF----YPTSLLETGHDILFF----WVARMVFFGQKLlGKLPFKEVYLhpmVRDahGRKMSKSLGNVIDPMDVIR 670
Cdd:PLN02224 313 ETAvsfgWPASLHLIGKDILRFhavyWPAMLMSAGLEL-PKMVFGHGFL---TKD--GMKMGKSLGNTLEPFELVQ 382
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
133-214 |
1.31e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 40.16 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 133 MIIPPPNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGiatqvvvEKLLWRD-EKLSRHDLGREKFIERI- 210
Cdd:cd00802 1 TTFSGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAG-------GLIGDPAnKKGENAKAFVERWIERIk 73
|
....*.
gi 24653289 211 --WDWR 214
Cdd:cd00802 74 edVEYM 79
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
138-264 |
2.15e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 42.06 E-value: 2.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653289 138 PNVTGSLHLGHALTNAIEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKllwrdEKLSrhdlgREKFIERIWdwrrek 217
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEK-----EGIT-----PEELIARYH------ 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 24653289 218 gGRIYEQLKSLGSSYD-WTRvafTMDPkLCRAVTEAFVR-LHEEGSIYR 264
Cdd:PRK00133 75 -AEHKRDFAGFGISFDnYGS---THSE-ENRELAQEIYLkLKENGYIYE 118
|
|
| |
