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    Mettl23 methyltransferase 23, arginine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl23provided by RGD
    Official Full Name
    methyltransferase 23, arginineprovided by RGD
    Primary source
    RGD:1306284
    See related
    AllianceGenome:RGD:1306284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306284
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; heat shock protein binding activity; and histone H3R17 methyltransferase activity. Predicted to be involved in cognition; epigenetic programming in the zygotic pronuclei; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of with a positive effect on epigenetic programing of male pronucleus. Predicted to be located in female pronucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and male pronucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 439.7), Spleen (RPKM 301.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl23 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102546102..102550782)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102047090..102053379)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105787935..105793307)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene matrix remodeling associated 7 Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene serine and arginine rich splicing factor 2 Neighboring gene major facilitator superfamily domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. METTL23, a transcriptional partner of GABPA, is essential for human cognition. Reiff RE, et al. Hum Mol Genet, 2014 Jul 1. PMID 24501276, Free PMC Article
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105570

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3R17 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3R17 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3R17 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-arginine omega-N asymmetric methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect epigenetic programing of male pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect epigenetic programing of male pronucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epigenetic programming in the zygotic pronuclei ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic programming in the zygotic pronuclei ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in female pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in female pronucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in male pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in male pronucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-arginine methyltransferase METTL23
    Names
    methyltransferase like 23
    methyltransferase-like protein 23
    probable methyltransferase-like protein 23
    NP_001008284.1
    XP_006247860.1
    XP_038941626.1
    XP_063124861.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008283.1 → NP_001008284.1  histone-arginine methyltransferase METTL23

      See identical proteins and their annotated locations for NP_001008284.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086594
      UniProtKB/Swiss-Prot
      Q5RJL2
      UniProtKB/TrEMBL
      A6HKZ5
      Conserved Domains (1) summary
      cl17173
      Location:35 → 161
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102546102..102550782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247798.4 → XP_006247860.1  histone-arginine methyltransferase METTL23 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:8 → 134
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_039085698.2 → XP_038941626.1  histone-arginine methyltransferase METTL23 isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:35 → 141
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_063268791.1 → XP_063124861.1  histone-arginine methyltransferase METTL23 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJL2.1 GenPept UniProtKB/Swiss-Prot:Q5RJL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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