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Conserved domains on  [gi|56605664|ref|NP_001008284|]
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histone-arginine methyltransferase METTL23 [Rattus norvegicus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 35-161 3.03e-18

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 78.53  E-value: 3.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605664    35 GMYVWPCAVVLAQYL------WFHRRVLPGKAVLEIGAGVSLPGILAAK--CGAKVTLSDSPELPHCLDicwQSCQMNNL 106
Cdd:pfam10294  18 GGHVWDAAVVLSKYLemkifkELGANNLSGLNVLELGSGTGLVGIAVALllPGASVTITDLEEALELLK---KNIELNAL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605664   107 -PQVQIVGLTWGH-ISKDTLSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKV 161
Cdd:pfam10294  95 sSKVVVKVLDWGEnLPPDLFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKESVI 151
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 35-161 3.03e-18

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 78.53  E-value: 3.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605664    35 GMYVWPCAVVLAQYL------WFHRRVLPGKAVLEIGAGVSLPGILAAK--CGAKVTLSDSPELPHCLDicwQSCQMNNL 106
Cdd:pfam10294  18 GGHVWDAAVVLSKYLemkifkELGANNLSGLNVLELGSGTGLVGIAVALllPGASVTITDLEEALELLK---KNIELNAL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605664   107 -PQVQIVGLTWGH-ISKDTLSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKV 161
Cdd:pfam10294  95 sSKVVVKVLDWGEnLPPDLFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKESVI 151
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 34-149 2.34e-17

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 77.23  E-value: 2.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605664  34 YGMYVWPCAVVLAQYLWFHRRVlPGKAVLEIGAGVSLPGILAAKCGA-KVTLSDSpeLPHCLDICWQSCQMNNLPqVQIV 112
Cdd:COG3897  48 FWAFLWPSGQALARYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAaDVTATDY--DPEALAALRLNAALNGVA-ITTR 123

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56605664 113 GLTWGhiskDTLSLPPQDIILGSDVFFEPEDFESILA 149
Cdd:COG3897 124 LGDWR----DPPAAGGFDLILGGDVLYERDLAEPLLP 156
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 35-161 3.03e-18

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 78.53  E-value: 3.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605664    35 GMYVWPCAVVLAQYL------WFHRRVLPGKAVLEIGAGVSLPGILAAK--CGAKVTLSDSPELPHCLDicwQSCQMNNL 106
Cdd:pfam10294  18 GGHVWDAAVVLSKYLemkifkELGANNLSGLNVLELGSGTGLVGIAVALllPGASVTITDLEEALELLK---KNIELNAL 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 56605664   107 -PQVQIVGLTWGH-ISKDTLSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKV 161
Cdd:pfam10294  95 sSKVVVKVLDWGEnLPPDLFDGHPVDLILAADCVYNEDSFPLLEKTLKDLLGKESVI 151
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 34-149 2.34e-17

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 77.23  E-value: 2.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605664  34 YGMYVWPCAVVLAQYLWFHRRVlPGKAVLEIGAGVSLPGILAAKCGA-KVTLSDSpeLPHCLDICWQSCQMNNLPqVQIV 112
Cdd:COG3897  48 FWAFLWPSGQALARYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAaDVTATDY--DPEALAALRLNAALNGVA-ITTR 123

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 56605664 113 GLTWGhiskDTLSLPPQDIILGSDVFFEPEDFESILA 149
Cdd:COG3897 124 LGDWR----DPPAAGGFDLILGGDVLYERDLAEPLLP 156
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 50-152 8.94e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 34.99  E-value: 8.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605664  50 WFHRRVLPGKAVLEIGAGvslPGILA---AKCGAKVTLSD-SPELphcLDICWQscqmnnlpQVQIVGLTWGHISKDTLS 125
Cdd:COG2227  17 LLARLLPAGGRVLDVGCG---TGRLAlalARRGADVTGVDiSPEA---LEIARE--------RAAELNVDFVQGDLEDLP 82

                        90       100
                ....*....|....*....|....*....
gi 56605664 126 LPPQ--DIILGSDVFFEPEDFESILATVY 152
Cdd:COG2227  83 LEDGsfDLVICSEVLEHLPDPAALLRELA 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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