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Conserved domains on  [gi|1958657711|ref|XP_038941626|]
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histone-arginine methyltransferase METTL23 isoform X2 [Rattus norvegicus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1904217)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnt1 super family cl43977
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 34-142 1.48e-16

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3897:

Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 72.99  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657711  34 YGMYVWPCAVVLAQYLWFHRRVlPGKAVLEIGAGVSLPGILAAKCGA-KVTLSDSpeLPHCLDICWQSCQMNNLPqVQIV 112
Cdd:COG3897    48 FWAFLWPSGQALARYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAaDVTATDY--DPEALAALRLNAALNGVA-ITTR 123

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958657711 113 GLTWGhiskDTLSLPPQDIILGSDVFFEPE 142
Cdd:COG3897   124 LGDWR----DPPAAGGFDLILGGDVLYERD 149
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 34-142 1.48e-16

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 72.99  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657711  34 YGMYVWPCAVVLAQYLWFHRRVlPGKAVLEIGAGVSLPGILAAKCGA-KVTLSDSpeLPHCLDICWQSCQMNNLPqVQIV 112
Cdd:COG3897    48 FWAFLWPSGQALARYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAaDVTATDY--DPEALAALRLNAALNGVA-ITTR 123

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958657711 113 GLTWGhiskDTLSLPPQDIILGSDVFFEPE 142
Cdd:COG3897   124 LGDWR----DPPAAGGFDLILGGDVLYERD 149
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 35-141 2.59e-15

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 68.90  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657711  35 GMYVWPCAVVLAQYL------WFHRRVLPGKAVLEIGAGVSLPGI-LAAKC-GAKVTLSDSPELPHCLDicwQSCQMNNL 106
Cdd:pfam10294  18 GGHVWDAAVVLSKYLemkifkELGANNLSGLNVLELGSGTGLVGIaVALLLpGASVTITDLEEALELLK---KNIELNAL 94

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958657711 107 -PQVQIVGLTWGH-ISKDTLSLPPQDIILGSD-VFFEP 141
Cdd:pfam10294  95 sSKVVVKVLDWGEnLPPDLFDGHPVDLILAADcVYNED 132
PRK14968 PRK14968
putative methyltransferase; Provisional
 45-106 9.81e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 34.87  E-value: 9.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958657711  45 LAQYLwfhrRVLPGKAVLEIGAGVSLPGILAAKCGAKVTLSDSPelPHCLDICWQSCQMNNL 106
Cdd:PRK14968   15 LAENA----VDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDIN--PYAVECAKCNAKLNNI 70
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 34-142 1.48e-16

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 72.99  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657711  34 YGMYVWPCAVVLAQYLWFHRRVlPGKAVLEIGAGVSLPGILAAKCGA-KVTLSDSpeLPHCLDICWQSCQMNNLPqVQIV 112
Cdd:COG3897    48 FWAFLWPSGQALARYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAaDVTATDY--DPEALAALRLNAALNGVA-ITTR 123

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958657711 113 GLTWGhiskDTLSLPPQDIILGSDVFFEPE 142
Cdd:COG3897   124 LGDWR----DPPAAGGFDLILGGDVLYERD 149
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 35-141 2.59e-15

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 68.90  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958657711  35 GMYVWPCAVVLAQYL------WFHRRVLPGKAVLEIGAGVSLPGI-LAAKC-GAKVTLSDSPELPHCLDicwQSCQMNNL 106
Cdd:pfam10294  18 GGHVWDAAVVLSKYLemkifkELGANNLSGLNVLELGSGTGLVGIaVALLLpGASVTITDLEEALELLK---KNIELNAL 94

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958657711 107 -PQVQIVGLTWGH-ISKDTLSLPPQDIILGSD-VFFEP 141
Cdd:pfam10294  95 sSKVVVKVLDWGEnLPPDLFDGHPVDLILAADcVYNED 132
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
53-81 8.68e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 35.40  E-value: 8.68e-03
                          10        20
                  ....*....|....*....|....*....
gi 1958657711  53 RRVLPGKAVLEIGAGVSLPGILAAKCGAK 81
Cdd:COG4076    31 RVVKPGDVVLDIGTGSGLLSMLAARAGAK 59
PRK14968 PRK14968
putative methyltransferase; Provisional
 45-106 9.81e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 34.87  E-value: 9.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958657711  45 LAQYLwfhrRVLPGKAVLEIGAGVSLPGILAAKCGAKVTLSDSPelPHCLDICWQSCQMNNL 106
Cdd:PRK14968   15 LAENA----VDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDIN--PYAVECAKCNAKLNNI 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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